Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Christer von Bahr"'
Autor:
Elisabeth Törnqvist, Folke Sjöqvist, Lars-Olof Hensjö, Paul Hjemdahl, Lars L. Gustafsson, Susan Sjöberg, Margaretha Julander, Björn Wettermark, Christer von Bahr, Daniel Schmidt, Rolf Tryselius, Jan Hasselström, Eva Andersén-Karlsson, Ingrid Jägre, Ulf Bergman, Bo Ringertz, Carl-Olav Stiller, Brian Godman, Sigurd Vitols
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 108:224-233
The aim was to present and evaluate the impact of a comprehensive strategy over 10 years to select, communicate and achieve adherence to essential drug recommendations (EDR) in ambulatory care in a metropolitan healthcare region. EDRs were issued and
Autor:
Hans Pettersson, Erik Eliasson, Michael Lundberg, Björn Wettermark, Christer von Bahr, Buster Mannheimer
Publikováno v:
British Journal of Clinical Pharmacology. 69:411-417
The study aimed to investigate the clinical adherence to drug label recommendations on important drug-drug interactions (DDIs). Dispensing data on drug combinations involving selective serotonin reuptake inhibitor (SSRI) antidepressants could help to
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:337-346
The use of lidocaine as an oral antiarrhythmic drug is limited by its rapid disposition in the liver. In accordance with this we found that the drug was completely extracted during one passage through the perfused rat liver. The drug binds to rat liv
Autor:
Peter Moldéus, Robert Grundin, Christer von Bahr, Karl Olov Borg, Sten Orrenius, Inger Skånberg
Publikováno v:
Acta Pharmacologica et Toxicologica. 35:242-260
The highly lipid soluble β-receptor blocking drug alprenolol interacts with high affinity with rat liver microsomal cytochrome P-450, is rapidly metabolized in the liver and exhibits a marked liver “first pass elimination” (FPE) in the rat. It t
Autor:
Olof Borgåa, Christer von Bahr
Publikováno v:
Acta Pharmacologica et Toxicologica. 29:359-374
The isolated perfused rat liver was used in order to study the metabolism of the tricyclic antidepressant drug, desmethylimipramine (DMI), which is metabolized by oxidation and subsequent conjugation. DMI labelled with tritium in a position in which
Autor:
Inger Skånberg, Christer von Bahr, Karl Olof Borg, Erik Fellenius, Peter Moldéus, Kurt‐Jürgen Hoffmann
Publikováno v:
Acta Pharmacologica et Toxicologica. 44:28-35
Kinetic studies of the metabolism of alprenolol were performed with isolated microsomes from the rat, guinea-pig, dog and man at an initial substrate concentration of 0.17--150 micrometer. In all species the rate of aromatic hydroxylation reached a p
Publikováno v:
Acta Pharmacologica et Toxicologica. 41:39-48
When the local anaesthetic drug lidocaine is added to liver microsomes biphasic type I spectral change titration curves can be observed. A high-affinity and a low-affinity phase is observed. In the present study we have found that microsomes from fem
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:49-52
We have incubated the local anaesthetic drug lidocaine with microsomes from human adult livers. The metabolites deethylated lidocaine (MEGX) and aromatically hydroxylated lidocaine (3-hydroxylidocaine) were isolated by high performance liquid chromat
Publikováno v:
European Journal of Clinical Pharmacology. 64:1209-1214
To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIs). One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interview
Autor:
Christer von Bahr, Johanna Ulfvarson, Marie Reilly, Regina Wredling, Bengt Kjellman, Johanna Adami
Publikováno v:
European Journal of Clinical Pharmacology. 59:735-740
The aim of the investigation was to study the effects of withdrawing selective serotonin reuptake inhibitor (SSRI) drugs in nursing home patients, who had no documented diagnosis or symptoms of depression. The setting of the study was in 11 nursing h