Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christiaan F. M. Huffels"'
Autor:
Astrid T. van der Geest, Channa E. Jakobs, Tijana Ljubikj, Christiaan F. M. Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H. Rutten, Marthe Kaal, Maria M. Zwartkruis, Mireia Carcolé, Ewout J. N. Groen, Elly M. Hol, Onur Basak, Adrian M. Isaacs, Henk-Jan Westeneng, Leonard H. van den Berg, Jan H. Veldink, Domino K. Schlegel, R. Jeroen Pasterkamp
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-31 (2024)
Abstract A hexanucleotide repeat expansion (HRE) in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Human brain imaging and experimental studies indicate early changes in brain struct
Externí odkaz:
https://doaj.org/article/081ca424a8b945aa9f02a6c9589c4317
Autor:
Jeroen P. H. Verharen, Johannes W. de Jong, Theresia J. M. Roelofs, Christiaan F. M. Huffels, Ruud van Zessen, Mieneke C. M. Luijendijk, Ralph Hamelink, Ingo Willuhn, Hanneke E. M. den Ouden, Geoffrey van der Plasse, Roger A. H. Adan, Louk J. M. J. Vanderschuren
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Aberrant increased dopaminergic function results in impaired value-based decision making. Here the authors report pathway-specific effects of VTA activation on distinct aspects of flexible value-based decisions in rats.
Externí odkaz:
https://doaj.org/article/31622733c1f8444ca230c79f49f730a9
Autor:
Christiaan F M, Huffels, Roland E, van Dijk, Henk, Karst, Frank J, Meye, Elly M, Hol, Jinte, Middeldorp
Publikováno v:
Journal of Alzheimer's Disease. 89:283-297
Background: Aging is characterized by systemic alterations and forms an important risk factor for Alzheimer’s disease (AD). Recently, it has been indicated that blood-borne factors present in the systemic milieu contribute to the aging process. Exp
Publikováno v:
Neurochemical Research. 48:1026-1046
Alzheimer’s disease (AD) causes the majority of dementia cases worldwide. Early pathological hallmarks include the accumulation of amyloid-ß (Aß) and activation of both astrocytes and microglia. Neurons form the building blocks of the central ner
Publikováno v:
Journal of Neuroscience Research, 100(6), 1281-1295. Wiley-Liss Inc.
Astrocytes are critical for healthy brain function. In Alzheimer’s disease, astrocytes become reactive, which affects their signaling properties. Here, we measured spontaneous calcium transients ex vivo in hippocampal astrocytes in brain slices con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cde8e2dca9931593167b2d4f869a73d
https://dare.uva.nl/personal/pure/en/publications/calcium-signaling-in-individual-appps1-mouse-dentate-gyrus-astrocytes-increases-ex-vivo-with-a-pathology-and-age-without-affecting-astrocyte-network-activity(b6911b36-2cc7-4bac-b836-ab30b0604dcf).html
https://dare.uva.nl/personal/pure/en/publications/calcium-signaling-in-individual-appps1-mouse-dentate-gyrus-astrocytes-increases-ex-vivo-with-a-pathology-and-age-without-affecting-astrocyte-network-activity(b6911b36-2cc7-4bac-b836-ab30b0604dcf).html
Autor:
Christiaan F. M. Huffels, Lana M. Osborn, Lianne A. Hulshof, Lieneke Kooijman, Lukas Henning, Christian Steinhäuser, Elly M. Hol
Publikováno v:
Glia. 70
Autor:
Christiaan F. M. Huffels, Lana M. Osborn, Lianne A. Hulshof, Lieneke Kooijman, Lukas Henning, Christian Steinhäuser, Elly M. Hol
Publikováno v:
Glia. 70(4)
Alzheimer pathology is accompanied by astrogliosis. Reactive astrocytes surrounding amyloid plaques may directly affect neuronal communication, and one of the mechanisms by which astrocytes impact neuronal function is by affecting K
Autor:
Lianne A. Hulshof, Nelda Antonovaite, Elly M. Hol, Davide Iannuzzi, Christiaan F. M. Huffels, Wytse J. Wadman
Publikováno v:
Journal of the Mechanical Behavior of Biomedical Materials, 122:104697. Elsevier BV
Antonovaite, N, Hulshof, L A, Huffels, C F M, Hol, E M, Wadman, W J & Iannuzzi, D 2021, ' Mechanical alterations of the hippocampus in the APP/PS1 Alzheimer's disease mouse model ', Journal of the Mechanical Behavior of Biomedical Materials, vol. 122, 104697 . https://doi.org/10.1016/j.jmbbm.2021.104697
Antonovaite, N, Hulshof, L A, Huffels, C F M, Hol, E M, Wadman, W J & Iannuzzi, D 2021, ' Mechanical alterations of the hippocampus in the APP/PS1 Alzheimer's disease mouse model ', Journal of the Mechanical Behavior of Biomedical Materials, vol. 122, 104697 . https://doi.org/10.1016/j.jmbbm.2021.104697
There is increasing evidence of altered tissue mechanics in neurodegeneration. However, due to difficulties in mechanical testing procedures and the complexity of the brain, there is still little consensus on the role of mechanics in the onset and pr