Zobrazeno 1 - 10
of 504
pro vyhledávání: '"Christian, Hertweck"'
Autor:
Sebastian Schaefer, Raghav Vij, Jakob L. Sprague, Sophie Austermeier, Hue Dinh, Peter R. Judzewitsch, Sven Müller-Loennies, Taynara Lopes Silva, Eric Seemann, Britta Qualmann, Christian Hertweck, Kirstin Scherlach, Thomas Gutsmann, Amy K. Cain, Nathaniel Corrigan, Mark S. Gresnigt, Cyrille Boyer, Megan D. Lenardon, Sascha Brunke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract More than two million people worldwide are affected by life-threatening, invasive fungal infections annually. Candida species are the most common cause of nosocomial, invasive fungal infections and are associated with mortality rates above 4
Externí odkaz:
https://doaj.org/article/4855006eb2384c85b16fca8c8d5c88bf
Autor:
Alina Hoffmann, Ursula Steffens, Boris Maček, Mirita Franz-Wachtel, Kay Nieselt, Theresa Anisja Harbig, Kirstin Scherlach, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum
Publikováno v:
mSphere, Vol 9, Iss 5 (2024)
ABSTRACT Cervimycins A–D are bis-glycosylated polyketide antibiotics produced by Streptomyces tendae HKI 0179 with bactericidal activity against Gram-positive bacteria. In this study, cervimycin C (CmC) treatment caused a spaghetti-like phenotype i
Externí odkaz:
https://doaj.org/article/4833b7c76779426b9186573341897b4a
Autor:
Johannes Rassbach, Nathalie Hilsberg, Veit G. Haensch, Sebastian Dörner, Julia Gressler, Robin Sonnabend, Caroline Semm, Kerstin Voigt, Christian Hertweck, Markus Gressler
Publikováno v:
Fungal Biology and Biotechnology, Vol 10, Iss 1, Pp 1-21 (2023)
Abstract Background Fungi are prolific producers of bioactive small molecules of pharmaceutical or agricultural interest. The secondary metabolism of higher fungi (Dikarya) has been well-investigated which led to > 39,000 described compounds. However
Externí odkaz:
https://doaj.org/article/d5f1c55dd07d40b4953a08ba0b4cb7f0
Autor:
Jan-Niklas Weber, Rieke Minner-Meinen, Maria Behnecke, Rebekka Biedendieck, Veit G. Hänsch, Thomas W. Hercher, Christian Hertweck, Lena van den Hout, Lars Knüppel, Simon Sivov, Jutta Schulze, Ralf-R. Mendel, Robert Hänsch, David Kaufholdt
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Molybdenum (Mo) as essential micronutrient for plants, acts as active component of molybdenum cofactor (Moco). Core metabolic processes like nitrate assimilation or abscisic-acid biosynthesis rely on Moco-dependent enzymes. Although a family
Externí odkaz:
https://doaj.org/article/f7b4b3b9883e405d8783d0d6572ba0d8
Autor:
Ingrid Richter, Zerrin Uzum, Philipp Wein, Evelyn M. Molloy, Nadine Moebius, Timothy P. Stinear, Sacha J. Pidot, Christian Hertweck
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTThe phytopathogenic fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans rhizoxinica) that produces a crucial virulence factor responsible for the characteristic symptoms of rice seedling blight. The persistence of thi
Externí odkaz:
https://doaj.org/article/0ac9d9780247406692793552e79084ad
Autor:
Philipp Wein, Katharina Dornblut, Sebastian Herkersdorf, Thomas Krüger, Evelyn M. Molloy, Axel A. Brakhage, Dirk Hoffmeister, Christian Hertweck
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT The soft rot pathogen Janthinobacterium agaricidamnosum causes devastating damage to button mushrooms (Agaricus bisporus), one of the most cultivated and commercially relevant mushrooms. We previously discovered that this pathogen releases t
Externí odkaz:
https://doaj.org/article/a43d816f69614a7983d9c4fbbdca3ee2
Autor:
Ingrid Richter, Silvia Radosa, Zoltán Cseresnyés, Iuliia Ferling, Hannah Büttner, Sarah P. Niehs, Ruman Gerst, Kirstin Scherlach, Marc Thilo Figge, Falk Hillmann, Christian Hertweck
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT The fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans rhizoxinica) for the production of the antimitotic toxin rhizoxin. Although rhizoxin is the causative agent of rice seedling blight, the toxinogenic bacterial-f
Externí odkaz:
https://doaj.org/article/27da3a3e12df45a180537acbc4fb32d2
Autor:
Gaurav Sharma, Salim T. Islam, Praveen Rahi, Mark W. Silby, Donato Giovannelli, Paula V. Welander, Monika Ehling-Schulz, Vasvi Chaudhry, Evelyn Molloy, Christian Hertweck, Sunil Mundra, Vipin Chandra Kalia, Rup Lal, Yogendra Singh, Edward Ruby, Christoph Weigel, Roberto Kolter
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
Externí odkaz:
https://doaj.org/article/e583555062a847b791cec7e9e6cd518e
Autor:
Alina Dietrich, Ursula Steffens, Mike Gajdiss, Anna-Lena Boschert, Jana Katharina Dröge, Christiane Szekat, Peter Sass, Imran T. Malik, Jan Bornikoel, Laura Reinke, Boris Maček, Mirita Franz-Wachtel, Kay Nieselt, Theresa Harbig, Kirstin Scherlach, Heike Brötz-Oesterhelt, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Resistance to antibiotics is an increasing problem and necessitates novel antibacterial therapies. The polyketide antibiotics cervimycin A to D are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-re
Externí odkaz:
https://doaj.org/article/0db489a7ff654f7297e365749f7a453f
Autor:
Kirstin Scherlach, Christian Hertweck
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Natural products are an important source of bioactive compounds and have versatile applications in different fields, but their discovery is challenging. Here, the authors review the recent developments in genome mining for discovery of natural produc
Externí odkaz:
https://doaj.org/article/10d94552f2ba40d684c9be1a898649d7