Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Christian, Röver"'
Autor:
Thomas Lehnert, Christian Röver, Sascha Köpke, Jordi Rio, Declan Chard, Andrea V. Fittipaldo, Tim Friede, Christoph Heesen, Anne C. Rahn
Publikováno v:
Systematic Reviews, Vol 11, Iss 1, Pp 1-13 (2022)
Abstract Background Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system with an increasing worldwide prevalence. Since 1993, more than 15 disease-modifying immunotherapies (DMTs) have been licenced and ha
Externí odkaz:
https://doaj.org/article/2f84c4fd07e7400a85847eff7206cbd2
Publikováno v:
ERJ Open Research, Vol 8, Iss 1 (2022)
A decreasing trend in exacerbation rates has been observed in COPD. Because mortality is linked to exacerbations, it is of interest to investigate whether a similar time trend is also present in mortality rates. We performed a systematic review of pl
Externí odkaz:
https://doaj.org/article/76aa2ea2d47047c4bd5cf28066362e3c
Autor:
Jayakrishna Ambati, Joseph Magagnoli, Hannah Leung, Shao-bin Wang, Chris A. Andrews, Dongxu Fu, Akshat Pandey, Srabani Sahu, Siddharth Narendran, Shuichiro Hirahara, Shinichi Fukuda, Jian Sun, Lekha Pandya, Meenakshi Ambati, Felipe Pereira, Akhil Varshney, Tammy Cummings, James W. Hardin, Babatunde Edun, Charles L. Bennett, Kameshwari Ambati, Benjamin J. Fowler, Nagaraj Kerur, Christian Röver, Norbert Leitinger, Brian C. Werner, Joshua D. Stein, S. Scott Sutton, Bradley D. Gelfand
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Inflammasome activation may contribute to type 2 diabetes, but whether targeting inflammasome is beneficial is unclear. Here the authors show that repurposing nucleoside reverse transcriptase inhibitors for inhibiting inflammasome activation is assoc
Externí odkaz:
https://doaj.org/article/3c663125a9b94db7a11c2309f51581c5
Autor:
Christian Röver
Publikováno v:
Journal of Statistical Software, Vol 93, Iss 1, Pp 1-51 (2020)
The random-effects or normal-normal hierarchical model is commonly utilized in a wide range of meta-analysis applications. A Bayesian approach to inference is very attractive in this context, especially when a meta-analysis is based only on few studi
Externí odkaz:
https://doaj.org/article/db39461b5a31463dbab2aaf03c536aa1
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic und
Externí odkaz:
https://doaj.org/article/de25fce04ad84965b91f2ff0a486fdfc
Publikováno v:
BMC Medical Research Methodology, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Standard random-effects meta-analysis methods perform poorly when applied to few studies only. Such settings however are commonly encountered in practice. It is unclear, whether or to what extent small-sample-size behaviour can be
Externí odkaz:
https://doaj.org/article/38085691867c4b2bb9254dce2e009543
Autor:
Leonard Bergau, Rik Willems, David J. Sprenkeler, Thomas H. Fischer, Panayota Flevari, Gerd Hasenfuß, Dimitrios Katsaras, Aleksandra Kirova, Stephan E. Lehnart, Lars Lüthje, Christian Röver, Joachim Seegers, Samuel Sossalla, Albert Dunnink, Rajevaa Sritharan, Anton E. Tuinenburg, Bert Vandenberk, Marc A. Vos, Sofieke C. Wijers, Tim Friede, Markus Zabel
Publikováno v:
Data in Brief, Vol 21, Iss , Pp 2110-2116 (2018)
This data article features supplementary figures and tables related to the article “Differential Multivariable risk prediction of appropriate shock vs. competing mortality – a prospective cohort study to estimate benefits from implantable cardiov
Externí odkaz:
https://doaj.org/article/9918dc415278414a87eaa3a122004b1a
Autor:
Tim Friede, Martin Posch, Sarah Zohar, Corinne Alberti, Norbert Benda, Emmanuelle Comets, Simon Day, Alex Dmitrienko, Alexandra Graf, Burak Kürsad Günhan, Siew Wan Hee, Frederike Lentz, Jason Madan, Frank Miller, Thomas Ondra, Michael Pearce, Christian Röver, Artemis Toumazi, Steffen Unkel, Moreno Ursino, Gernot Wassmer, Nigel Stallard
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-9 (2018)
Abstract Where there are a limited number of patients, such as in a rare disease, clinical trials in these small populations present several challenges, including statistical issues. This led to an EU FP7 call for proposals in 2013. One of the three
Externí odkaz:
https://doaj.org/article/9b388cef7daa4326aa630be227e4381e
Publikováno v:
Statistics in Medicine
Statistics in Medicine, 2022, 41 (20), pp.3915-3940. ⟨10.1002/sim.9484⟩
Statistics in Medicine, 2022, 41 (20), pp.3915-3940. ⟨10.1002/sim.9484⟩
Phase I early-phase clinical studies aim at investigating the safety and the underlying dose-toxicity relationship of a drug or combination. While little may still be known about the compound's properties, it is crucial to consider quantitative infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897fe4b52e53ec72177695b4494df8cf
https://doi.org/10.1002/sim.9484
https://doi.org/10.1002/sim.9484
Publikováno v:
Statistics in Medicine.
In Bayesian meta-analysis, the specification of prior probabilities for the between-study heterogeneity is commonly required, and is of particular benefit in situations where only few studies are included. Among the considerations in the set-up of su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe6be480e2c114272709cb9c85b157b
https://doi.org/10.1002/sim.9731
https://doi.org/10.1002/sim.9731