Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christian A. Cumbaa"'
Autor:
Sasan Zandi, Kerstin B. Kaufmann, Mike J. Tsay, Laura García-Prat, Stanley W.K. Ng, Chiara Pastrello, Mark D. Minden, John E. Dick, Gabriela Krivdova, Jean C.Y. Wang, Elvin Wagenblast, Eric R. Lechman, Stephanie Z. Xie, Qiang Liu, Peter van Galen, Igor Jurisica, Amanda Mitchell, Erno Wienholds, Shin-ichiro Takayanagi, Christian A. Cumbaa
Publikováno v:
Blood. 133:2198-2211
There is a growing body of evidence that the molecular properties of leukemia stem cells (LSCs) are associated with clinical outcomes in acute myeloid leukemia (AML), and LSCs have been linked to therapy failure and relapse. Thus, a better understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::261572ea9298c8308e82a07da91900cb
https://doi.org/10.1182/blood-2018-10-881441
https://doi.org/10.1182/blood-2018-10-881441
Autor:
Vinod Chandran, Mark Abovsky, Proton Rahman, Richard Lu, Sara Rahmati, Igor Jurisica, Christian A. Cumbaa, Max Kotlyar, Chiara Pastrello
Publikováno v:
Nucleic Acids Research
PathDIP was introduced to increase proteome coverage of literature-curated human pathway databases. PathDIP 4 now integrates 24 major databases. To further reduce the number of proteins with no curated pathway annotation, pathDIP integrates pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb52ab57d52eba6c4837c48bfaea1b9
https://doi.org/10.1093/nar/gkz989
https://doi.org/10.1093/nar/gkz989
Autor:
Kerstin B, Kaufmann, Laura, Garcia-Prat, Qiang, Liu, Stanley W K, Ng, Shin-Ichiro, Takayanagi, Amanda, Mitchell, Erno, Wienholds, Peter, van Galen, Christian A, Cumbaa, Mike J, Tsay, Chiara, Pastrello, Elvin, Wagenblast, Gabriela, Krivdova, Mark D, Minden, Eric R, Lechman, Sasan, Zandi, Igor, Jurisica, Jean C Y, Wang, Stephanie Z, Xie, John E, Dick
Publikováno v:
Blood. 133(20)
There is a growing body of evidence that the molecular properties of leukemia stem cells (LSCs) are associated with clinical outcomes in acute myeloid leukemia (AML), and LSCs have been linked to therapy failure and relapse. Thus, a better understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::597cc163446a983f2e59e504d5904f2f
https://pubmed.ncbi.nlm.nih.gov/30796022
https://pubmed.ncbi.nlm.nih.gov/30796022
Autor:
Andrea Jurisicova, Christian A. Cumbaa, Han Li, Zhiyong Ding, Julia Petschnigg, Igor Jurisica, Gordon B. Mills, Fiona Broackes-Carter, Taline Naranian, Chiara Pastrello, Fatemeh Vafaee, Yun Niu, Igor Stagljar, Roberta Maestro, Alessandra Lo Sardo, Flavia Pivetta, Max Kotlyar
Publikováno v:
Nature Methods. 12:79-84
Protein-protein interactions (PPIs) are useful for understanding signaling cascades, predicting protein function, associating proteins with disease and fathoming drug mechanism of action. Currently, only ∼ 10% of human PPIs may be known, and about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bea00945147ae00bcedea56b1c5455
https://doi.org/10.1038/nmeth.3178
https://doi.org/10.1038/nmeth.3178
Autor:
Igor Jurisica, Christian A. Cumbaa
Publikováno v:
Journal of Structural and Functional Genomics
We have developed an image-analysis and classification system for automatically scoring images from high-throughput protein crystallization trials. Image analysis for this system is performed by the Help Conquer Cancer (HCC) project on the World Comm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87abae59bea072a188e92ca5aabc21f5
https://doi.org/10.1007/s10969-009-9076-9
https://doi.org/10.1007/s10969-009-9076-9
Autor:
Igor Jurisica, Angela M. Lauricella, Michael G. Malkowski, George T. DeTitta, Christian A. Cumbaa, Stacey Gulde, Stephen A. Potter, Geoff Franks, Robert J. Collins, Edward H. Snell, Joseph R. Luft
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
As part of a training set for automated image analysis, crystallization screening experiments for 269 different macromolecules were visually analyzed and a set of crystal images extracted. Outcomes and trends are analyzed.
In the automated image
In the automated image
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc040dd0656b6abf15544af45a5a9475
https://doi.org/10.1107/s0907444908028059
https://doi.org/10.1107/s0907444908028059
Autor:
Edward H. Snell, Joseph R. Luft, Angela M. Lauricella, Stacey Gulde, Robert J. Collins, Max H. Thayer, Stephen A. Potter, Michael G. Malkowski, Christina K. Veatch, George T. DeTitta, Geoff Franks, Meriem I. Said, Igor Jurisica, Christian A. Cumbaa, Mary Koszelak-Rosenblum, Jennifer L. Smith
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 64:1123-1130
Structural crystallography aims to provide a three-dimensional representation of macromolecules. Many parts of the multistep process to produce the three-dimensional structural model have been automated, especially through various structural genomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8197fa9c70722ca6624ed46bcc6e7ac0
https://doi.org/10.1107/s0907444908028047
https://doi.org/10.1107/s0907444908028047
Autor:
Dennis A. Wigle, Marlena Maziarz, Ming-Sound Tsao, Mujahid Sultan, Igor Jurisica, Christian A. Cumbaa, Janice I. Glasgow
Publikováno v:
ISMB
Motivation: With the increasing number of gene expression databases, the need for more powerful analysis and visualization tools is growing. Many techniques have successfully been applied to unravel latent similarities among genes and/or experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbc61f2f25a4de2acdae52b08652264
https://doi.org/10.1093/bioinformatics/18.suppl_1.s111
https://doi.org/10.1093/bioinformatics/18.suppl_1.s111
Autor:
Fletcher Lu, Coralee Allaby, Kinson Ho, Alex Qian, Bowen Hui, Saheem Siddiqi, Mark Fitzgerald, Robin Cohen, Christian A. Cumbaa, Celine Latulipe, Nancy Moussa, David M. Pooley
Publikováno v:
User Modeling and User-Adapted Interaction. 8:171-214
This paper presents some alternate theories for explaining the term ’initiative‘, as it is used in the design of mixed-initiative AI systems. Although there is now active research in the area of mixed initiative interactive systems, there appears
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf4bc3c260cccd12bbf058cf01d90ce9
https://doi.org/10.1023/a:1008398023083
https://doi.org/10.1023/a:1008398023083
Autor:
Robert J. Collins, Igor Jurisica, Angela M. Lauricella, Joseph R. Luft, Christian A. Cumbaa, George T. DeTitta, Christina K. Veatch, Nancy A. Fehrman
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 59(Pt 9)
A technique for automatically evaluating microbatch (400 nl) protein-crystallization trials is described. This method addresses analysis problems introduced at the sub-microlitre scale, including non-uniform lighting and irregular droplet boundaries.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c599ac15154625cc9b20ea59b43fa86
https://pubmed.ncbi.nlm.nih.gov/12925793
https://pubmed.ncbi.nlm.nih.gov/12925793