Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Christian Thirion"'
Autor:
Jana Fuchs, Julian Hübner, Anna Schmidt, Pascal Irrgang, Clara Maier, Ana Vieira Antão, Friederike Oltmanns, Christian Thirion, Dennis Lapuente, Matthias Tenbusch
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Respiratory syncytial virus (RSV) is the leading cause of severe lower respiratory tract infections in infants and toddlers. Since natural infections do not induce persistent immunity, there is the need of vaccines providing long-term protec
Externí odkaz:
https://doaj.org/article/f6ca5b83ec59445c983e3d1cc0012d15
Autor:
Jannik T. Wagner, Sandra M. Müller-Schmucker, Wenjun Wang, Philipp Arnold, Nadja Uhlig, Leila Issmail, Valentina Eberlein, Dominik Damm, Kaveh Roshanbinfar, Armin Ensser, Friederike Oltmanns, Antonia Sophia Peter, Vladimir Temchura, Silke Schrödel, Felix B. Engel, Christian Thirion, Thomas Grunwald, Manfred Wuhrer, Dirk Grimm, Klaus Überla
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Long-acting passive immunization strategies are needed to protect immunosuppressed vulnerable groups from infectious diseases. To further explore this concept for COVID-19, we constructed Adeno-associated viral (AAV) vectors encoding the hum
Externí odkaz:
https://doaj.org/article/fb0eb88696d04de18d534ac0c445bf7a
Autor:
Lena Prantl, Philipp Heider, Lisa Bergmeister, Katharina Calana, Jan-Paul Bohn, Dominik Wolf, Zoltan Banki, Andreas Bosch, Maximilian Plach, Georg Huber, Silke Schrödel, Christian Thirion, Heribert Stoiber
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Antibody-mediated complement-dependent cytotoxicity (CDC) on malignant cells is regulated by several complement control proteins, including the inhibitory complement factor H (fH). fH consists of 20 short consensus repeat elements (SCRs) with specifi
Externí odkaz:
https://doaj.org/article/fd7bcb08e40f4d34bd49d48974f1b01c
Autor:
Patrick Neckermann, Madlen Mohr, Martina Billmeier, Alexander Karlas, Ditte R. Boilesen, Christian Thirion, Peter J. Holst, Ingo Jordan, Volker Sandig, Benedikt Asbach, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Modified vaccinia virus Ankara is a versatile vaccine vector, well suited for transgene delivery, with an excellent safety profile. However, certain transgenes render recombinant MVA (rMVA) genetically unstable, leading to the accumulation of mutated
Externí odkaz:
https://doaj.org/article/04652d8cafeb4982bcb8ca46679fd314
Autor:
Per thor Straten, Ralf Wagner, Peter Holst, Louise Turner, Amaia V Bermejo, Isabella Skandorff, Lasse Neukirch, Jasmin Gille, Frederik O Bagger, Karen N Nielsen, Joana Daradoumis, Charlie R Ince, Lara Duvnjak, Mikkel D Müller, Silke Schrödel, Kaare Grunddal, Kristoffer Staahl Rohrberg, Christian Thirion, Anne-Marie Andersson, Emeline Ragonnaud
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/6005f92247f24444a2644dd3773cfafa
Autor:
Anna Schmidt, Basudev Paudyal, Sonia Villanueva-Hernández, Adam Mcnee, Eleni Vatzia, Brigid Veronica Carr, Selma Schmidt, Amy Mccarron, Veronica Martini, Silke Schroedel, Christian Thirion, Ryan Waters, Francisco J. Salguero, Wilhelm Gerner, Matthias Tenbusch, Elma Tchilian
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T cell responses directed against highly conserved viral proteins contribute to the clearance of the influenza virus and confer broadly cross-reactive and protective immune responses against a range of influenza viruses in mice and ferrets. We examin
Externí odkaz:
https://doaj.org/article/7a124e0b2d554bd1b327bae9c7f98cfe
Autor:
Dennis Lapuente, Jana Fuchs, Jonas Willar, Ana Vieira Antão, Valentina Eberlein, Nadja Uhlig, Leila Issmail, Anna Schmidt, Friederike Oltmanns, Antonia Sophia Peter, Sandra Mueller-Schmucker, Pascal Irrgang, Kirsten Fraedrich, Andrea Cara, Markus Hoffmann, Stefan Pöhlmann, Armin Ensser, Cordula Pertl, Torsten Willert, Christian Thirion, Thomas Grunwald, Klaus Überla, Matthias Tenbusch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
While current COVID-19 vaccines provide certain protection, more effective vaccination strategies are still desirable. Here the authors show, using mouse vaccination models, that priming with a systemic mRNA and boosting with an intranasal adenoviral
Externí odkaz:
https://doaj.org/article/2d658f5bfe1141c4acf2fa4bf72300b6
Autor:
Isabella Skandorff, Jasmin Gille, Emeline Ragonnaud, Anne-Marie Andersson, Silke Schrödel, Christian Thirion, Ralf Wagner, Peter Johannes Holst
Publikováno v:
Viruses, Vol 15, Iss 8, p 1686 (2023)
Human endogenous retrovirus type W (HERV-W) is expressed in various cancers. We previously developed an adenovirus-vectored cancer vaccine targeting HERV-W by encoding an assembled HERV-W group-specific antigen sequence and the HERV-W envelope sequen
Externí odkaz:
https://doaj.org/article/6ff44ac6325b4c3fbf68e8651fba33f8
Autor:
Joana Daradoumis, Emeline Ragonnaud, Isabella Skandorff, Karen Nørgaard Nielsen, Amaia Vergara Bermejo, Anne-Marie Andersson, Silke Schroedel, Christian Thirion, Lasse Neukirch, Peter Johannes Holst
Publikováno v:
Viruses, Vol 15, Iss 4, p 926 (2023)
Endogenous retroviruses (ERVs) account for 8% of our genome, and, although they are usually silent in healthy tissues, they become reactivated and expressed in pathological conditions such as cancer. Several studies support a functional role of ERVs
Externí odkaz:
https://doaj.org/article/865093eda5b24acd842bb11e17ec108b
Autor:
Patrick Neckermann, Ditte Rahbaek Boilesen, Torsten Willert, Cordula Pertl, Silke Schrödel, Christian Thirion, Benedikt Asbach, Peter Johannes Holst, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Persistent human papillomavirus (HPV) infections are causative for cervical neoplasia and carcinomas. Despite the availability of prophylactic vaccines, morbidity and mortality induced by HPV are still too high. Thus, an efficient therapy, such as a
Externí odkaz:
https://doaj.org/article/cb37000a98b34924874487cd719fc1c7