Zobrazeno 1 - 10
of 1 295
pro vyhledávání: '"Christian Klein"'
Autor:
Macarena Román Alonso, Ariadna Grinyó-Escuer, Santiago Duro-Sánchez, Irene Rius-Ruiz, Marta Bort-Brusca, Marta Escorihuela, Susana Maqueda-Marcos, Sandra Pérez-Ramos, Judit Gago, Vanesa Nogales, Martín Espinosa-Bravo, Vicente Peg, Santiago Escrivá-de-Romaní, Laia Foradada, Laura Soucek, Irene Braña, Vladimir Galvao, Silvia Martín-Lluesma, Ekkehard Moessner, Christian Klein, Elena Garralda, Cristina Saura, Joaquín Arribas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The redirection of T lymphocytes against tumor-associated or tumor-specific antigens, using bispecific antibodies or chimeric antigen receptors (CAR), has shown therapeutic success against certain hematological malignancies. However, this st
Externí odkaz:
https://doaj.org/article/b9b02825ad104b89906a58c00d16e417
Autor:
Marlena Surowka, Christian Klein
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Bispecific antibodies (bsAbs) are a class of antibodies that can mediate novel mechanisms of action compared to monospecific monoclonal antibodies (mAbs). Since the discovery of mAbs and their adoption as therapeutic agents in the 1980s and 1990s, th
Externí odkaz:
https://doaj.org/article/f56b39943c694d6697f67b9d846bd8d7
Publikováno v:
Journal of High Energy Physics, Vol 2024, Iss 5, Pp 1-25 (2024)
Abstract The production of virtual photons is a very sensitive probe of the properties of the quark-gluon plasma. As they are experimentally detected by lepton pairs, they suffer from a large background arising from hadron decays. Light-flavour hadro
Externí odkaz:
https://doaj.org/article/d43ee177637b4f658d6c19be441d527d
Autor:
Estelle Marrer-Berger, Annalisa Nicastri, Angelique Augustin, Vesna Kramar, Hanqing Liao, Lydia Jasmin Hanisch, Alejandro Carpy, Tina Weinzierl, Evelyne Durr, Nathalie Schaub, Ramona Nudischer, Daniela Ortiz-Franyuti, Ekaterina Breous-Nystrom, Janick Stucki, Nina Hobi, Giulia Raggi, Lauriane Cabon, Emmanuelle Lezan, Pablo Umaña, Isaac Woodhouse, Alexander Bujotzek, Christian Klein, Nicola Ternette
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Selective binding of TCR-like antibodies that target a single tumour-specific peptide antigen presented by human leukocyte antigens (HLA) is the absolute prerequisite for their therapeutic suitability and patient safety. To date, selectivity
Externí odkaz:
https://doaj.org/article/1e7a4a6f3006436c814053de1558d191
Autor:
Marius Werner, Julian Brinkhofer, Leon Hammermüller, Thomas Heim, Truc Lam Pham, Jonas Huber, Christian Klein, Franziska Thomas
Publikováno v:
Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract Organoboron compounds have a wide range of applications in numerous research fields, and methods to incorporate them in biomolecules are much sought after. Here, on‐resin chemical syntheses of aliphatic and vinylogous peptide boronic acids
Externí odkaz:
https://doaj.org/article/d5e09794582443c7866ade50f4552701
Autor:
Johannes Reusch, Linda Elise Franken, Jakob Then, Philippe Ringler, Joachim Butzer, Thomas Juroschek, Christian Klein, Tilman Schlothauer, Laurent Larivière
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
TRIM21 is a pivotal effector in the immune system, orchestrating antibody-mediated responses and modulating immune signaling. In this comprehensive study, we focus on the interaction of TRIM21 with Fc engineered antibodies and subsequent implications
Externí odkaz:
https://doaj.org/article/152da4a7b8dd4fd591df1938822e36c4
Autor:
Gregor P. Lotz, Achim Lutz, Meret Martin-Facklam, Andre Hansbauer, Eginhard Schick, Ekkehard Moessner, Michael Antony, Thomas Stuchly, Maria Viert, Ralf J. Hosse, Anne Freimoser-Grundschober, Christian Klein, Martin Schäfer, Mirko Ritter, Kay-Gunnar Stubenrauch
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
An appropriately designed pharmacokinetic (PK) assay that is sensitive for anti-drug antibody (ADA) impact on relevant exposure is an alternative strategy to understand the neutralizing potential of ADAs. However, guidance on how to develop such PK a
Externí odkaz:
https://doaj.org/article/18341a26efd34158ae91f7ef9c0ff3f2
Autor:
Gaёl M. Vos, Kevin C. Hooijschuur, Zeshi Li, John Fjeldsted, Christian Klein, Robert P. de Vries, Javier Sastre Toraño, Geert-Jan Boons
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract O-acetylation is a common modification of sialic acids that has been implicated in a multitude of biological and disease processes. A lack of analytical methods that can determine exact structures of sialic acid variants is a hurdle to deter
Externí odkaz:
https://doaj.org/article/033979f4999e416c953fd011e0e3a6b2
Autor:
Anna Spreafico, Eva Muñoz Couselo, Anja Irmisch, Juliana Bessa, George Au-Yeung, Oliver Bechter, Inge Marie Svane, Miguel F. Sanmamed, Valentina Gambardella, Meredith McKean, Margaret Callahan, Reinhard Dummer, Christian Klein, Pablo Umaña, Nicole Justies, Florian Heil, Linda Fahrni, Eugenia Opolka-Hoffmann, Inja Waldhauer, Conrad Bleul, Roland F. Staack, Vaios Karanikas, Stephen Fowler
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionAlthough checkpoint inhibitors (CPIs) have improved outcomes for patients with metastatic melanoma, those progressing on CPIs have limited therapeutic options. To address this unmet need and overcome CPI resistance mechanisms, novel immun
Externí odkaz:
https://doaj.org/article/1b6cf328c2214d24859fac4cbcd710e0
Publikováno v:
Photonics, Vol 11, Iss 6, p 546 (2024)
In order to improve the data productivity of a wind tunnel test, the model under investigation in the wind tunnel is moved continuously with a predetermined constant angular speed in the so-called pitch–traverse mode. Alternatively, the wind tunnel
Externí odkaz:
https://doaj.org/article/e09c9a2be4414f3590b8e1d089eb670e