Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Christian B Lessard"'
Autor:
Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, Yong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Todd E Golde
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-13 (2018)
Abstract Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how they confer this risk remains uncertain. We assessed binding of TREM2, AD‐associa
Externí odkaz:
https://doaj.org/article/7dfbdafcfc1640e899512df47529113f
Autor:
Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd, Joo In Jung, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 950-966 (2017)
Abstract γ‐Secretase inhibitors (GSIs) are being actively repurposed as cancer therapeutics based on the premise that inhibition of NOTCH1 signaling in select cancers is therapeutic. Using novel assays to probe effects of GSIs against a broader pa
Externí odkaz:
https://doaj.org/article/3fbd1320bd9d4856944b5a4a455c213b
Autor:
Christian B Lessard, Barbara A Cottrell, Hiroko Maruyama, Suraj Suresh, Todd E Golde, Edward H Koo
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144758 (2015)
The relative increase in Aβ42 peptides from familial Alzheimer disease (FAD) linked APP and PSEN mutations can be related to changes in both ε-cleavage site utilization and subsequent step-wise cleavage. Cleavage at the ε-site releases the amyloid
Externí odkaz:
https://doaj.org/article/cb28119b986b404a9c1fddfeba2d7131
Autor:
Christian B. Lessard, Edgardo Rodriguez, Thomas B. Ladd, Lisa M. Minter, Barbara A. Osborne, Lucio Miele, Todd E. Golde, Yong Ran
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-8 (2020)
Abstract Background γ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two catalytic subunits, presenilins 1 and 2 (PS1 and 2). In our previous report, we observed subt
Externí odkaz:
https://doaj.org/article/567da15a1da14d5dbc9b47ec7cc7ec8b
Autor:
Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E. Golde, Paul J. Whiting
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Background Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset Alzheimer’s disease (LOAD). Amongst these, a polymorphism in phospholipase C-gamma 2 (PLCG2) P52
Externí odkaz:
https://doaj.org/article/fec71a324e774372957bdf37f9b9949b
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3785bd08e6e80cf990e6c4d8721f56b
https://doi.org/10.1002/alz.069399
https://doi.org/10.1002/alz.069399
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::690685871367677f7a5bbc3c8eeb7ffc
https://doi.org/10.1002/alz.068002
https://doi.org/10.1002/alz.068002
Autor:
Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, Elsa Gonzalez De La Cruz, Shivani Shah, Quan Vo, Xue Wang, Zachary Quicksall, Daniel Ryu, Cory Funk, Nilüfer Ertekin-Taner, Stefan Prokop, Todd E. Golde, Paramita Chakrabarty
Publikováno v:
Alzheimer's Research & Therapy. 14
Background The S209F variant of Abelson Interactor Protein 3 (ABI3) increases risk for Alzheimer’s disease (AD), but little is known about its function in relation to AD pathogenesis. Methods Here, we use a mouse model that is deficient in Abi3 loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ab07b700d93afad3b4b21fa1990cd3
https://doi.org/10.1186/s13195-022-01044-1
https://doi.org/10.1186/s13195-022-01044-1
Autor:
Lisa M. Minter, Christian B. Lessard, Edgardo Rodriguez, Yong Ran, Thomas B. Ladd, Todd E. Golde, Barbara A. Osborne, Lucio Miele
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-8 (2020)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background γ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two catalytic subunits, presenilins 1 and 2 (PS1 and 2). In our previous report, we observed subtle differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4694f3231f13c43132ca64c32908c1e
http://link.springer.com/article/10.1186/s13195-020-00622-5
http://link.springer.com/article/10.1186/s13195-020-00622-5
Autor:
Cara L Croft, Marshall S Goodwin, Daniel H Ryu, Christian B Lessard, Giancarlo Tejeda, Marc Marrero, Ava Vause, Giavanna Paterno, Pedro E Cruz, Jada Lewis, Benoit Giasson, Todd E Golde
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7393a01e16babcc85b9105472dcc667
https://doi.org/10.1002/alz.056366
https://doi.org/10.1002/alz.056366