Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Christian, Rosenmund"'
Autor:
Mathieu Favier, Elena Martin Garcia, Romain Icick, Camille de Almeida, Joachim Jehl, Mazarine Desplanque, Johannes Zimmermann, Annabelle Henrion, Nina Mansouri-Guilani, Coline Mounier, Svethna Ribeiro, Fiona Henderson, Andrea Geoffroy, Sebastien Mella, Odile Poirel, Véronique Bernard, Véronique Fabre, Yulong Li, Christian Rosenmund, Stéphane Jamain, Florence Vorspan, Alexandre Mourot, Philibert Duriez, Leora Pinhas, Rafael Maldonado, Nicolas Pietrancosta, Stéphanie Daumas, Salah El Mestikawy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Cholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3 (VGLUT3) which allows them to regulate the striatal network with glutamate and acetylcholine (ACh). In addition, VGLUT3-dependent glutamate increases ACh
Externí odkaz:
https://doaj.org/article/92f0421dd9334d49b5771f81a762f0c7
Autor:
Ekaterina Borisova, Andrew G. Newman, Marta Couce Iglesias, Rike Dannenberg, Theres Schaub, Bo Qin, Alexandra Rusanova, Marisa Brockmann, Janina Koch, Marieatou Daniels, Paul Turko, Olaf Jahn, David R. Kaplan, Marta Rosário, Takao Iwawaki, Christian M. T. Spahn, Christian Rosenmund, David Meierhofer, Matthew L. Kraushar, Victor Tarabykin, Mateusz C. Ambrozkiewicz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract The mammalian neocortex comprises an enormous diversity regarding cell types, morphology, and connectivity. In this work, we discover a post-transcriptional mechanism of gene expression regulation, protein translation, as a determinant of co
Externí odkaz:
https://doaj.org/article/66af00ce766642a5b9c7bd2aa0b9eb91
Publikováno v:
eLife, Vol 12 (2024)
The SNARE proteins are central in membrane fusion and, at the synapse, neurotransmitter release. However, their involvement in the dual regulation of the synchronous release while maintaining a pool of readily releasable vesicles remains unclear. Usi
Externí odkaz:
https://doaj.org/article/a7423aeb6b7a41ea8293d52ddaa15933
Publikováno v:
eLife, Vol 12 (2023)
Optical report of neurotransmitter release allows visualisation of excitatory synaptic transmission. Sensitive genetically-encoded fluorescent glutamate reporters operating with a range of affinities and emission wavelengths are available. However, w
Externí odkaz:
https://doaj.org/article/87bbaa55828d459197c6872174b70bca
Publikováno v:
eLife, Vol 11 (2022)
SNAREs are undoubtedly one of the core elements of synaptic transmission. Contrary to the well characterized function of their SNARE domains bringing the plasma and vesicular membranes together, the level of contribution of their juxtamembrane domain
Externí odkaz:
https://doaj.org/article/afeaa0a8a25c48c9841b22d071c15436
Autor:
Marcial Camacho, Bradley Quade, Thorsten Trimbuch, Junjie Xu, Levent Sari, Josep Rizo, Christian Rosenmund
Publikováno v:
eLife, Vol 10 (2021)
Munc13-1 plays a central role in neurotransmitter release through its conserved C-terminal region, which includes a diacyglycerol (DAG)-binding C1 domain, a Ca2+/PIP2-binding C2B domain, a MUN domain and a C2C domain. Munc13-1 was proposed to bridge
Externí odkaz:
https://doaj.org/article/f74364d8bc6c4f60aedc50002b36330a
Autor:
Gülçin Vardar, Andrea Salazar-Lázaro, Marisa Brockmann, Marion Weber-Boyvat, Sina Zobel, Victor Wumbor-Apin Kumbol, Thorsten Trimbuch, Christian Rosenmund
Publikováno v:
eLife, Vol 10 (2021)
Syntaxin-1 (STX1) and Munc18-1 are two requisite components of synaptic vesicular release machinery, so much so synaptic transmission cannot proceed in their absence. They form a tight complex through two major binding modes: through STX1’s N-pepti
Externí odkaz:
https://doaj.org/article/55b4807767164058a2892123920a2a74
Autor:
Sami Zaqout, Kathrin Blaesius, Yuan-Ju Wu, Stefanie Ott, Nadine Kraemer, Lena-Luise Becker, Marta Rosário, Christian Rosenmund, Ulf Strauss, Angela M. Kaindl
Publikováno v:
Neurobiology of Disease, Vol 129, Iss , Pp 130-143 (2019)
Congenital microcephaly is highly associated with intellectual disability. Features of autosomal recessive primary microcephaly subtype 3 (MCPH3) also include hyperactivity and seizures. The disease is caused by biallelic mutations in the Cyclin-depe
Externí odkaz:
https://doaj.org/article/d93807af9cd24d4c88905df5b032fea0
Autor:
Pascal Fenske, M. Katharina Grauel, Marisa M. Brockmann, Anja L. Dorrn, Thorsten Trimbuch, Christian Rosenmund
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Recently developed technology to differentiate induced pluripotent stem cells (iPSCs) into human induced neurons (iNs) provides an exciting opportunity to study the function of human neurons. However, functional characterisations of iNs have
Externí odkaz:
https://doaj.org/article/a865c8d717e04bdcb85579ff705a28ef
Autor:
Marisa M. Brockmann, Fereshteh Zarebidaki, Marcial Camacho, M. Katharina Grauel, Thorsten Trimbuch, Thomas C. Südhof, Christian Rosenmund
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107960- (2020)
Summary: At the presynaptic active zone, action-potential-triggered neurotransmitter release requires that fusion-competent synaptic vesicles are placed next to Ca2+ channels. The active zone resident proteins RIM, RBP, and Munc13 are essential contr
Externí odkaz:
https://doaj.org/article/7763280415ec449685a6a81ebc00a72b