Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Christian, Otoul"'
Autor:
Mohammad Mahmud, Charles Wade, Sarah Jawad, Zaeem Hadi, Christian Otoul, Rafal M. Kaminski, Pierandrea Muglia, Irena Kadiu, Eugenii Rabiner, Paul Maguire, David R. Owen, Michael R. Johnson
Publikováno v:
Frontiers in Neuroimaging, Vol 2 (2023)
ObjectiveTranslocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in healt
Externí odkaz:
https://doaj.org/article/8ac866fbfb8544ee9f7ba34f2fbbf4c0
Autor:
David Sciberras, Christian Otoul, Françoise Lurquin, John Smeraglia, Aurélia Lappert, Steven De Bruyn, Jan Jaap van Lier
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 1, Pp n/a-n/a (2019)
Abstract In this phase I, single‐center, open‐label study of ten heathy adults (18‐45 years; NCT02647697), the PK, safety, and tolerability profile of radiprodil oral suspension in healthy adults were assessed, as well as two PK microsampling t
Externí odkaz:
https://doaj.org/article/ca51acea655646f4a6c7dca2f1ec5120
Autor:
Mohammad Mahmud, Charles Wade, Sarah Jawad, Zaeem Hadi, Christian Otoul, Rafal M. Kaminski, Pierandrea Muglia, Irena Kadiu, Eugenii Rabiner, Paul Maguire, David R. Owen, Michael R. Johnson
ObjectiveTranslocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39c96e1791dc3f6c10705bda7abe5f5
http://hdl.handle.net/10044/1/103496
http://hdl.handle.net/10044/1/103496
Autor:
Mohammad Mahmud, Charles Wade, Sarah Jawad, Zaeem Hadi, Christian Otoul, Rafal M. Kaminski, Pierandrea Muglia, Irena Kadiu, Eugenii A. Rabiner, Paul Maguire, David R. Owen, Michael R. Johnson
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa19ff1696b928d5f2b09f794460c620
https://doi.org/10.2139/ssrn.4029510
https://doi.org/10.2139/ssrn.4029510
Autor:
Paul Martin, Joël Mercier, Jean-Marie Nicolas, Mika Naganawa, Armel Stockis, Yiyun Huang, Samantha Rossano, Christian Otoul, Sjoerd J. Finnema, Yihuan Lu, Richard E. Carson, Takuya Toyonaga, Nabeel Nabulsi, Steven De Bruyn, R. Paul Maguire, Jim Ropchan
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 40:1890-1901
11C-UCB-J is a positron emission tomography (PET) radioligand that has been used in humans for synaptic vesicle glycoprotein 2A (SV2A) imaging and as a potential synaptic density marker. The centrum semiovale (CS) is a proposed reference region for n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d7f7dc915bfdc57b51e32236479da6b
https://doi.org/10.1177/0271678x19879230
https://doi.org/10.1177/0271678x19879230
Autor:
Katie Melton, Oliver Stumpp, Shyamal Patel, Babak Boroojerdi, John Wright, Jake Phillips, D. Tatla, Nikhil Mahadevan, Christian Otoul, Roozbeh Ghaffari, Nirav Sheth, Dolors Terricabras, Ellora Sen-Gupta, Kasper Claes, Briana Morey, Michael Markowitz
Publikováno v:
Parkinsonism & Related Disorders. 61:70-76
Introduction Clinical assessment of motor symptoms in Parkinson's disease (PD) is subjective and may not reflect patient real-world experience. This two-part pilot study evaluated the accuracy of the NIMBLE wearable biosensor patch (containing an acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3aea47f9bf7e0589f81525687bb871
https://doi.org/10.1016/j.parkreldis.2018.11.024
https://doi.org/10.1016/j.parkreldis.2018.11.024
Autor:
Jean-Marie Nicolas, Jonas Hannestad, Steven DeBruyn, Samantha Rossano, Yiyun Huang, Sjoerd J. Finnema, Mika Naganawa, Rafal M. Kaminski, Nabeel Nabulsi, Pierandrea Muglia, Christian Otoul, Hong Gao, Paul Martin, Joël Mercier, Henrik Klitgaard, Richard E. Carson, Armel Stockis, Shannan Henry, Richard Pracitto, David Matuskey, Sophie Kervyn, Ralph Paul Maguire
Publikováno v:
Epilepsia
Summary Objective Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that bind synaptic vesicle glycoprotein 2A (SV2A). In vitro and in vivo animal studies suggest faster brain penetration and SV2A occupancy (SO) after dosing with BRV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c8cac6fb964e16978fdb45714dd6ca
https://doi.org/10.1111/epi.14701
https://doi.org/10.1111/epi.14701
Autor:
Christian Wolf, Jagdev Sidhu, Christian Otoul, Dexter L Morris, Jennifer Cnops, Jorg Taubel, Barbara Bennett
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58438 (2013)
Lymphocyte inhibition by antagonism of α4 integrins is a validated therapeutic approach for relapsing multiple sclerosis (RMS).Investigate the effect of CDP323, an oral α4-integrin inhibitor, on lymphocyte biomarkers in RMS.Seventy-one RMS subjects
Externí odkaz:
https://doaj.org/article/51d60e745c2a4d8fa251d479697ccc5e
Autor:
Peter Colman, Chris Chamberlain, Geoffrey I Johnston, Falk Hiepe, Ann Ranger, C. Stach, Thomas Dörner, Linda C. Burkly, Murray B. Urowitz, Miren Zamacona, Christian Otoul
Publikováno v:
Annals of the Rheumatic Diseases. 76:1837-1844
ObjectivesSystemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease associated with diffuse immune cell dysfunction. CD40–CD40 ligand (CD40L) interaction activates B cells, antigen-presenting cells and platelets. CD40L blockade might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4831cecc7f411c17a4b3a69de0c8ac28
https://doi.org/10.1136/annrheumdis-2017-211388
https://doi.org/10.1136/annrheumdis-2017-211388
Autor:
Jonas Hannestad, Bernhard J. Steinhoff, Massimiliano Germani, Koen Van Laere, Konrad J. Werhahn, Christian Otoul, David Sciberras, Manuel Toledo, Christian Brandt, Rafal M. Kaminski, Marian Majoie, Steven DeBruyn, Pierandrea Muglia, Wim Van Paesschen, Brigitte Lacroix, Elizabeth Webster
Publikováno v:
Brain Communications
Brain Communications, 2(2):183. Oxford University Press
Brain Communications, 2(2):183. Oxford University Press
Therapeutic options for patients with treatment-resistant epilepsy represent an important unmet need. Addressing this unmet need was the main factor driving the drug discovery program that led to the synthesis of padsevonil, a first-in-class antiepil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f729a1db940c38ae2356fe351d63866
https://doi.org/10.1093/braincomms/fcaa183
https://doi.org/10.1093/braincomms/fcaa183