Zobrazeno 1 - 10
of 1 488
pro vyhledávání: '"Christian Trautwein"'
Autor:
Sylvia M. Brakenhoff, Thymen Theijse, Peter van Wijngaarden, Christian Trautwein, Jonathan F. Brozat, Frank Tacke, Pieter Honkoop, Thomas Vanwolleghem, Dirk Posthouwer, Stefan Zeuzem, Ulrike Mihm, Heiner Wedemeyer, Thomas Berg, Solko W. Schalm, Robert J. de Knegt
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background and Aims Systematic reviews and medical guidelines are widely used in clinical practice. However, these are often not up-to-date and focussed on the average patient. We therefore aimed to evaluate a guideline add-on, TherapySelect
Externí odkaz:
https://doaj.org/article/c576f08441324371baa5a462203e8cd0
Autor:
Johanna Reißing, Marie Berres, Pavel Strnad, Alexander Wree, Maria Eugenia Inzaugarat, Christian Trautwein, Tony Bruns, Henning Wolfgang Zimmermann
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 4, Pp 517-538 (2024)
Background & Aims: Type 2 immune responses contribute to liver fibrosis in parasite infections, but their role in other liver diseases is less well understood. Here, we aimed at unravelling mechanisms involved in T helper 2 (Th2) T-cell polarization,
Externí odkaz:
https://doaj.org/article/3ffa487cb3d548f9bcf2f9e10327e30b
Autor:
Leonida Hehl, Kate T. Creasy, Cecilia Vitali, Eleonora Scorletti, Katharina S. Seeling, Mara S. Vell, Miriam D. Rendel, Donna Conlon, Regeneron Genetics Center, Marijana Vujkovic, Inuk Zandvakili, Christian Trautwein, Kai M. Schneider, Daniel J. Rader, Carolin V. Schneider
Publikováno v:
Hepatology Communications, Vol 8, Iss 5 (2024)
Background:. Common variants of the max-like protein X (MLX)-interacting protein-like (MLXIPL) gene, encoding the transcription factor carbohydrate-responsive element-binding protein, have been shown to be associated with plasma triglyceride levels.
Externí odkaz:
https://doaj.org/article/183435d2206a42fdbf55f5d2b4325b1c
Autor:
Sven H. Loosen, Fabian Benz, Raphael Mohr, Philipp A. Reuken, Theresa H. Wirtz, Lioba Junker, Christian Jansen, Carsten Meyer, Michael Praktiknjo, Alexander Wree, Johanna Reißing, Münevver Demir, Wenyi Gu, Mihael Vucur, Robert Schierwagen, Andreas Stallmach, Anselm Kunstein, Johannes Bode, Christian Trautwein, Frank Tacke, Tom Luedde, Tony Bruns, Jonel Trebicka, Christoph Roderburg
Publikováno v:
JHEP Reports, Vol 6, Iss 5, Pp 101054- (2024)
Background & Aims: Transjugular intrahepatic portosystemic shunt (TIPS) is the most effective therapy for complications of portal hypertension. However, clinical outcomes following TIPS placement vary widely between patients and identifying ideal can
Externí odkaz:
https://doaj.org/article/1c0266d113654c7496f7e96b4601da0f
Autor:
Julia Otto, Anna Verwaayen, Christian Penners, Jana Hundertmark, Cheng Lin, Carina Kallen, Daniela Paffen, Tobias Otto, Hilmar Berger, Frank Tacke, Ralf Weiskirchen, Yulia A. Nevzorova, Matthias Bartneck, Christian Trautwein, Roland Sonntag, Christian Liedtke
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-15 (2023)
Abstract Hepatocellular carcinoma (HCC) is one of the most severe malignancies with increasing incidence and limited treatment options. Typically, HCC develops during a multistep process involving chronic liver inflammation and liver fibrosis. The la
