Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Christian A. Combs"'
Autor:
Azaan Rehman, Alexander Zhovmer, Ryo Sato, Yoh-suke Mukouyama, Jiji Chen, Alberto Rissone, Rosa Puertollano, Jiamin Liu, Harshad D. Vishwasrao, Hari Shroff, Christian A. Combs, Hui Xue
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Deep neural networks can improve the quality of fluorescence microscopy images. Previous methods, based on Convolutional Neural Networks (CNNs), require time-consuming training of individual models for each experiment, impairing their applic
Externí odkaz:
https://doaj.org/article/0f066acd3b8344f79e170a1e9cae9366
Autor:
Diego Lucero, Ozan Dikilitas, Michael M. Mendelson, Zahra Aligabi, Promotto Islam, Edward B. Neufeld, Aruna T. Bansal, Lita A. Freeman, Boris Vaisman, Jingrong Tang, Christian A. Combs, Yuesheng Li, Szilard Voros, Iftikhar J. Kullo, Alan T. Remaley
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 1, Pp 100160- (2022)
A significant proportion of patients with elevated LDL and a clinical presentation of familial hypercholesterolemia do not carry known genetic mutations associated with hypercholesterolemia, such as defects in the LDL receptor. To identify new genes
Externí odkaz:
https://doaj.org/article/36e2a63f6e5b47bb9ee2ec4ae8fc5638
Autor:
Anna Kosmach, Barbara Roman, Junhui Sun, Armel Femnou, Fan Zhang, Chengyu Liu, Christian A. Combs, Robert S. Balaban, Elizabeth Murphy
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109846- (2021)
Summary: Optical methods for measuring intracellular ions including Ca2+ revolutionized our understanding of signal transduction. However, these methods are not extensively applied to intact organs due to issues including inner filter effects, motion
Externí odkaz:
https://doaj.org/article/a1ab2a388f32422783bb43c2b583361f
Autor:
Brian Glancy, Lisa M. Hartnell, Christian A. Combs, Armel Femnou, Junhui Sun, Elizabeth Murphy, Sriram Subramaniam, Robert S. Balaban
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 487-496 (2017)
Summary: Mitochondrial network connectivity enables rapid communication and distribution of potential energy throughout the cell. However, this connectivity puts the energy conversion system at risk, because damaged elements could jeopardize the enti
Externí odkaz:
https://doaj.org/article/d2ae6242d73c44a7a9ae2537520d6994
Autor:
Edward B. Neufeld, Katherine O'Brien, Avram D. Walts, John A. Stonik, Daniela Malide, Christian A. Combs, Alan T. Remaley
Publikováno v:
Biology, Vol 3, Iss 4, Pp 866-891 (2014)
We have previously shown that GFP-tagged human ABCG1 on the plasma membrane (PM) and in late endosomes (LE) mobilizes sterol on both sides of the membrane lipid bilayer, thereby increasing cellular cholesterol efflux to lipid surfaces. In the present
Externí odkaz:
https://doaj.org/article/5ccc75f0e42d42538bf88cedf508b95b
Autor:
Edward B. Neufeld, Katherine O'Brien, Avram D. Walts, John A. Stonik, Steven J. Demosky, Daniela Malide, Christian A. Combs, Alan T. Remaley
Publikováno v:
Biology, Vol 3, Iss 4, Pp 781-800 (2014)
We have developed a suitable heterologous cell expression system to study the localization, trafficking, and site(s) of function of the human ABCG1 transporter. Increased plasma membrane (PM) and late endosomal (LE) cholesterol generated by ABCG1 was
Externí odkaz:
https://doaj.org/article/a0d5da5cd5484533aadedc573e9665c8
Autor:
Brian Glancy, Lisa M. Hartnell, Christian A. Combs, Armel Femnou, Junhui Sun, Elizabeth Murphy, Sriram Subramaniam, Robert S. Balaban
Publikováno v:
Cell Reports, Vol 23, Iss 9, p 2832 (2018)
Externí odkaz:
https://doaj.org/article/a869924517de41d2ba18c6a9e75363c4
Autor:
Yicong Wu, Ryan Christensen, Arpita Upadhyaya, Jiamin Liu, Yilun Sun, Akshay Patel, Titas Sengupta, Yves Pommier, Hari Shroff, Ivan Rey-Suarez, Jonathan S. Daniels, Christian A. Combs, Daniel A. Colón-Ramos, Lingyu Bao, Jiji Chen, Melissa Glidewell, Junhui Sun, Xufeng Wu, Robert S. Fischer, Xiaofei Han, Corey Smith, Leighton H. Duncan, Yun-Bo Shi, Sougata Roy, Yijun Su, Elizabeth Murphy, Patrick J. La Riviere
Publikováno v:
Nature. 600:279-284
Confocal microscopy1 remains a major workhorse in biomedical optical microscopy owing to its reliability and flexibility in imaging various samples, but suffers from substantial point spread function anisotropy, diffraction-limited resolution, depth-
Autor:
Philip Bleicher, Neil Billington, Ryan Hart, Christian A. Combs, Shureed Qazi, Indra Chandrasekar, Jay R. Knutson, James R. Sellers
Publikováno v:
Biophysical Journal. 122:166a
Autor:
Laxminath Tumburu, Mehdi Pirooznia, Arun S. Shet, Luis E.F. Almeida, James S. Nichols, Jun Zhu, Eric Lindberg, Maliha Maryam Ahmad, Christopher K. E. Bleck, Ilker Tunc, Ishwarya Sivakumar, Christian A. Combs, Emilia Alina Barbu, Fayaz Seifuddin, Lauren H. W. Wilkins, Swee Lay Thein, Shohini Ghosh-Choudhary, Shutong Yang, Simon Yang, Pradeep K. Dagur, Zenaide M.N. Quezado, Jay H. Chung
Publikováno v:
Blood
The pathophysiology of sickle cell disease (SCD) is driven by chronic inflammation fueled by damage associated molecular patterns (DAMPs). We show that elevated cell-free DNA (cfDNA) in patients with SCD is not just a prognostic biomarker, it also co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd088c5875ba43424f5c0c86979f0f0
https://europepmc.org/articles/PMC8176765/
https://europepmc.org/articles/PMC8176765/