Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Christian, Anthon"'
Autor:
Xiaoguang Pan, Kunli Qu, Hao Yuan, Xi Xiang, Christian Anthon, Liubov Pashkova, Xue Liang, Peng Han, Giulia I. Corsi, Fengping Xu, Ping Liu, Jiayan Zhong, Yan Zhou, Tao Ma, Hui Jiang, Junnian Liu, Jian Wang, Niels Jessen, Lars Bolund, Huanming Yang, Xun Xu, George M. Church, Jan Gorodkin, Lin Lin, Yonglun Luo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Thorough evaluation of CRISPR RNA-guided nucleases off-targets in cells is required for advancing gene therapies. Here the authors report SURRO-seq for the simultaneous investigation of thousands of off-target sites for therapeutic RNA-guided nucleas
Externí odkaz:
https://doaj.org/article/faf474f6db144a9c827ec4b0d699e6f7
Autor:
Giulia I. Corsi, Veerendra P. Gadekar, Henriette Haukedal, Nadezhda T. Doncheva, Christian Anthon, Sheetal Ambardar, Dasaradhi Palakodeti, Poul Hyttel, Kristine Freude, Stefan E. Seemann, Jan Gorodkin
Publikováno v:
Neurobiology of Disease, Vol 178, Iss , Pp 105980- (2023)
Alzheimer's disease (AD) is a progressive and irreversible brain disorder, which can occur either sporadically, due to a complex combination of environmental, genetic, and epigenetic factors, or because of rare genetic variants in specific genes (fam
Externí odkaz:
https://doaj.org/article/ee81fe4b9b794196a8c7ff4609458c32
Autor:
Reza Yarani, Oana Palasca, Nadezhda T. Doncheva, Christian Anthon, Bartosz Pilecki, Cecilie A. S. Svane, Aashiq H. Mirza, Thomas Litman, Uffe Holmskov, Claus H. Bang-Berthelsen, Mogens Vilien, Lars J. Jensen, Jan Gorodkin, Flemming Pociot
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Background: Ulcerative colitis (UC) is a disorder with unknown etiology, and animal models play an essential role in studying its molecular pathophysiology. Here, we aim to identify common conserved pathological UC-related gene expression signatures
Externí odkaz:
https://doaj.org/article/715c5209dfe143fea179b0e716c6022a
Autor:
Adrian S. Geissler, Line D. Poulsen, Nadezhda T. Doncheva, Christian Anthon, Stefan E. Seemann, Enrique González-Tortuero, Anne Breüner, Lars J. Jensen, Carsten Hjort, Jeppe Vinther, Jan Gorodkin
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The production of the alpha-amylase (AMY) enzyme in Bacillus subtilis at a high rate leads to the accumulation of unfolded AMY, which causes secretion stress. The over-expression of the PrsA chaperone aids enzyme folding and reduces stress. To identi
Externí odkaz:
https://doaj.org/article/a60d2c584eda4fc5adb17a7740bf7e63
Autor:
Xi Xiang, Giulia I. Corsi, Christian Anthon, Kunli Qu, Xiaoguang Pan, Xue Liang, Peng Han, Zhanying Dong, Lijun Liu, Jiayan Zhong, Tao Ma, Jinbao Wang, Xiuqing Zhang, Hui Jiang, Fengping Xu, Xin Liu, Xun Xu, Jian Wang, Huanming Yang, Lars Bolund, George M. Church, Lin Lin, Jan Gorodkin, Yonglun Luo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
High-quality gRNA activity data is needed for accurate on-target efficiency predictions. Here the authors generate activity data for over 10,000 gRNA and build a deep learning model CRISPRon for improved performance predictions.
Externí odkaz:
https://doaj.org/article/d2630a00271e4fa5a1f663c1d03d658b
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Circular RNAs (circRNAs) are covalently closed circular non-coding RNAs. Due to their structure, circRNAs are more stable and have longer half-lives than linear RNAs making them good candidates for disease biomarkers. Despite the scientific
Externí odkaz:
https://doaj.org/article/c8f442d289464ac8acabedd39d7fec54
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Recent experimental efforts of CRISPR-Cas9 systems have shown that off-target binding and cleavage are a concern for the system and that this is highly dependent on the selected guide RNA (gRNA) design. Computational predictions o
Externí odkaz:
https://doaj.org/article/db0da2dc3e364612a8fb5241fb9530f7
Autor:
Mette Juul Jacobsen, Jakob H. Havgaard, Christian Anthon, Caroline M. Junker Mentzel, Susanna Cirera, Poula Maltha Krogh, Sachin Pundhir, Peter Karlskov-Mortensen, Camilla S. Bruun, Philippe Lesnik, Maryse Guerin, Jan Gorodkin, Claus B. Jørgensen, Merete Fredholm, Romain Barrès
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Reprogramming of adipocyte function in obesity is implicated in metabolic disorders like type 2 diabetes. Here, we used the pig, an animal model sharing many physiological and pathophysiological similarities with humans, to perform in-depth epigenomi
Externí odkaz:
https://doaj.org/article/3694cf17ee5f4b5aa9d134ca74b090ee
Publikováno v:
Bioinformatics and Biology Insights, Vol 2015, Iss Suppl. 4, Pp 49-58 (2016)
Externí odkaz:
https://doaj.org/article/2a5df9f0899043eba721d514b3b31566
Autor:
Adrian Sven Geissler, Annaleigh Ohrt Fehler, Line Dahl Poulsen, Enrique González-Tortuero, Thomas Beuchert Kallehauge, Ferhat Alkan, Christian Anthon, Stefan Ernst Seemann, Michael Dolberg Rasmussen, Anne Breüner, Carsten Hjort, Jeppe Vinther, Jan Gorodkin
Publikováno v:
Geissler, A S, Fehler, A O, Poulsen, L D, Gonzalez-Tortuero, E, Kallehauge, T B, Alkan, F, Anthon, C, Seemann, S E, Rasmussen, M D, Breuener, A, Hjort, C, Vinther, J & Gorodkin, J 2023, ' CRISPRi screen for enhancing heterologous alpha-amylase yield in Bacillus subtilis ', Journal of Industrial Microbiology and Biotechnology, vol. 50, no. 1, kuac028 . https://doi.org/10.1093/jimb/kuac028
Yield improvements in cell factories can potentially be obtained by fine-tuning the regulatory mechanisms for gene candidates. In pursuit of such candidates, we performed RNA-sequencing of two α-amylase producing Bacillus strains and predict hundred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ab4bc4d4013dd5d0ff231de64602d9
https://doi.org/10.1093/jimb/kuac028
https://doi.org/10.1093/jimb/kuac028