Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christian A. Lobos"'
Autor:
Demetra S.M. Chatzileontiadou, Christian A. Lobos, Hayden Robson, Coral-Ann Almedia, Christopher Szeto, Alison Castley, Lloyd J. D’Orsogna, Stephanie Gras
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114555- (2024)
Summary: HIV controllers can control viral replication and remain healthy, but the mechanism behind this control is unknown. Despite human leukocyte antigen (HLA) diversity in the population, almost 50% of HIV controllers express the HLA-B∗57:01 mo
Externí odkaz:
https://doaj.org/article/132eb11625684b04becdf44331b5fdb1
Autor:
Andrea T. Nguyen, Christopher Szeto, Dhilshan Jayasinghe, Christian A. Lobos, Hanim Halim, Demetra S. M. Chatzileontiadou, Emma J. Grant, Stephanie Gras
Publikováno v:
Biophysica, Vol 1, Iss 2, Pp 194-203 (2021)
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has caused significant morbidity and mortality worldwide. With the remarkable advances in medical research, vaccines were developed to prime the human immune system and decrease disease sever
Externí odkaz:
https://doaj.org/article/cf3da1f68d4a451a9513421d801902a3
Autor:
Christopher Szeto, Demetra S.M. Chatzileontiadou, Andrea T. Nguyen, Hannah Sloane, Christian A. Lobos, Dhilshan Jayasinghe, Hanim Halim, Corey Smith, Alan Riboldi-Tunnicliffe, Emma J. Grant, Stephanie Gras
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102096- (2021)
Summary: CD8+ T cells are crucial for anti-viral immunity; however, understanding T cell responses requires the identification of epitopes presented by human leukocyte antigens (HLA). To date, few SARS-CoV-2-specific CD8+ T cell epitopes have been de
Externí odkaz:
https://doaj.org/article/f7bd7dd092ad4210939403cdcb929a33
Autor:
Christopher Szeto, Andrea T. Nguyen, Christian A. Lobos, Demetra S. M. Chatzileontiadou, Dhilshan Jayasinghe, Emma J. Grant, Alan Riboldi-Tunnicliffe, Corey Smith, Stephanie Gras
Publikováno v:
Cells, Vol 10, Iss 10, p 2646 (2021)
The data currently available on how the immune system recognises the SARS-CoV-2 virus is growing rapidly. While there are structures of some SARS-CoV-2 proteins in complex with antibodies, which helps us understand how the immune system is able to re
Externí odkaz:
https://doaj.org/article/65333e86f5364b86801ecd5353f45ef1
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 68 (2020)
T cells are a critical part of the adaptive immune system that are able to distinguish between healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T cells will contribute to the immune response and help clear infe
Externí odkaz:
https://doaj.org/article/0bcd09112e8a448bb80101c216d5df19
Autor:
Christopher Szeto, Joseph I. Bloom, Hannah Sloane, Christian A. Lobos, James Fodor, Dhilshan Jayasinghe, Demetra S. M. Chatzileontiadou, Emma J. Grant, Ashley M. Buckle, Stephanie Gras
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7081 (2020)
The interaction between T cell receptor (TCR) and peptide (p)-Human Leukocyte Antigen (HLA) complexes is the critical first step in determining T cell responses. X-ray crystallographic studies of pHLA in TCR-bound and free states provide a structural
Externí odkaz:
https://doaj.org/article/31cf5e6e498248b690293c52af96d339
Autor:
Christian A. Lobos, Jonathan Downing, Lloyd J. D'Orsogna, Demetra S.M. Chatzileontiadou, Stephanie Gras
Publikováno v:
Biochemical Society Transactions. 50:1329-1339
Understanding the basis of the immune determinants controlling disease outcome is critical to provide better care to patients and could be exploited for therapeutics and vaccine design. The discovery of the human immunodeficiency virus (HIV) virus as
Autor:
Demetra S.M. Chatzileontiadou, Christian A. Lobos, Hayden Robson, Coral-Ann Almedia, Christopher Szeto, Lloyd J. D’Orsogna, Stephanie Gras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d51dd5ca025f0c1d7f42fe54ea08644
https://doi.org/10.2139/ssrn.4439674
https://doi.org/10.2139/ssrn.4439674
Autor:
Christopher Szeto, Andrea T. Nguyen, Christian A. Lobos, Stephanie Gras, Emma J. Grant, Demetra S.M. Chatzileontiadou
Publikováno v:
Molecular Immunology. 120:101-112
Histocompatibility Leukocyte Antigens, or HLAs, are one of the most polymorphic molecules in humans. This high degree of polymorphism endows HLA molecules with the ability to present a vast array of peptides, an essential trait for responding to ever
Autor:
Andrea T. Nguyen, Christopher Szeto, Demetra S.M. Chatzileontiadou, Zhen Wei Marcus Tong, Michael J. Dewar-Oldis, Lucy Cooper, Lawton D. Murdolo, Keng Yih Chew, Katie E. Lineburg, Alan Riboldi-Tunicliffe, Rachel Williamson, Bradley J. Gardiner, Dhilshan Jayasinghe, Christian A. Lobos, You Min Ahn, Emma J. Grant, Corey Smith, James McMahon, Kim L. Good-Jacobson, Peter J. Barnard, Kirsty R. Short, Stephanie Gras
The >30 mutated residues in the Omicron spike protein have led to its rapid classification as a new SARS-CoV-2 variant of concern. As a result, Omicron may escape from the immune system, decreasing the protection provided by COVID-19 vaccines. Prelim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::800fd9b43783d0d69cbfa63b27e01b27
https://doi.org/10.1101/2022.01.12.473243
https://doi.org/10.1101/2022.01.12.473243