Krebsprädispositionssyndrome – eine Herausforderung nicht nur bei Kindern: Interview mit Prof. Dr. Christian Kratz, Direktor der Klinik für Pädiatrische Hämatologie und Onkologie der Medizinischen Hochschule Hannover. (German)

Publikováno v: Best Practice Onkologie; Apr2022, Vol. 17 Issue 4, p172-177, 6p

Association of Country-Specific Socioeconomic Factors With Survival of Patients Who Experience Severe Classic Acute Graft-vs.-Host Disease After Allogeneic Hematopoietic Cell Transplantation. An Analysis From the Transplant Complications Working Party of the EBMT

Autor: Andrzej Frankiewicz, Christophe Peczynski, Sebastian Giebel, Alenca Harrington, Gerard Socié, Dietger Niederwieser, Christoph Scheid, Martin Bornhäuser, Nicolaus Kröger, Ahmet Elmaagacli, Boris Afanasyev, Peter Dreger, Claudia Rössig, Didier Blaise, Christian Kratz, Ibrahim Yakoub-Agha, Bernhard Kremens, Charlotte Marie Niemeyer, Gerald Wulf, Igor Blau, Olaf Penack, Hildegard Greinix, Grzegorz W. Basak

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Acute graft-vs.-host disease (aGvHD) is one of the most frequent causes of transplant-related mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). Its treatment is complex and costly. The aim of this study was to retrospecti

Externí odkaz: https://doaj.org/article/322ecd6434084545b3444a71e3918c42

Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group

Autor: Stefanie Junk, Elke Schaeffeler, Martin Zimmermann, Anja Möricke, Rita Beier, Peter Schütte, Birthe Fedders, Julia Alten, Laura Hinze, Norman Klein, Andreas Kulozik, Martina Muckenthaler, Rolf Koehler, Arndt Borkhardt, Jayaram Vijayakrishnan, David Ellinghaus, Michael Forster, Andre Franke, Astrid Wintering, Christian Kratz, Martin Schrappe, Matthias Schwab, Richard Houlston, Gunnar Cario, Martin Stanulla

Background Characterization of clinical phenotypes in context with tumor and host genomic information can aid in the development of more effective and less toxic risk-adapted and targeted treatment strategies. To analyze the impact of therapy-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dea6150bdd3c4dad2748b61aacb46e
https://zenodo.org/record/7539533

Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance

Autor: Lee Yi Yen, Melyssa Aronson, Carol J. Swallow, Cynthia Hawkins, Lara Reichman, Rebecca C. Luiten, Sumita Roy, Michal Zapotocky, Patrick Tomboc, Christian Kratz, Michael Osborn, Junne Kamihara, Ayse Bahar Ercan, Jamie L. Maciaszek, Vanessa Bianchi, Benjamin Oshrine, Hagit N. Baris, Ossama M. Maher, Mohsin Rashid, Sara Rhode, Sharon Gardner, Annika Bronsema, David S. Ziegler, An Van Damme, Monica Newmark, Mithra Ghalibafian, Heather Hampel, Jordan R. Hansford, Vahid Fallah Azad, Michael P. Link, Simon C. Ling, Marc Remke, Shayna Zelcer, Deborah T. Blumenthal, Isabelle Scheers, Rebecca Loret De Mola, Syed Ahmer Hamid, Vanan MagimairajanIssai, Kim E. Nichols, Saunders Hsu, Catherine Goudie, Naureen Mushtaq, Ira Winer, Abeer Al-Battashi, Garth Nicholas, Roula Farah, Kami Wolfe Schneider, Rejin Kebudi, Jan Rapp, Gregory Thomas, Helen Toledano, Alvaro Lassaletta, Anne Bendel, Jeffrey Knipstein, Musa Alharbi, Gadi Abebe-Campino, Rose B. McGee, Anirban Das, Uri Tabori, Donald Basel, Alyssa Reddy, Melissa Edwards, Scott Lindhorst, Craig Harlos, Bailey Gallinger, Elizabeth Cairney, Anita Villani, Valerie Larouche, Rachel Pearlman, Maude Blundell, Gary Mason, David Sumerauer, Magnus Sabel, Aghiad Chamdin, Leslie Taylor, David Malkin, William D. Foulkes, Maura Massimino, Catherine Gilpin, Eric Bouffet, Miriam Bornhorst, Carol Durno, Enrico Opocher, Nobuko Hijiya, Zehavit Frenkel, David Samuel, Michal Lurye, Stefanie Zimmermann, Shani Caspi, Stefano Chiaravalli, David Gass, Eshetu G. Atenafu, Shlomi Constantini, Shay Ben-Shachar, Michal Yalon, Rina Dvir, Daniel Pettee, Bruce Crooks, Santanu Sen, Carl Koschmann, Raymond Bedgood, Theodore Nicolaides, Duncan Stearns, Yael Goldberg, Melissa Galati, Gabriel Robbins

Publikováno v: Paediatrics Publications
Journal of Clinical Oncology, Vol. 39, no.25, p. 2779-2790 (2021)

PURPOSE Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors. We designed a surveillance protocol for early tumor detection i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc31eca9b2efe8b55ac14084ca85e170
https://doi.org/10.1200/jco.20.02636

MEDB-14. Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome

Autor: Anna Kolodziejczak, Lea Guerrini-Rousseau, Julien Masliah Planchon, Jonas Ecker, Florian Selt, Martin Mynarek, Denise Obrecht, Martin Sill, Steffen Hirsch, Dominik Sturm, Sebastian M Waszak, Vijay Ramaswamy, Virve Pentikainen, Haci Ahmet Demir, Steven C Clifford, Ed Schwalbe, Luca Massimi, Matija Snuderl, Kristyn Galbraith, Matthias A Karajannis, Katie Hill, Bryan Li, Christine L White, Shelagh Redmond, Loizou Loizos, Marcus Jakob, Uwe Kordes, Irene Schmid, Julia Hauer, Claudia Blattmann, Maria Filippidou, Wolfram Scheurlen, Udo Kontny, Kerstin Grund, Christian Sutter, Torsten Pietsch, Cornelis M van Tilburg, Stephan Frank, Denis M Schewe, David Malkin, Michael D Taylor, Uri Tabori, Eric Bouffet, Marcel Kool, Felix Sahm, Andreas von Deimling, Andrey Korshunov, Katja Von Hoff, Christian Kratz, David T W Jones, Stefan Rutkowski, Olaf Witt, Gaelle Bougeard, Kristian W Pajtler, Stefan M Pfister, Franck Bourdeaut, Till Milde

PURPOSE: The prognosis for SHH-medulloblastoma (MB) patients with Li-Fraumeni syndrome (LFS) is poor. Due to lack of comprehensive data for these patients, it is challenging to establish effective therapeutic recommendations. We here describe the lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15469ae7e19a9bc211d9763086a10d58
https://nrl.northumbria.ac.uk/id/eprint/49500/1/noac079.389.pdf