A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer’s disease

Autor: Annett Boeddrich, Christian Haenig, Nancy Neuendorf, Eric Blanc, Andranik Ivanov, Marieluise Kirchner, Philipp Schleumann, Irem Bayraktaroğlu, Matthias Richter, Christine Mirjam Molenda, Anje Sporbert, Martina Zenkner, Sigrid Schnoegl, Christin Suenkel, Luisa-Sophie Schneider, Agnieszka Rybak-Wolf, Bianca Kochnowsky, Lauren M. Byrne, Edward J. Wild, Jørgen E. Nielsen, Gunnar Dittmar, Oliver Peters, Dieter Beule, Erich E. Wanker

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-32 (2023)

Abstract Background Alzheimer’s disease (AD) is characterized by the intra- and extracellular accumulation of amyloid-β (Aβ) peptides. How Aβ aggregates perturb the proteome in brains of patients and AD transgenic mouse models, remains largely u

Externí odkaz: https://doaj.org/article/84f66523eef540e7aa35e8b03a0fbf0e

The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice

Autor: Nancy Neuendorf, Miguel A. Andrade-Navarro, Nicole Groenke, Erich E. Wanker, David P. Wolfer, Eric Blanc, Sigrid Schnoegl, Wilfried Nietfeld, Christian Erck, Elisabetta Vannoni, Dieter Beule, Christian Haenig, Beate Friedrich, Annett Boeddrich, Julius Tachu Babila, Henrik Martens, Manuela Jacob, Alexander Buntru, Jochen C. Meier, Thomas Wiglenda, Maarten Loos, Lisa Diez, Matthew R. Huska

Self-propagating amyloid-β (Aβ) aggregates or seeds possibly drive pathogenesis of Alzheimer's disease (AD). Small molecules targeting such structures might act therapeutically in vivo. Here, a fluorescence polarization assay was established that e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a69b46279601dc0db4c44c0dadefcc
https://www.zora.uzh.ch/id/eprint/159044/

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

Autor: Yacine Bounab, Gillian P. Bates, Ralf P. Friedrich, David Fournier, Josef Priller, Miguel A. Andrade-Navarro, Konrad Klockmeier, Christian Haenig, Matthias E. Futschik, Franziska Hesse, Sean Patrick Riechers, Erich E. Wanker, Stephan J. Sigrist, Sargon Yigit, Martin Stroedicke, Nadine U. Strempel, Michael R. Hayden, Rona K. Graham, Sigrid Schnoegl, Annett Boeddrich, Shuang Li, Jenny Russ, Thomas Wiglenda, Cecilia Nicoletti, Gautam Chaurasia

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b6410b3bf5fa81355c1008e6a41ee2
https://hdl.handle.net/10400.1/11700

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.

Autor: Boeddrich, Annett¹ (AUTHOR), Haenig, Christian¹ (AUTHOR), Neuendorf, Nancy¹ (AUTHOR), Blanc, Eric² (AUTHOR), Ivanov, Andranik² (AUTHOR), Kirchner, Marieluise³ (AUTHOR), Schleumann, Philipp¹ (AUTHOR), Bayraktaroğlu, Irem¹ (AUTHOR), Richter, Matthias⁴ (AUTHOR), Molenda, Christine Mirjam⁴ (AUTHOR), Sporbert, Anje⁴ (AUTHOR), Zenkner, Martina¹ (AUTHOR), Schnoegl, Sigrid¹ (AUTHOR), Suenkel, Christin⁵ (AUTHOR), Schneider, Luisa-Sophie⁶ (AUTHOR), Rybak-Wolf, Agnieszka⁵ (AUTHOR), Kochnowsky, Bianca⁶ (AUTHOR), Byrne, Lauren M.⁷ (AUTHOR), Wild, Edward J.^7,8 (AUTHOR), Nielsen, Jørgen E.⁹ (AUTHOR)

Publikováno v: Genome Medicine. 7/20/2023, Vol. 15 Issue 1, p1-32. 32p.

GENETIC INTERACTIONS WITH PRENATAL SOCIAL ENVIRONMENT: EFFECTS ON ACADEMIC AND BEHAVIORAL OUTCOMES.

Autor: Conley, Dalton, Rauscher, Emily

Publikováno v: New This Week; 5/24/2010, Special section p1-34, 36p