Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christian, Metallo"'
Autor:
Kevin T. Eade, Brendan Robert E. Ansell, Sarah Giles, Regis Fallon, Sarah Harkins-Perry, Takayuki Nagasaki, Simone Tzaridis, Martina Wallace, Elizabeth A. Mills, Samaneh Farashi, Alec Johnson, Lydia Sauer, Barbara Hart, M. Elena Diaz-Rubio, Melanie Bahlo, Christian Metallo, Rando Allikmets, Marin L. Gantner, Paul S. Bernstein, Martin Friedlander
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
Patient-derived induced pluripotent stem cells (iPSCs) provide a powerful tool for identifying cellular and molecular mechanisms of disease. Macular telangiectasia type 2 (MacTel) is a rare, late-onset degenerative retinal disease with an extremely h
Externí odkaz:
https://doaj.org/article/c36953378fea49618ef3b23be50c87cb
Autor:
Udit Parekh, Daniella McDonald, Amir Dailamy, Yan Wu, Thekla Cordes, Kun Zhang, Ann Tipps, Christian Metallo, Prashant Mali
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103149- (2021)
Summary: Deconstructing tissue-specific effects of genes and variants on proliferation is critical to understanding cellular transformation and systematically selecting cancer therapeutics. This requires scalable methods for multiplexed genetic scree
Externí odkaz:
https://doaj.org/article/1c52608ac0074fbba45fcc690eb6237a
Autor:
Jason K. Sicklick, Christian Metallo, Olivier Harismendy, Paul T. Fanta, Scott M. Lippman, Razelle Kurzrock, Michael C. Heinrich, Christopher L. Corless, Sunil J. Advani, Sam Li, Rowan Ustoy, Sangkyu Noh, Vipul Sheth, Thekla Cordes, Joseph Aguilera, Sudeep Banerjee, Hyunho Yoon, Chih-Min Tang, Adam M. Burgoyne, Avi Kumar, Shruti Bhargava, Mayra Yebra
Fig. S4. Response of GIST KIT mutant cells to TKI inhibitors A-B. Cell viability of SDH-wildtype (or KIT mutant) GIST cells (GIST-T1 and GIST882 cells) after treatment with imatinib (A) and sunitinib (B) at 72 h as measured by MTT viability assay. Pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8be2017fa7d0140578e22befecda43
https://doi.org/10.1158/1078-0432.22482641
https://doi.org/10.1158/1078-0432.22482641
Autor:
Jason K. Sicklick, Christian Metallo, Olivier Harismendy, Paul T. Fanta, Scott M. Lippman, Razelle Kurzrock, Michael C. Heinrich, Christopher L. Corless, Sunil J. Advani, Sam Li, Rowan Ustoy, Sangkyu Noh, Vipul Sheth, Thekla Cordes, Joseph Aguilera, Sudeep Banerjee, Hyunho Yoon, Chih-Min Tang, Adam M. Burgoyne, Avi Kumar, Shruti Bhargava, Mayra Yebra
Contains supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181de4cd74d50dc3ffde403fde316dd6
https://doi.org/10.1158/1078-0432.22482656.v1
https://doi.org/10.1158/1078-0432.22482656.v1
Autor:
Jason K. Sicklick, Christian Metallo, Olivier Harismendy, Paul T. Fanta, Scott M. Lippman, Razelle Kurzrock, Michael C. Heinrich, Christopher L. Corless, Sunil J. Advani, Sam Li, Rowan Ustoy, Sangkyu Noh, Vipul Sheth, Thekla Cordes, Joseph Aguilera, Sudeep Banerjee, Hyunho Yoon, Chih-Min Tang, Adam M. Burgoyne, Avi Kumar, Shruti Bhargava, Mayra Yebra
Purpose:Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract, with mutant succinate dehydrogenase (SDH) subunits (A–D) comprising less than 7.5% (i.e., 150–200/year) of new cases annually in the United St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e4847eff67a5cec0e9bc4475d18271
https://doi.org/10.1158/1078-0432.c.6530975.v1
https://doi.org/10.1158/1078-0432.c.6530975.v1
Autor:
Jason K. Sicklick, Christian Metallo, Olivier Harismendy, Paul T. Fanta, Scott M. Lippman, Razelle Kurzrock, Michael C. Heinrich, Christopher L. Corless, Sunil J. Advani, Sam Li, Rowan Ustoy, Sangkyu Noh, Vipul Sheth, Thekla Cordes, Joseph Aguilera, Sudeep Banerjee, Hyunho Yoon, Chih-Min Tang, Adam M. Burgoyne, Avi Kumar, Shruti Bhargava, Mayra Yebra
Supplementary Table S1. Short Tandem Repeat (STR) Loci of mSDH GIST models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7200ef5abeed2e2c848726da1e573494
https://doi.org/10.1158/1078-0432.22482635
https://doi.org/10.1158/1078-0432.22482635
Autor:
Liezl Maree, Eric Leonardis, Sergei Gepshtein, Thomas Albright, Kristianna Hitchcock, Nick Andrews, Eiman Azim, Samuel Pfaff, Christian Metallo, Talmo Pereira
Publikováno v:
Biological Psychiatry. 93:S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::010d7337097c8abca271a8f0f8f03cd6
https://doi.org/10.1016/j.biopsych.2023.02.038
https://doi.org/10.1016/j.biopsych.2023.02.038
Autor:
Christian Metallo, Michal Handzlik, Jivani Gengatharan, Katie Frizzi, Grace McGregor, Cameron Martino, Gibraan Rahman, Antonio Gonzalez, Ana Moreno, Courtney Green, Terry Lin, Yoichiro Ideguchi, Regis Fallon, Amandine Chaix, Martina Wallace, Prashant Mali, Marin Gantner, Nigel Calcutt, Robin Knight
Type 2 diabetes represents a disease spectrum in which chronic metabolic dysfunction damages multiple organ systems including liver, kidneys, and peripheral nerves1,2. While onset and progression of these co-morbidities are linked with insulin resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b3b116fb581000c93d47aab8e70791f
https://doi.org/10.21203/rs.3.rs-1189916/v1
https://doi.org/10.21203/rs.3.rs-1189916/v1
Publikováno v:
Circulation Research. 121
Despite limited regenerative capacity, compensatory mechanisms in cardiomyocytes may help maintain their function as we age, e.g. vinculin expression and localization to intercalated discs and costameres in aged organisms. This molecular mechanism, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3cb559ed65aaee3559d73aa3cfac5d
https://doi.org/10.1161/res.121.suppl_1.127
https://doi.org/10.1161/res.121.suppl_1.127