Zobrazeno 1 - 10
of 412
pro vyhledávání: '"Christian, Aalkjaer"'
Publikováno v:
Experimental Physiology, Vol 108, Iss 10, Pp 1233-1234 (2023)
Externí odkaz:
https://doaj.org/article/f8f7211ab7d94902871f5f703a1093ae
Autor:
Salomé Rognant, Violetta V. Kravtsova, Elena V. Bouzinova, Elizaveta V. Melnikova, Igor I. Krivoi, Sandrine V. Pierre, Christian Aalkjaer, Thomas A. Jepps, Vladimir V. Matchkov
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background: Several local Ca2+ events are characterized in smooth muscle cells. We have previously shown that an inhibitor of the Na,K-ATPase, ouabain induces spatially restricted intracellular Ca2+ transients near the plasma membrane, and suggested
Externí odkaz:
https://doaj.org/article/a56547571fdf460383871f5d844faae0
Autor:
Christian Staehr, Palle Duun Rohde, Nikolaj Thure Krarup, Steffen Ringgaard, Christoffer Laustsen, Jacob Johnsen, Rikke Nielsen, Hans Christian Beck, Jens Preben Morth, Karin Lykke‐Hartmann, Nichlas Riise Jespersen, Denis Abramochkin, Mette Nyegaard, Hans Erik Bøtker, Christian Aalkjaer, Vladimir Matchkov
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 7 (2022)
Background Mutations in ATP1A2 gene encoding the Na,K‐ATPase α2 isoform are associated with familial hemiplegic migraine type 2. Migraine with aura is a known risk factor for heart disease. The Na,K‐ATPase is important for cardiac function, but
Externí odkaz:
https://doaj.org/article/82227bc414f6440f9965cdb15cfd02ed
Autor:
Vladimir V. Matchkov, Henrik Black Joergensen, Dmitrii Kamaev, Andreas Hoegh Jensen, Hans Christian Beck, Boris V. Skryabin, Christian Aalkjaer
Publikováno v:
Physiological Reports, Vol 8, Iss 22, Pp n/a-n/a (2020)
Abstract A Ca2+‐activated Cl− channel protein, ANO1, is expressed in vascular smooth muscle cells where Cl− current is thought to potentiate contraction by contributing to membrane depolarization. However, there is an inconsistency between prev
Externí odkaz:
https://doaj.org/article/3e4d7138a8154e6db823e29a760b0017
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Autor:
Kasper Thorsen, Vibeke S. Dam, Kasper Kjaer-Sorensen, Lisbeth N. Pedersen, V. Arvydas Skeberdis, Jonas Jurevičius, Rimantas Treinys, Ida M. B. S. Petersen, Morten S. Nielsen, Claus Oxvig, J. Preben Morth, Vladimir V. Matchkov, Christian Aalkjær, Henning Bundgaard, Henrik K. Jensen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Mutations in potassium and calcium channel genes have been associated with cardiac arrhythmias. Here, Jensen et al. show that an anion transporter chloride-bicarbonate exchanger AE3 is also responsible for the genetically-induced mechanism of cardiac
Externí odkaz:
https://doaj.org/article/97e6cbf2131e4127b04d04f0aede118d
Autor:
Simon Comerma-Steffensen, Attila Kun, Elise R. Hedegaard, Susie Mogensen, Christian Aalkjaer, Ralf Köhler, Birgitte Mønster Christensen, Ulf Simonsen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Modulation of endothelial calcium-activated K+ channels has been proposed as an approach to restore arterial endothelial cell function in disease. We hypothesized that small-conductance calcium-activated K+ channels (KCa2.3 or SK3) contribut
Externí odkaz:
https://doaj.org/article/dab7db72e22f40a78a98f135e3d4f24c
Autor:
Thomas A. Jepps, Ylva Hellsten, Jennifer van der Horst, Thomas Ehlers, Christian Aalkjaer, Lasse A. Gliemann, Sophie A. Moller
