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of 17
pro vyhledávání: '"Christian Büchold"'
Autor:
Christian Büchold, Martin Hils, Uwe Gerlach, Johannes Weber, Christiane Pelzer, Andreas Heil, Daniel Aeschlimann, Ralf Pasternack
Publikováno v:
Cells, Vol 11, Iss 10, p 1667 (2022)
ZED1227 is a small molecule tissue transglutaminase (TG2) inhibitor. The compound selectively binds to the active state of TG2, forming a stable covalent bond with the cysteine in its catalytic center. The molecule was designed for the treatment of c
Externí odkaz:
https://doaj.org/article/b70e5471a4a248129807f527f0910cf4
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1002 (2021)
Hereditary factor XIII (FXIII) deficiency is a rare autosomal bleeding disorder which can cause life-threatening bleeding. Acquired deficiency can be immune-mediated or due to increased consumption or reduced synthesis. The most commonly used screeni
Externí odkaz:
https://doaj.org/article/ce18712aa0fb4a3890276545338e8b08
Autor:
Gerhard Klebe, Andreas Heine, Marisa Schmitt, Christian Büchold, Ralf Pasternack, Martin Stieler, Martin Hils
Publikováno v:
Chemmedchem
Blood coagulation factor XIII (FXIII, F13) is considered to be a promising target for anticoagulants with reduced bleeding risk because of its unique position in the coagulation cascade downstream of thrombin. However, until now, no potent drug addre
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1002, p 1002 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences
Volume 22
Issue 3
Hereditary factor XIII (FXIII) deficiency is a rare autosomal bleeding disorder which can cause life-threatening bleeding. Acquired deficiency can be immune-mediated or due to increased consumption or reduced synthesis. The most commonly used screeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecf3e81ef554ca79bb0c5204af4b18a
Autor:
Peter Florian, Götz Nowak, Uwe Gerlach, Ralf Pasternack, Christiane Pelzer, Martin Hils, Christian Büchold, Andreas Heil, Michael Sommer, Robert Jähnig
Publikováno v:
Journal of Thrombosis and Haemostasis
Background Factor XIII (FXIII) is the final enzyme of the coagulation cascade. While the other enzymatic coagulation factors are proteases, FXIII belongs to the transglutaminase family. FXIIIa covalently crosslinks the fibrin clot and represents a pr
Autor:
Jürgen Ohsam, Christian Büchold, Martin Hils, Ralf Pasternack, Keiichi Yokoyama, Andreas Heil, Yoshiyuki Kumazawa
Publikováno v:
Journal of Cereal Science. 70:47-56
Tissue transglutaminase (TG2) catalyzed glutamine deamidation within gluten peptides plays a major role in the pathogenesis of celiac disease. Recent studies reported gliadin deamidation by microbial transglutaminase (MTG) and hypothesize an impact o
Publikováno v:
Analytical Biochemistry. 600:113757
Plasma transglutaminase FXIII provides mechanical and biochemical stability to blood clots. Congenital or acquired deficiency may be associated with bleeding diathesis and requires therefore careful monitoring. The precise automated measurement of a
Autor:
Christian Büchold, Martin Hils, Johannes Weber, Andreas Heine, Peter Kolb, Gerhard Klebe, Martin Stieler, Ralf Pasternack
Publikováno v:
Angewandte Chemie. 125:12148-12153
Autor:
Johannes Weber, Martin Stieler, Ralf Pasternack, Christian Büchold, Martin Hils, Andreas Heine, Gerhard Klebe, Peter Kolb
Publikováno v:
Angewandte Chemie International Edition. 52:11930-11934
Publikováno v:
Thrombosis Research. 131:e214-e222
Introduction The A-subunit of blood coagulation factor XIII is a pro-transglutaminase, which cross-links α- and γ-fibrin-chains in its activated form. Selective inhibitors against FXIII-A may be desirable drugs to prevent the development of thrombo