Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christian B Macdonald"'
Autor:
Gabriella O Estevam, Edmond M Linossi, Christian B Macdonald, Carla A Espinoza, Jennifer M Michaud, Willow Coyote-Maestas, Eric A Collisson, Natalia Jura, James S Fraser
Publikováno v:
eLife, Vol 12 (2024)
MET is a receptor tyrosine kinase (RTK) responsible for initiating signaling pathways involved in development and wound repair. MET activation relies on ligand binding to the extracellular receptor, which prompts dimerization, intracellular phosphory
Externí odkaz:
https://doaj.org/article/b6001b942b874658867de1b8cb4e8907
Autor:
Christian B. Macdonald, David Nedrud, Patrick Rockefeller Grimes, Donovan Trinidad, James S. Fraser, Willow Coyote-Maestas
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Insertions and deletions (indels) enable evolution and cause disease. Due to technical challenges, indels are left out of most mutational scans, limiting our understanding of them in disease, biology, and evolution. We develop a low cost and
Externí odkaz:
https://doaj.org/article/11399c52db2f4426b21268f10cf7d139
Autor:
Ali A. Kermani, Christian B. Macdonald, Olive E. Burata, B. Ben Koff, Akiko Koide, Eric Denbaum, Shohei Koide, Randy B. Stockbridge
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Gdx-Clo is a bacterial transporter from the small multidrug resistance (SMR) family. Here, the authors use solid supported membrane electrophysiology to characterize Gdx-Clo functionally and report crystal structures of Gdx-Clo which confirm the dual
Externí odkaz:
https://doaj.org/article/d4785d992fee4f28884dcfc5aaeb641b
Publikováno v:
The Journal of biological chemistry, vol 298, iss 10
The small multidrug resistance (SMR) family is composed of widespread microbial membrane proteins that fulfill different transport functions. Four functional SMR subtypes have been identified, which variously transport the small, charged metabolite g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f154e2aee69fcde81bbc93c207a3ea6
https://escholarship.org/uc/item/332464j9
https://escholarship.org/uc/item/332464j9
Autor:
Christian B. Macdonald, David Nedrud, Patrick Rockefeller Grimes, Donovan Trinidad, James S. Fraser, Willow Coyote-Maestas
Insertions and deletions (indels) are a major source of genetic variation in evolution and the cause of nearly 30% of Mendelian disease. Despite their importance, indels are left out of nearly every systematic mutational scan to date due to technical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0d3c1051ed8660ce8b15749b799d8a4
https://doi.org/10.1101/2022.07.26.501589
https://doi.org/10.1101/2022.07.26.501589
Autor:
Christian B. Macdonald
Publikováno v:
Biophysical Journal. 122:519a
Autor:
B. Ben Koff, Christian B. Macdonald, Shohei Koide, Ali A. Kermani, Eric Denbaum, Akiko Koide, Randy B. Stockbridge, Olive E. Burata
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
By providing broad resistance to environmental biocides, transporters from the small multidrug resistance (SMR) family drive the spread of multidrug resistance cassettes among bacterial populations. A fundamental understanding of substrate selectivit
Publikováno v:
Biophysical Journal. 121:422a
Publikováno v:
Proceedings of the National Academy of Sciences. 115:3060-3065
The small multidrug resistance (SMR) family of membrane proteins is prominent because of its rare dual topology architecture, simplicity, and small size. Its best studied member, EmrE, is an important model system in several fields related to membran