Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Christian A. Fernandez"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundAsparaginase (ASNase) is a crucial part of acute leukemia treatment, but immune responses to the agent can reduce its effectiveness and increase the risk of relapse. Currently, no reliable and validated biomarker predicts ASNase-induced hyp
Externí odkaz:
https://doaj.org/article/0bd814965dee4a029936fa2c86e71ce9
Autor:
Pearl Moharil, Zhuoya Wan, Apurva Pardeshi, Jiang Li, Haozhe Huang, Zhangyi Luo, Sanjay Rathod, Ziqian Zhang, Yuang Chen, Bei Zhang, Christian A. Fernandez, Jingjing Sun, Song Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1148-1162 (2022)
Combination of passive targeting with active targeting is a promising approach to improve the therapeutic efficacy of nanotherapy. However, most reported polymeric systems have sizes above 100 nm, which limits effective extravasation into tumors that
Externí odkaz:
https://doaj.org/article/02bac7177ba24ca8add70df186fd4e49
Autor:
Gundala Venkata Naveen Kumar, Keito Hoshitsuki, Sanjay Rathod, Manda J. Ramsey, Lauren Kokai, Erin E. Kershaw, Wen Xie, Christian A. Fernandez
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3779-3790 (2021)
PEGylated-l-asparaginase (PEG-ASNase) is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia (ALL). Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis, with obesity and older age co
Externí odkaz:
https://doaj.org/article/030f734db6814ff9a311d060430fa2e6
Autor:
Aboli Bhingarkar, Hima V. Vangapandu, Sanjay Rathod, Keito Hoshitsuki, Christian A. Fernandez
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Amino acid (AA) metabolism plays an important role in many cellular processes including energy production, immune function, and purine and pyrimidine synthesis. Cancer cells therefore require increased AA uptake and undergo metabolic reprogramming to
Externí odkaz:
https://doaj.org/article/ff8a01113fdd4ca48c72b357f0870b54
Publikováno v:
Haematologica, Vol 104, Iss 2 (2019)
Asparaginase is an important drug for the treatment of leukemias. However, anti-asparaginase antibodies often develop, which can decrease asparaginase drug levels and increase the risk of relapse. The aim of this study is to identify the immunoglobul
Externí odkaz:
https://doaj.org/article/6f4a541b90d544789ce1330bf4747c6e
Autor:
Priscila M S Castanha, Dylan J Tuttle, Georgios D Kitsios, Jana L Jacobs, Ulisses Braga-Neto, Matthew Duespohl, Sanjay Rathod, Michelle M Marti, Sarah Wheeler, Asma Naqvi, Brittany Staines, John Mellors, Alison Morris, Bryan J McVerry, Faraaz Shah, Caitlin Schaefer, Bernard J C Macatangay, Barbara Methe, Christian A Fernandez, Simon M Barratt-Boyes, Donald Burke, Ernesto T A Marques
Publikováno v:
The Journal of Infectious Diseases. 226:766-777
Background Excessive complement activation has been implicated in the pathogenesis of coronavirus disease 2019 (COVID-19), but the mechanisms leading to this response remain unclear. Methods We measured plasma levels of key complement markers, severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d189f3f02758fa92a3b1a6a2f3ed66
https://doi.org/10.1093/infdis/jiac091
https://doi.org/10.1093/infdis/jiac091
Autor:
Jorge Campos Parra, Guillermo Wells Moncada, Marcelo Doussoulin Guzmán, Christian Guajardo Fernandez, Rita Astudillo-Neira, Solange Vásquez Obando, Jorge Labrín Mendez
Publikováno v:
Ciencias agrarias: Estudios sistemáticos e investigación avanzada ISBN: 9786525808444
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa14590e7f8e6c2868f9526e46ef654d
https://doi.org/10.22533/at.ed.4442208128
https://doi.org/10.22533/at.ed.4442208128
Publikováno v:
2022 IEEE 14th International Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment, and Management (HNICEM).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89deacffa356b8561a14e3ba8f063301
https://doi.org/10.1109/hnicem57413.2022.10109418
https://doi.org/10.1109/hnicem57413.2022.10109418
Publikováno v:
2022 IEEE International Autumn Meeting on Power, Electronics and Computing (ROPEC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9291a499a709bb5279d71cb74e9730f
https://doi.org/10.1109/ropec55836.2022.10018639
https://doi.org/10.1109/ropec55836.2022.10018639
Publikováno v:
Blood Adv
The family of nuclear factor of activated T cells (NFAT) transcription factors plays a critical role in mediating immune responses. Our previous clinical pharmacogenetic studies suggested that NFATC2 is associated with the risk of hypersensitivity re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edaa5878e556f09a3a6f144c9123322
https://doi.org/10.1182/bloodadvances.2020002478
https://doi.org/10.1182/bloodadvances.2020002478