Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christiaan J M Saris"'
Autor:
Francesca Diane M Liu, Elisabeth E Kenngott, Micha F Schröter, Anja Kühl, Silke Jennrich, Ralf Watzlawick, Ute Hoffmann, Thorsten Wolff, Stephen Norley, Alexander Scheffold, Jason S Stumhofer, Christiaan J M Saris, Jan M Schwab, Christopher A Hunter, Gudrun F Debes, Alf Hamann
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004110 (2014)
Infection with influenza virus can result in massive pulmonary infiltration and potentially fatal immunopathology. Understanding the endogenous mechanisms that control immunopathology could provide a key to novel adjunct therapies for this disease. H
Externí odkaz:
https://doaj.org/article/f46c7abf103043808e7e70a88af3992e
Autor:
Emily Gwyer Findlay, Ana Villegas-Mendez, J. Brian de Souza, Eleanor M. Riley, Lisa M Grady, Noelle O'Regan, Christiaan J. M. Saris, Kevin N. Couper
Publikováno v:
Infection and Immunity. 82:10-20
Interleukin-27 (IL-27) is known to control primary CD4 + T cell responses during a variety of different infections, but its role in regulating memory CD4 + T responses has not been investigated in any model. In this study, we have examined the functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed2fbe063d501286589bda591341537
https://doi.org/10.1128/iai.01091-13
https://doi.org/10.1128/iai.01091-13
Autor:
Tetsuaki Hirase, Yoshiyuki Miyazaki, Hiromitsu Hara, Koichi Node, Hiroki Yoshida, Noriko Ide, Hirokazu Fujimoto, Ai Nishimoto-Hazuku, Christiaan J. M. Saris
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H420-H429
Chronic inflammation in arterial wall that is driven by immune cells and cytokines plays pivotal roles in the development of atherosclerosis. Interleukin 27 (IL-27) is a member of the IL-12 family of cytokines that consists of IL-27p28 and Epstein-Ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a6a52f837de1c3805f03a9f6589a23
https://doi.org/10.1152/ajpheart.00198.2013
https://doi.org/10.1152/ajpheart.00198.2013
Autor:
Christiaan J. M. Saris, Guang Xian Zhang, Abdolmohamad Rostami, Melissa Cullimore, Pegah Safabakhsh, Denise C. Fitzgerald, Zoe Fonseca-Kelly
Publikováno v:
The Journal of Immunology. 190:3225-3234
IFN-β, IL-27, and IL-10 have been shown to exert a range of similar immunoregulatory effects in murine and human experimental systems, particularly in Th1- and Th17-mediated models of autoimmune inflammatory disease. In this study we sought to trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58c650a9759ce28b53bdc6fbb8c59aca
https://doi.org/10.4049/jimmunol.1200141
https://doi.org/10.4049/jimmunol.1200141
Autor:
Sibylle von Vietinghoff, Mitchell Kronenberg, Gisen Kim, Christiaan J. M. Saris, Klaus Ley, Ekaterina K. Koltsova, Katheleen M. Lloyd
Publikováno v:
Circulation Research. 111:1274-1285
Rationale: Atherosclerosis is a chronic inflammatory disease of the arterial wall. Several proinflammatory cytokines are known to promote atherosclerosis, but less is known about the physiological role of anti-inflammatory cytokines. Interleukin (IL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918c174821c7b7e5833ab910b393f6c2
https://doi.org/10.1161/circresaha.112.277525
https://doi.org/10.1161/circresaha.112.277525
Autor:
Yoshiyuki Miyazaki, Hirokazu Fujimoto, Hiroki Yoshida, Hiromitsu Hara, Koichi Node, Ai Nishimoto-Hazuku, Christiaan J. M. Saris, Noriko Ide-Iwata, Tetsuaki Hirase
Publikováno v:
The American Journal of Pathology. 179:2327-2336
Inflammation driven by immune cells and pro-inflammatory cytokines is implicated in pancreatic β-cell injury, leading to the development of diabetes mellitus. IL-27, a cytokine consisting of IL-27p28 and Epstein-Barr virus-induced gene 3 (EBI3), bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a83db5d22d2b203f27cf5f86f1a0e36
https://doi.org/10.1016/j.ajpath.2011.08.001
https://doi.org/10.1016/j.ajpath.2011.08.001
Publikováno v:
International Immunology. 23:129-137
Mechanisms regulating intestinal T-cell accumulation during inflammation have considerable therapeutic value. In this study, LPS increased Staphylococcus aureus enterotoxin A-specific T cells in the gut through induction of IL-12 family members. Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141a12c68066cc737f453aeacdf50016
https://doi.org/10.1093/intimm/dxq464
https://doi.org/10.1093/intimm/dxq464
Autor:
Yi Chen, Michael Jones, Daniel J. Cua, Michael P. Cancro, Steven D. Levin, William J. Quinn, Stefan Rose-John, Christiaan J. M. Saris, Radhika Goenka, Elia D. Tait, Nancy Hosken, Björn Spudy, Simon Arnett Jones, Ceri Alan Fielding, Jason S. Stumhofer, Joachim Grötzinger, Christopher A. Hunter, M. Merle Elloso, Aisling C. O’Hara
Publikováno v:
Nature immunology
The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c0c93cf8e2a10536dbe4e2b0313089
https://doi.org/10.1038/ni.1957
https://doi.org/10.1038/ni.1957
Autor:
J. Brian de Souza, Emily Gwyer Findlay, Jason S. Stumhofer, Kevin N. Couper, Julius C. R. Hafalla, Christopher A. Hunter, Christiaan J. M. Saris, Eleanor M. Riley, Rachel Greig
Publikováno v:
The Journal of Immunology. 185:2482-2492
Successful resolution of malaria infection requires induction of proinflammatory immune responses that facilitate parasite clearance; however, failure to regulate this inflammation leads to immune-mediated pathology. The pathways that maintain this i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8ba3d6de77cab008a15f35fd5255c5
https://doi.org/10.4049/jimmunol.0904019
https://doi.org/10.4049/jimmunol.0904019
Autor:
Jeff D. Reagan, Shamin Summer, Yuhua Yang, Jenny Ying-Lin Lu, Christiaan J. M. Saris, John Whoriskey, Xiaosu Wu
Publikováno v:
Pharmacology. 86:1-5
We report that the asthma drugs cromolyn disodium and nedocromil sodium are potent G-protein-coupled receptor 35 (GPR35) agonists. We utilized calcium flux and inositol phosphate accumulation assays to examine the pharmacology of these asthma drugs o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0e04967067ca13a28c4420ced0c3fd
https://doi.org/10.1159/000314164
https://doi.org/10.1159/000314164