Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christian B. Gerhold"'
Autor:
Verena Hurst, Christian B. Gerhold, Cleo V. D. Tarashev, Kiran Challa, Andrew Seeber, Shota Yamazaki, Britta Knapp, Stephen B. Helliwell, Bernd Bodenmiller, Masahiko Harata, Kenji Shimada, Susan M. Gasser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Loss of cytosolic actin filaments upon TORC2 inhibition triggers chromosome fragmentation in yeast, which results from altered base excision repair of Zeocin-induced lesions. To find the link between TORC2 kinase and this yeast chromosome sh
Externí odkaz:
https://doaj.org/article/c6eea7d7981e47d3bf6b2e622889e3f4
Autor:
Kenji Shimada, Cleo V. D. Tarashev, Stephanie Bregenhorn, Christian B. Gerhold, Barbara van Loon, Gregory Roth, Verena Hurst, Josef Jiricny, Stephen B. Helliwell, Susan M. Gasser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Combinational therapies provoking cell death are of major interest in oncology. Combining TORC2 kinase inhibition with the radiomimetic drug Zeocin results in a rapid accumulation of double-strand breaks (DSB) in the budding yeast genome. Th
Externí odkaz:
https://doaj.org/article/ea98c450fa2d473d92ee49d1c6d4073b
Autor:
Larissa Brosi, Thomas K. Villiger, Frank I. Bantleon, Anna Melone, Marie-Eve Überschlag, Daniele Dolce, Cedric Giegelmann, Michael Gerspach, Lorin Dirscherl, Sherin Panikulam, Patrick Romann, Anna Weston, Eric Kübler, Christian-B. Gerhold
Publikováno v:
CHIMIA, Vol 75, Iss 5 (2021)
Serological testing for antibodies directed against SARS-CoV-2 in patients may serve as a diagnostic tool to verify a previous infection and as surrogate for an elicited humoral immune response, ideally conferring immunity after infection or vaccinat
Externí odkaz:
https://doaj.org/article/69e7fe4015df4f13ac4f5683a212ce03
Autor:
Davide Bertoldo, Verena Hurst, Kai Harada, Kenji Shimada, Christian Heinis, Jonas Wilbs, Raphael J. Gübeli, Yuichiro Takahashi, Ganesh Kumar Mothukuri, Masahiko Harata, Susan M. Gasser, Christian B. Gerhold
Publikováno v:
ACS Chemical Biology. 16:820-828
Actin is the most abundant protein in eukaryotic cells and is key to many cellular functions. The filamentous form of actin (F-actin) can be studied with help of natural products that specifically recognize it, as for example fluorophore-labeled prob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4145d4f31db081f1ab4373606e889e0
https://doi.org/10.1021/acschembio.0c00825
https://doi.org/10.1021/acschembio.0c00825
Autor:
Gregory Roth, Susan M. Gasser, Tarashev C, Josef Jiricny, Bregenhorn S, Christian B. Gerhold, Kenji Shimada, van Loon B, Christian Heinis, Hurst
SummaryInhibition of the TOR pathway (TORC2, or Ypk1/2), or the depolymerization of actin filaments results in catastrophic fragmentation of the yeast genome upon exposure to low doses of the radiomimetic drug Zeocin. We find that the accumulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da5d956614848185a7e3c3a5fe96add5
https://doi.org/10.1101/2020.11.15.383513
https://doi.org/10.1101/2020.11.15.383513
Autor:
Patrick Romann, Larissa Brosi, Marie-Eve Überschlag, Michael Gerspach, Christian B. Gerhold, Anna Melone, Frank I Bantleon, Anna Weston, Daniele Dolce, Sherin Panikulam, Cedric Giegelmann, Thomas K. Villiger, Eric Kübler, Lorin Dirscherl
Publikováno v:
CHIMIA. 75:446
Serological testing for antibodies directed against SARS-CoV-2 in patients may serve as a diagnostic tool to verify a previous infection and as surrogate for an elicited humoral immune response, ideally conferring immunity after infection or vaccinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab405463611ed0ca04115d9e7bdbd779
https://doi.org/10.2533/chimia.2021.446
https://doi.org/10.2533/chimia.2021.446
Autor:
Christian B. Gerhold, Susan M. Gasser
Publikováno v:
TRENDS IN CELL BIOLOGY
Virtually all DNA-dependent processes require selective and controlled access to the DNA sequence. Governing this access are sophisticated molecular machines, nucleosome remodelers, which regulate the composition and structure of chromatin, allowing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86c010ffcf9b94d143f083a2cca32e6
Autor:
Karl-Peter Hopfner, Christian B. Gerhold, Duane D. Winkler, Gregor Witte, Karolin Luger, Brigitte Kessler, Florian Seifert, K. Lakomek, Sebastian Fenn
Publikováno v:
Nucleic Acids Research
Nucleic acids research 40(21), 11036-11046 (2012). doi:10.1093/nar/gks842
Nucleic acids research 40(21), 11036-11046 (2012). doi:10.1093/nar/gks842
Nuclear actin-related proteins (Arps) are subunits of several chromatin remodelers, but their molecular functions within these complexes are unclear. We report the crystal structure of the INO80 complex subunit Arp8 in its ATP-bound form. Human Arp8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782a2bb306c7c9e41e1460b0db6e4907
https://doi.org/10.1093/nar/gks842
https://doi.org/10.1093/nar/gks842
Publikováno v:
BioArchitecture. 1:192-195
The function of nuclear actin is poorly understood. It is known to be a discrete component of several chromatin-modifying complexes. Nevertheless, filamentous forms of actin are important for various nuclear processes as well. Nuclear actin is often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738ecbb900ac6fe552ad84224ba99317
https://doi.org/10.4161/bioa.1.4.17643
https://doi.org/10.4161/bioa.1.4.17643
Autor:
Andrea Gilmozzi, Ruedi Aebersold, Franz Herzog, Roland Beckmann, Otto Berninghausen, Alessandro Tosi, Charlotte Ungewickell, Caroline Haas, Karl-Peter Hopfner, K. Lakomek, Christian B. Gerhold
Publikováno v:
Cell
SummaryINO80/SWR1 family chromatin remodelers are complexes composed of >15 subunits and molecular masses exceeding 1 MDa. Their important role in transcription and genome maintenance is exchanging the histone variants H2A and H2A.Z. We report the ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3868c12a3dcea07c491b2918a7814f69