Riboproteome remodeling during quiescence exit in Saccharomyces cerevisiae

Autor: Clara A. Solari, María Clara Ortolá Martínez, Juan M. Fernandez, Christian Bates, Gerardo Cueto, María Pía Valacco, Fabián Morales-Polanco, Silvia Moreno, Silvia Rossi, Mark P. Ashe, Paula Portela

Publikováno v: iScience, Vol 27, Iss 1, Pp 108727- (2024)

Summary: The quiescent state is the prevalent mode of cellular life in most cells. Saccharomyces cerevisiae is a useful model for studying the molecular basis of the cell cycle, quiescence, and aging. Previous studies indicate that heterogeneous ribo

Externí odkaz: https://doaj.org/article/9edad135970d423c9fcda03143c924e8

HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells

Autor: Hannah Harrison, Henry J. Pegg, Jamie Thompson, Christian Bates, Paul Shore

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)

Abstract Background Hypoxia stimulates metastasis in cancer and is linked to poor patient prognosis. In tumours, oxygen levels vary and hypoxic regions exist within a generally well-oxygenated tumour. However, whilst the heterogeneous environment is

Externí odkaz: https://doaj.org/article/bebcf1d7c2c6452d9f55cd4745fe2e34

Integrated multi-omics reveals common properties underlying stress granule and P-body formation

Autor: Chris M. Grant, Mark P. Ashe, Michael G. Nelson, Martin D. Jennings, Christopher J. Kershaw, Christian Bates, Jennifer Lui, Simon J. Hubbard

Publikováno v: RNA Biology
article-version (VoR) Version of Record

Non-membrane-bound compartments such as P-bodies (PBs) and stress granules (SGs) play important roles in the regulation of gene expression following environmental stresses. We have systematically and quantitatively determined the protein and mRNA com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229686f5061365dd6411dba58bcf1287
http://europepmc.org/articles/PMC8782181

Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation

Autor: Claire Griffin, Jennifer Lui, Harriet E. Burt, Simon J. Hubbard, Mariavittoria Pizzinga, Mark P. Ashe, Clara A. Solari, Gabriela Forte, Paula Portela, Hannah L. Dixon, Christian Bates, Fabian Morales-Polanco, Joseph Casson, Kirsten E.L. Garner

Publikováno v: iScience, Vol 24, Iss 2, Pp 102069-(2021)
Morales Polanco, F, Bates, C, Lui, J, Casson, J, Solari, C, Pizzinga, M, Forte, G, Griffin, C, Garner, K, Burt, H, Dixon, H, Hubbard, S, Portela, P & Ashe, M 2021, ' Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation ', iScience, vol. 24, no. 2, 102069, pp. 1-18 . https://doi.org/10.1016/j.isci.2021.102069
iScience

Summary Glycolysis is a fundamental metabolic pathway for glucose catabolism across biology, and glycolytic enzymes are among the most abundant proteins in cells. Their expression at such levels provides a particular challenge. Here we demonstrate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdaecd8b9d96b12e045df1cdd607331
http://www.sciencedirect.com/science/article/pii/S2589004221000377

mRNA localization to translation factories: possible roles in mRNA inheritance and the co-ordinated expression of pathways or protein complex subunits

Autor: Christian Bates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03b5c50773a9489cf672916b6975f09a
https://doi.org/10.26226/morressier.5ebd45acffea6f735881af85