Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Christiaan P J De Kock"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1011468 (2024)
Neurons in the cerebral cortex receive thousands of synaptic inputs per second from thousands of presynaptic neurons. How the dendritic location of inputs, their timing, strength, and presynaptic origin, in conjunction with complex dendritic physiolo
Externí odkaz:
https://doaj.org/article/ce3cff420a6047cf8d74850cc27144c2
Autor:
Stan L. W. Driessens, Anna A. Galakhova, Djai B. Heyer, Isabel J. Pieterse, René Wilbers, Eline J. Mertens, Femke Waleboer, Tim S. Heistek, Loet Coenen, Julia R. Meijer, Sander Idema, Philip C. de Witt Hamer, David P. Noske, Christiaan P. J. de Kock, Brian R. Lee, Kimberly Smith, Jonathan T. Ting, Ed S. Lein, Huibert D. Mansvelder, Natalia A. Goriounova
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract GWAS have identified numerous genes associated with human cognition but their cell type expression profiles in the human brain are unknown. These genes overlap with human accelerated regions (HARs) implicated in human brain evolution and mig
Externí odkaz:
https://doaj.org/article/50832097a77b45fca91162348467e082
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 15 (2023)
Information transfer between principal neurons in neocortex occurs through (glutamatergic) synaptic transmission. In this focussed review, we provide a detailed overview on the strength of synaptic neurotransmission between pairs of excitatory neuron
Externí odkaz:
https://doaj.org/article/762a4867924848c48df5583221a79016
Autor:
Matthijs N. Oude Lohuis, Jean L. Pie, Pietro Marchesi, Jorrit S. Montijn, Christiaan P. J. de Kock, Cyriel M. A. Pennartz, Umberto Olcese
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How primary sensory cortices contribute to decision making remains poorly understood. Here the authors report that increasing task demands extend the temporal window in which the primary visual cortex is required for detecting identical stimuli.
Externí odkaz:
https://doaj.org/article/4b69656efb054dd6bfc59378dedc6068
Autor:
Christiaan P. J. de Kock, Jean Pie, Anton W. Pieneman, Rebecca A. Mease, Arco Bast, Jason M. Guest, Marcel Oberlaender, Huibert D. Mansvelder, Bert Sakmann
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
In order to investigate the information encoded by spiking activity in different neuronal cell types in the primary somatosensory cortex, de Kock et al performed electrophysiological recordings in untrained rats. They demonstrated that an increase in
Externí odkaz:
https://doaj.org/article/545cc6b7f83a4daf9de820113342a7e0
Autor:
Joshua Obermayer, Antonio Luchicchi, Tim S. Heistek, Sybren F. de Kloet, Huub Terra, Bastiaan Bruinsma, Ouissame Mnie-Filali, Christian Kortleven, Anna A. Galakhova, Ayoub J. Khalil, Tim Kroon, Allert J. Jonker, Roel de Haan, Wilma D. J. van de Berg, Natalia A. Goriounova, Christiaan P. J. de Kock, Tommy Pattij, Huibert D. Mansvelder
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
VIP interneurons have been shown to disinhibit pyramidal neurons by inhibiting other interneuron types. Here, the authors report that ChAT-VIP subtype of interneurons directly excite pyramidal neurons in multiple layers via fast cholinergic neurotran
Externí odkaz:
https://doaj.org/article/59339fd0ec524e8d8a59a8fece53b4cb
Autor:
Matthijs N. Oude Lohuis, Jean L. Pie, Pietro Marchesi, Jorrit S. Montijn, Christiaan P. J. de Kock, Cyriel M. A. Pennartz, Umberto Olcese
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/852be8979df1479692b887079a6459eb
Autor:
