Supplemental Figure Legends from Notch4 Signaling Induces a Mesenchymal–Epithelial–like Transition in Melanoma Cells to Suppress Malignant Behaviors

Autor: Helmut Schaider, Helmut Bergler, Meenhard Herlyn, Christine Hafner, Melitta Kitzwoegerer, Heimo Breiteneder, Dinoop Ravindran Menon, Ulrich Popper, Christian Wels, Heinz Hammerlindl, Ehsan Bonyadi Rad

Supplemental Figure Legends for Supplemental Figures 1 to 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0868ca7dbb4395e45d6dd8aa0602f57b
https://doi.org/10.1158/0008-5472.22410959

Supplemental Materials and Mehods from Notch4 Signaling Induces a Mesenchymal–Epithelial–like Transition in Melanoma Cells to Suppress Malignant Behaviors

Autor: Helmut Schaider, Helmut Bergler, Meenhard Herlyn, Christine Hafner, Melitta Kitzwoegerer, Heimo Breiteneder, Dinoop Ravindran Menon, Ulrich Popper, Christian Wels, Heinz Hammerlindl, Ehsan Bonyadi Rad

Supplemental Materials and Methods used to create Supplemental Figures only in addition to Materials and Methods listed in the main manuscript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84199b9bba13cd2b02b63ead794c7f08
https://doi.org/10.1158/0008-5472.22410953

Notch4 Signaling Induces a Mesenchymal–Epithelial–like Transition in Melanoma Cells to Suppress Malignant Behaviors

Autor: Ulrich Popper, Christine Hafner, Heinz Hammerlindl, Melitta Kitzwoegerer, Dinoop Ravindran Menon, Meenhard Herlyn, Christian Wels, Helmut Bergler, Ehsan Bonyadi Rad, Helmut Schaider, Heimo Breiteneder

Publikováno v: Cancer Research. 76:1690-1697

The effects of Notch signaling are context-dependent and both oncogenic and tumor-suppressive functions have been described. Notch signaling in melanoma is considered oncogenic, but clinical trials testing Notch inhibition in this malignancy have not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c303398bd30ef43996befdf4ae9d310f
https://doi.org/10.1158/0008-5472.can-15-1722

TGF-β1 and TNF-α differentially regulate Twist1 mediated resistance towards BRAF/MEK inhibition in melanoma

Autor: Johanna M. Brandner, Heike Knausz, Johanne Lade-Keller, Shripad Joshi, Helmut Schaider, Christian Wels, Ehsan Bonyadi Rad, Dinoop Ravindran Menon

Publikováno v: Menon, D R, Wels, C, Bonyadi Rad, E, Joshi, S, Knausz, H, Lade-Keller, J, Brandner, J M & Schaider, H 2013, ' TGF-β1 and TNF-α differentially regulate Twist1 mediated resistance towards BRAF/MEK inhibition in melanoma ', Pigment Cell & Melanoma Research, vol. 26, no. 6, pp. 912-6 . https://doi.org/10.1111/pcmr.12139

Summary: Resistance to BRAF and MEK inhibition is a common phenomenon in melanoma. Cytokines and transcription factors have been attributed to contribute to the loss of sensitivity towards these inhibitors. Here, we show that transforming growth fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35fbbda5507707446a30f8bb5a02246
https://doi.org/10.1111/pcmr.12139

Transcriptional Activation of ZEB1 by Slug Leads to Cooperative Regulation of the Epithelial–Mesenchymal Transition-Like Phenotype in Melanoma

Autor: Helmut Bergler, P. Koefinger, Christian Wels, Helmut Schaider, Shripad Joshi

Publikováno v: Journal of Investigative Dermatology. 131(9):1877-1885

The E-box binding zinc finger transcription factors Slug and ZEB1 are important repressors of E-cadherin, contributing to epithelial-mesenchymal transition (EMT) in primary epithelial cancers. Activator or repressor status of EMT transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212e1f3d375db7717d367b8d411d85b9