Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Christian, Harcken"'
Autor:
Koen Venken, Peggy Jacques, Céline Mortier, Mark E. Labadia, Tine Decruy, Julie Coudenys, Kathleen Hoyt, Anita L. Wayne, Robert Hughes, Michael Turner, Sofie Van Gassen, Liesbet Martens, Dustin Smith, Christian Harcken, Joseph Wahle, Chao-Ting Wang, Eveline Verheugen, Nadia Schryvers, Gaëlle Varkas, Heleen Cypers, Ruth Wittoek, Yves Piette, Lieve Gyselbrecht, Serge Van Calenbergh, Filip Van den Bosch, Yvan Saeys, Gerald Nabozny, Dirk Elewaut
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cel
Externí odkaz:
https://doaj.org/article/ddd72678135941fdb84362715749b1f1
Autor:
Helena Bassolas-Molina, Ernest Raymond, Mark Labadia, Joseph Wahle, Elena Ferrer-Picón, Mark Panzenbeck, Jie Zheng, Christian Harcken, Robert Hughes, Michael Turner, Dustin Smith, Elisabeth Calderón-Gómez, Míriam Esteller, Anna Carrasco, Maria Esteve, Isabella Dotti, Ana Maria Corraliza, Maria Carme Masamunt, Clàudia Arajol, Jordi Guardiola, Elena Ricart, Gerald Nabozny, Azucena Salas
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Background and Aims: Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants further study. Inhibition of retinoic acid-related orphan receptor gamma (RORγt), the mas
Externí odkaz:
https://doaj.org/article/b55be1679e7541e4b4c59b7858f59700
Autor:
Mary Flack, Sabrina Wiebe, Armin Schultz, Jianan Hui, Meera Ramanujam, Elliott Klein, Jürgen Steffgen, Alpana Gupta, Christian Harcken, Jing Wu, Xiujiang Li, Steven J. Padula, Sudha Visvanathan, Ewald Benediktus, Tobias Litzenburger, Fabian Müller, Andreas Hünnemeyer
Publikováno v:
British Journal of Clinical Pharmacology. 87:1824-1838
Aims To evaluate the safety, pharmacokinetics and pharmacodynamics of single- and multiple-rising doses (MRDs) of BI 705564 and establish proof of mechanism. Methods BI 705564 was studied in 2 placebo-controlled, Phase I clinical trials testing singl
Autor:
Nuruddeen D Lewis, Lori A Patnaude, Josephine Pelletier, Donald J Souza, Susan M Lukas, F James King, Jonathan D Hill, Dimitria E Stefanopoulos, Kelli Ryan, Sudha Desai, Donna Skow, Stefan G Kauschke, Andre Broermann, Daniel Kuzmich, Christian Harcken, Eugene R Hickey, Louise K Modis
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100883 (2014)
GPBAR1 is a G protein-coupled receptor that is activated by certain bile acids and plays an important role in the regulation of bile acid synthesis, lipid metabolism, and energy homeostasis. Recent evidence suggests that GPBAR1 may also have importan
Externí odkaz:
https://doaj.org/article/26efe3ddb1914034965ffa796c1b72fb
Autor:
Nuruddeen D Lewis, Akalushi Muthukumarana, Steven E Fogal, Laura Corradini, Dimitria E Stefanopoulos, Prathima Adusumalli, Josephine Pelletier, Mark Panzenbeck, Karen Berg, Melissa Canfield, Brian N Cook, Hossein Razavi, Daniel Kuzmich, Shawn Anderson, Devan Allard, Paul Harrison, Christine Grimaldi, Donald Souza, Christian Harcken, Ryan M Fryer, Louise K Modis, Maryanne L Brown
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105883 (2014)
Inflammation is associated with immune cells infiltrating into the inflammatory site and pain. CC chemokine receptor 1 (CCR1) mediates trafficking of leukocytes to sites of inflammation. However, the contribution of CCR1 to pain is incompletely under
Externí odkaz:
https://doaj.org/article/81669bfd30b848adb34caf77ca3b6e5b
Autor:
Kathleen Hoyt, Kim Fletcher, Christian Harcken, Steven Richard Brunette, T. Gregg Davis, Delphine Collin, Ryan M. Fryer, Robert Sibley, Thomas Wieckowski, Jörg P Hehn, Dustin Smith, Yin-Chao Tseng, Stanley Kugler, Csengery Johanna, Donald Souza, Liang Shuang, Michael Robert Turner, Mark E. Labadia, Donna Terenzio, Anita L. Wayne, Mark Panzenbeck, Wu Lifen, Robert Hughes
Publikováno v:
ACS Med Chem Lett
[Image: see text] The interleukin (IL)-23/T helper (Th)17 axis plays a critical role in autoimmune diseases, and there is an increasing number of biologic therapies that target IL-23 and IL-17. The transcription factor retinoic acid receptor-related
Publikováno v:
Expert opinion on investigational drugs. 28(5)
Background: An efficacious anti-inflammatory corticosteroid with reduced side effects has been long sought. We report the pooled results from three clinical proof-of-mechanism Phase I studies of BI 653048 in healthy subjects, a functionally selective
Autor:
Maurice A. Marsini, Joshuaine Grant, Jon C. Lorenz, Christian Harcken, Frederic G. Buono, Jonathan T. Reeves, Hossein Razavi
Publikováno v:
ACS Symposium Series ISBN: 9780841234321
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a36e6f41d98e48bc6e0f8ed35a62e81
https://doi.org/10.1021/bk-2019-1332.ch008
https://doi.org/10.1021/bk-2019-1332.ch008
Autor:
Christian Harcken, Sara Khalil, Donald Souza, Meera Ramanujam, Gerald Nabozny, Sayra J. Garcia, Elliott Klein, Janice Dimock, Mark Panzenbeck, Elise Seccareccia, Todd Bosanac, Chaim Putterman, Deborah Webb, Jay S. Fine, Samantha A. Chalmers, Elizabeth Glynn, Leal Herlitz, Josephine Pelletier
Lupus nephritis is a common disease manifestation of SLE, in which immune complex deposition and macrophage activation are important contributors to disease pathogenesis. Bruton's tyrosine kinase (BTK) plays an important role in both B cell and Fcgam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bb9ead8f88d8eaf92e5a48b14ef6ea
https://europepmc.org/articles/PMC6384222/
https://europepmc.org/articles/PMC6384222/
Autor:
Jaan A. Pesti, Ahmed F. Abdel-Magid, Rajappa Vaidyanathan, Yi-Yin Ku, Michael D. Wendt, Robert Dugger, Bryan Li, Paul Richardson, Rémy Angelaud, Steve Staben, Timothy Heffron, Andreas Schuster, Frédéric St-Jean, Stefan G. Koenig, Thomas H. Pillow, Andreas Stumpf, Daniel Sutherlin, Christoph M. Dehnhardt, Neil F. Langille, Daniel B. Horne, David C. Blakemore, Thomas Brandt, Craig Knight, Sarah E. Skerratt, Christian Harcken, Joshuaine Grant, Hossein Razavi, Maurice A. Marsini, Frederic G. Buono, Jon C. Lorenz, Jonathan T. Reeves, James J. Crawford, Haiming Zhang, David W. Piotrowski, Emma L. McInturff, Andrew J. Peat, Shiping Xie