Sarah Hunt, Yoni Leibner, Eline J Mertens, Natalí Barros-Zulaica, Lida Kanari, Tim S Heistek, Mahesh M Karnani, Romy Aardse, René Wilbers, Djai B Heyer, Natalia A Goriounova, Matthijs B Verhoog, Guilherme Testa-Silva, Joshua Obermayer, Tamara Versluis, Ruth Benavides-Piccione, Philip de Witt-Hamer, Sander Idema, David P Noske, Johannes C Baayen, Ed S Lein, Javier DeFelipe, Henry Markram, Huibert D Mansvelder, Felix Schürmann, Idan Segev, Christiaan P J de Kock
Publikováno v:
Hunt, S, Leibner, Y, Mertens, E J, Barros-Zulaica, N, Kanari, L, Heistek, T S, Karnani, M M, Aardse, R, Wilbers, R, Heyer, D B, Goriounova, N A, Verhoog, M B, Testa-Silva, G, Obermayer, J, Versluis, T, Benavides-Piccione, R, de Witt-Hamer, P, Idema, S, Noske, D P, Baayen, J C, Lein, E S, DeFelipe, J, Markram, H, Mansvelder, H D, Schürmann, F, Segev, I & de Kock, C P J 2023, ' Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex ', Cerebral cortex (New York, N.Y. : 1991), vol. 33, no. 6, pp. 2857-2878 . https://doi.org/10.1093/cercor/bhac246
Cerebral cortex (New York, N.Y. : 1991), 33(6), 2857-2878. Oxford University Press
Hunt, S, Leibner, Y, Mertens, E J, Barros-Zulaica, N, Kanari, L, Heistek, T S, Karnani, M M, Aardse, R, Wilbers, R, Heyer, D B, Goriounova, N A, Verhoog, M B, Testa-Silva, G, Obermayer, J, Versluis, T, Benavides-Piccione, R, de Witt-Hamer, P, Idema, S, Noske, D P, Baayen, J C, Lein, E S, DeFelipe, J, Markram, H, Mansvelder, H D, Schürmann, F, Segev, I & de Kock, C P J 2023, ' Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex ', Cerebral cortex (New York, N.Y. : 1991), vol. 33, no. 6, pp. 2857-2878 . https://doi.org/10.1093/cercor/bhac246, https://doi.org/10.1093/cercor/bhac246
Cerebral cortex (New York, N.Y. : 1991), 33(6), 2857-2878. Oxford University press
Cerebral cortex (New York, N.Y. : 1991), 33(6), 2857-2878. Oxford University Press
Hunt, S, Leibner, Y, Mertens, E J, Barros-Zulaica, N, Kanari, L, Heistek, T S, Karnani, M M, Aardse, R, Wilbers, R, Heyer, D B, Goriounova, N A, Verhoog, M B, Testa-Silva, G, Obermayer, J, Versluis, T, Benavides-Piccione, R, de Witt-Hamer, P, Idema, S, Noske, D P, Baayen, J C, Lein, E S, DeFelipe, J, Markram, H, Mansvelder, H D, Schürmann, F, Segev, I & de Kock, C P J 2023, ' Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex ', Cerebral cortex (New York, N.Y. : 1991), vol. 33, no. 6, pp. 2857-2878 . https://doi.org/10.1093/cercor/bhac246, https://doi.org/10.1093/cercor/bhac246
Cerebral cortex (New York, N.Y. : 1991), 33(6), 2857-2878. Oxford University press
Synaptic transmission constitutes the primary mode of communication between neurons. It is extensively studied in rodent but not human neocortex. We characterized synaptic transmission between pyramidal neurons in layers 2 and 3 using neurosurgically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91045113000d5b810c2551415662a60a
https://doi.org/10.1093/cercor/bhac246
https://doi.org/10.1093/cercor/bhac246
Autor:
Matthijs B. Verhoog, Joshua Obermayer, Christian A. Kortleven, René Wilbers, Jordi Wester, Johannes C. Baayen, Christiaan P. J. De Kock, Rhiannon M. Meredith, Huibert D. Mansvelder
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nicotinic acetylcholine receptors (nAChRs) are differentially expressed across cortical layers, yet it is unclear whether they show layer-specific effects on synaptic plasticity in the prefrontal cortex. Here, the authors compare nAChRs across L6 and
Externí odkaz:
https://doaj.org/article/dfb3fee0fe6243589a8dcbee3f84b457
Autor:
Joshua Obermayer, Antonio Luchicchi, Tim S. Heistek, Sybren F. de Kloet, Huub Terra, Bastiaan Bruinsma, Ouissame Mnie-Filali, Christian Kortleven, Anna A. Galakhova, Ayoub J. Khalil, Tim Kroon, Allert J. Jonker, Roel de Haan, Wilma D. J. van de Berg, Natalia A. Goriounova, Christiaan P. J. de Kock, Tommy Pattij, Huibert D. Mansvelder
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/a04239147e064305a9366bd3092f352a