Externí odkaz:
https://doaj.org/article/45c433be5aaf43cdb0361d45f0a768b8
Autor:
Isabella Lurje, Nadine Therese Gaisa, Edgar Dahl, Ruth Knüchel, Pavel Strnad, Christian Trautwein, Frank Tacke, Ulf Peter Neumann, Zoltan Czigany, Georg Lurje
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Intrahepatic cholangiocarcinoma (iCCA) is a rare, understudied primary hepatic malignancy with dismal outcomes. Aiming to identify prognostically relevant single-nucleotide polymorphisms, we analyzed 11 genetic variants with a role in tumor-
Externí odkaz:
https://doaj.org/article/3e22b6cfed4d4731919f9e4b2cc6b830
Autor:
Julius W. Jaeger, Annette Brandt, Wenfang Gui, Timur Yergaliyev, Angélica Hernández-Arriaga, Mukil Marutha Muthu, Karolina Edlund, Ahmed Elashy, Antonio Molinaro, Diana Möckel, Jan Sarges, Emina Halibasic, Michael Trauner, Florian Kahles, Ulrike Rolle-Kampczyk, Jan Hengstler, Carolin Victoria Schneider, Twan Lammers, Hanns-Ulrich Marschall, Martin von Bergen, Amélia Camarinha-Silva, Ina Bergheim, Christian Trautwein, Kai Markus Schneider
Publikováno v:
JHEP Reports, Vol 6, Iss 3, Pp 100987- (2024)
Background & Aims: Changes in gut microbiota in metabolic dysfunction-associated steatotic liver disease (MASLD) are important drivers of disease progression towards fibrosis. Therefore, reversing microbial alterations could ameliorate MASLD progress
Externí odkaz:
https://doaj.org/article/10a4d1cb0ace4ea8896d22c090b00411
Autor:
Wenfang Gui, Mikal Jacob Hole, Antonio Molinaro, Karolina Edlund, Kristin K. Jørgensen, Huan Su, Brigitte Begher-Tibbe, Nikolaus Gaßler, Carolin V. Schneider, Uthayakumar Muthukumarasamy, Antje Mohs, Lijun Liao, Julius Jaeger, Christian J. Mertens, Ina Bergheim, Till Strowig, Jan G. Hengstler, Johannes R. Hov, Hanns-Ulrich Marschall, Christian Trautwein, Kai Markus Schneider
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of the biliary tree. The majority of PSC patients suffer from concomitant inflammatory bowel disease (
Externí odkaz:
https://doaj.org/article/822db6e3defc4196a740ad1cdce3eff7
Autor:
Linde Kehmann, Marie-Luise Berres, Maria Gonzalez-Carmona, Dominik P. Modest, Raphael Mohr, Alexander Wree, Marino Venerito, Christian Strassburg, Verena Keitel, Christian Trautwein, Tom Luedde, Christoph Roderburg
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background The prognosis of patients with advanced biliary tract cancer (BTC) who have progressed on gemcitabine plus cisplatin is dismal. Trifluridine/tipiracil (FTD/TPI) and irinotecan have proven efficacy in different gastrointestinal mal
Externí odkaz:
https://doaj.org/article/adcfd14080b94e43bba7e5c89b37d3ba
Autor:
Mohamed Ramadan Mohamed, Johannes Haybaeck, Hanghang Wu, Huan Su, Matthias Bartneck, Cheng Lin, Mark V. Boekschoten, Peter Boor, Benjamin Goeppert, Christian Rupp, Pavel Strnad, Roger J. Davis, Francisco Javier Cubero, Christian Trautwein
Publikováno v:
JHEP Reports, Vol 5, Iss 11, Pp 100854- (2023)
Background & Aims: Cholestatic liver injury is associated with c-Jun N-terminal kinases (JNK) activation in distinct cell types. Its hepatocyte-specific function during cholestasis, however, has not yet been established. Therefore, in our present stu
Externí odkaz:
https://doaj.org/article/467df02364504bde82f2dfe209af1a10