Antibody Correlates of Protection for COVID-19 Convalescent Plasma Associated with Reduced Outpatient Hospitalizations

Autor: Han-Sol Park, Caelan Barranta, Anna Yin, John S. Lee, Christopher A. Caputo, Maggie Li, Steve Yoon, Ioannis Sitaras, Anne Jedlicka, Yolanda Eby, Malathi Ram, Reinaldo E. Fernandez, Owen R. Baker, Aarthi G. Shenoy, Giselle S. Mosnaim, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C. Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. McBee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Bryan Lau, Stephan Ehrhardt, Sheriza N. Baksh, Janna R. Shapiro, Jiangda Ou, Thomas J. Gniadek, Patrizio Caturegli, Jinke Wu, Nelson Ndahiro, Michael J. Betenbaugh, Alyssa Ziman, Daniel F. Hanley, Arturo Casadevall, Shmuel Shoham, Evan M. Bloch, Kelly A. Gebo, Aaron A.R. Tobian, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, David J. Sullivan

Publikováno v: medRxiv

SARS-CoV-2 antibody levels associated with reduced hospitalization risk remain undefined. Our outpatient COVID-19 convalescent plasma (CCP), placebo-controlled trial observed SARS-CoV-2 antibody levels decreasing 22-fold from matched donor units into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124d32fa90320c1ef7c7c5ee968c932a
https://europepmc.org/articles/PMC10153328/

Randomized Controlled Trial of Early Outpatient COVID-19 Treatment with High-Titer Convalescent Plasma

Autor: David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Evan M. Bloch, Bryan Lau, Aarthi G. Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C. Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, E. Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. McBee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A.R. Tobian, Daniel F. Hanley

Publikováno v: medRxiv

BACKGROUNDThe efficacy of polyclonal high titer convalescent plasma to prevent serious complications of COVID-19 in outpatients with recent onset of illness is uncertain.METHODSThis multicenter, double-blind randomized controlled trial compared the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60a0b0a1d17871ffa6da31d8996ec5c
https://doi.org/10.1101/2021.12.10.21267485

HeartWare Ventricular Assist Device Implantation for Pediatric Heart Failure-A Single Center Approach

Autor: John D. Coulson, William Ravekes, Emily E. Brown, Kristen Nelson McMillan, Elizabeth A. Hunt, Rajeev Wadia, Christi E. Marshall, Luca A. Vricella, Diane Alejo, Mayuri Alvarez-Machado, Narutoshi Hibino

Publikováno v: Artificial Organs. 43:21-29

While pediatric HeartWare HVAD application has increased, determining candidacy and timing for initiation of pediatric VAD support has remained a challenge. We present our experience with a systematic approach to HVAD implantation as a bridge to pedi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2076903ceda7c9e43d617eb2f5e5196a
https://doi.org/10.1111/aor.13344

The epidemiology of bacterial culture-positive and septic transfusion reactions at a large tertiary academic center: 2009 to 2016

Autor: Evan M. Bloch, Lorraine Blagg, Lisa Shifflett, Paul M. Ness, Karen C. Carroll, Christi E. Marshall, Eric A. Gehrie, J. S. Boyd, Aaron A.R. Tobian, Sean M. Erony

Publikováno v: Transfusion. 58:1933-1939

Background Bacterial contamination and associated septic transfusion reactions (STRs) remain the leading infectious risk to the blood supply. We sought to characterize the risk and clinical presentation of blood culture-positive transfusion reactions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::314994760a64be45db0f4f45d511ff1b
https://doi.org/10.1111/trf.14789

Isohemagglutinin titering performed on an automated solid-phase and hemagglutinin-based analyzer is comparable to results obtained by manual gel testing

Autor: Niraj M. Desai, Eric A. Gehrie, Evan M. Bloch, Paul M. Ness, Christi E. Marshall, Aaron A.R. Tobian, Amy E. DeZern, Daniel C. Brennan, Heather Smetana, Rivcah Davis, Douglas E. Gladstone, Robert L. Kruse, Angela Roots, Kimberly Lally

Publikováno v: TransfusionREFERENCES. 60(3)

Background Isohemagglutinins (anti-A and anti-B) mediate hemolytic transfusion reactions, antibody-mediated rejection of solid-organ transplants, and delayed engraftment after stem cell transplant. However, quantification of isohemagglutinins is ofte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f6d6046db2d202554f8f20ba60f11d
https://pubmed.ncbi.nlm.nih.gov/31957889