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cardiovascular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::427b3db5a15534a6f3c0b9ce94b35828
https://doi.org/10.1124/jpet.122.173430
https://doi.org/10.1124/jpet.122.173430
Autor:
Morten Krogh Christiansen, Kasper Kjær-Sørensen, Natacha C. Clavsen, Sven Dittmann, Maja Fuhlendorff Jensen, Halvor Østerby Guldbrandsen, Lisbeth Nørum Pedersen, Rikke Hasle Sørensen, Dorte Launholt Lildballe, Klara Müller, Patrick Müller, Kira Vogel, Boris Rudic, Martin Borggrefe, Claus Oxvig, Christian Aalkjær, Eric Schulze-Bahr, Vladimir Matchkov, Henning Bundgaard, Henrik Kjærulf Jensen
Publikováno v:
Christiansen, M K, Kjær-Sørensen, K, Clavsen, N C, Dittmann, S, Jensen, M F, Guldbrandsen, H Ø, Pedersen, L N, Sørensen, R H, Lildballe, D L, Müller, K, Müller, P, Vogel, K, Rudic, B, Borggrefe, M, Oxvig, C, Aalkjær, C, Schulze-Bahr, E, Matchkov, V, Bundgaard, H & Jensen, H K 2023, ' Genetic analysis identifies the SLC4A3 anion exchanger as a major gene for short QT syndrome ', Heart Rhythm . https://doi.org/10.1016/j.hrthm.2023.02.010
BACKGROUND: A variant in the SLC4A3 anion exchanger has been identified as a novel cause of short QT syndrome (SQTS), but the clinical importance of SLC4A3as a cause of SQTS or sudden cardiac death remains unknown.OBJECTIVE: The purpose of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f454713583fe811efeb1db561427be
https://doi.org/10.1016/j.hrthm.2023.02.010
https://doi.org/10.1016/j.hrthm.2023.02.010
Publikováno v:
Petersen, L, Aalkjaer, C & Bek, T 2022, ' Vasomotion in Retinal Arterioles Is Modified by Exercise and Flicker Stimulation ', Investigative ophthalmology & visual science, vol. 63, no. 13, 7 . https://doi.org/10.1167/iovs.63.13.7
Purpose: Vasomotion is spontaneous oscillations in the diameter of resistance vessels with derived effects on blood flow, and it has been proposed that disturbances in vasomotion may be involved in retinal vascular disease. The purpose of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc995f939eb24b76f173397376e91ad
https://pure.au.dk/portal/da/publications/vasomotion-in-retinal-arterioles-is-modified-by-exercise-and-flicker-stimulation(636c5ef5-855f-4f57-a4ec-0171576331ec).html
https://pure.au.dk/portal/da/publications/vasomotion-in-retinal-arterioles-is-modified-by-exercise-and-flicker-stimulation(636c5ef5-855f-4f57-a4ec-0171576331ec).html
Autor:
Thomas S. Ehlers, Jennifer van der Horst, Sophie Møller, Peter K. Piil, Lasse Gliemann, Christian Aalkjær, Thomas A. Jepps, Ylva Hellsten
Publikováno v:
Ehlers, T S, van der Horst, J, Møller, S, Piil, P K, Gliemann, L, Aalkjær, C, Jepps, T A & Hellsten, Y 2023, ' Colchicine enhances β adrenoceptor-mediated vasodilation in men with essential hypertension ', British Journal of Clinical Pharmacology, vol. 89, no. 7, pp. 2179-2189 . https://doi.org/10.1111/bcp.15688
Aims: The aim of this study is to examine whether colchicine improves β adrenoceptor-mediated vasodilation in humans by conducting a double-blinded, placebo-controlled intervention study. Colchicine treatment has known beneficial effects on cardiova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb045921001591a7c7007fb1d3f67b6
https://doi.org/10.22541/au.166385167.75118030/v1
https://doi.org/10.22541/au.166385167.75118030/v1