Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Christer Tannergren"'
Autor:
Jamie D. Patient, Hadi Hajiali, Kate Harris, Bertil Abrahamsson, Christer Tannergren, Lisa J. White, Amir M. Ghaemmaghami, Philip M. Williams, Clive J. Roberts, Felicity R. A. J. Rose
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Advances in drug research not only depend on high throughput screening to evaluate large numbers of lead compounds but also on the development of in vitro models which can simulate human tissues in terms of drug permeability and functions. Potential
Externí odkaz:
https://doaj.org/article/7dc3f38233024ba8a0515838ba90a5ce
Autor:
Christer Tannergren, Harshad Jadhav, Emma Eckernäs, Jonas Fagerberg, Patrick Augustijns, Erik Sjögren
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 186:144-159
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61623d914eaff75487743744e24b14e
https://doi.org/10.1016/j.ejpb.2023.03.013
https://doi.org/10.1016/j.ejpb.2023.03.013
Autor:
Emma Eckernäs, Christer Tannergren
Publikováno v:
Molecular Pharmaceutics
Colon absorption is a key determinant for the successful development of modified-release (MR) formulations, and the risk that colon absorption may limit the in vivo performance of an MR product can be assessed early by various in vitro tests or by pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1b7b60cc956619abb5f0579764af53
https://doi.org/10.1021/acs.molpharmaceut.0c01201
https://doi.org/10.1021/acs.molpharmaceut.0c01201
Autor:
Erik Sjögren, James Butler, Vidula Kolhatkar, Xavier Pepin, Lynne S. Taylor, Andrew Babiskin, Sandra Suarez-Sharp, Paul Seo, Jennifer B. Dressman, Christer Tannergren, André Dallmann, Xinyuan Zhang, Poonam Delvadia, Edmund Kostewicz, Yang Zhao, Amitava Mitra, Filippos Kesisoglou, Mirko Koziolek, Neil Parrott
Publikováno v:
Journal of Pharmaceutical Sciences. 110:567-583
This workshop report summarizes the proceedings of Day 1 of a three-day workshop on “Current State and Future Expectations of Translational Modeling Strategies to Support Drug Product Development, Manufacturing Changes and Controls”. Physiologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d0f759414a16121ec56c04e1405fb4
https://doi.org/10.1016/j.xphs.2020.09.021
https://doi.org/10.1016/j.xphs.2020.09.021
Autor:
Alex Mattinson, David Lindley, Helena Engman, Manthena V.S. Varma, Anh-Thu Nguyen-Trung, Binfeng Xia, Xavier Pepin, Linette Ruston, Wei Zhu, Bill van Osdol, Celine Ollier, David Good, Jonathan Brown, Laurent Boulu, Talia Flanagan, Olivier Nicolas, Staffan Berg, Shanoo Budhdeo, Aarti Patel, Jan Bevernage, Handan He, Sweta Modi, Richard Barker, Claire Jackson, Christer Tannergren, Xiojun Ren, Stephane Beilles, J. Matthew Wood, Johanna Laru, Pierre Daublain, Sara Carlert, Louis Henrion, Jean-Flaubert Nguefack, Gunilla Hanisch, Eva Karlsson, Wen Lin, Shruthi Vaidhyanathan, Robert Carr, Fan Wu, Jin Zhang, Amais Ahmad, James M. Mullin, Sari Pappinen, Andrea Moir, Ke Szeto, Christine Xu, Claire Patterson, David B. Turner, Guillaume Louit, Yuya Wang, Tycho Heimbach, Richard Lloyd, Frans Franek, Masoud Jamei, Christophe Tistaert, Bertil Abrahamsson, Kerstin Julia Schäfer, Leon Aarons, Shriram M. Pathak, Adam S. Darwich, Suet Wong, Dónal Murphy, Amin Rostami-Hodjegan, Timo Korjamo, Helena Thörn, Kartrin Schmid, Michael B. Bolger, Johanna Tuunainen, Mai Anh Nguyen
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 156:50-63
Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation characteristics and their interplay with gastrointestinal physiology and biology. Physiological-based pharmacokinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bca05a74d852f38ad03c52e9e4fba40
https://doi.org/10.1016/j.ejpb.2020.08.006
https://doi.org/10.1016/j.ejpb.2020.08.006
Autor:
David Dahlgren, Markus Sjöblom, Christer Tannergren, Anders Lundqvist, Hans Lennernäs, Karsten Peters, Erik Sjögren, Carl Roos
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 142:31-37
The rat single-pass intestinal perfusion (SPIP) model is commonly used to investigate gastrointestinal physiology and membrane drug transport. The SPIP model can be used with the intestinal segment inside or outside the abdomen. The rats can also be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5619b94322d962ff1cb9bc80578edce
https://doi.org/10.1016/j.ejpb.2019.06.011
https://doi.org/10.1016/j.ejpb.2019.06.011
Autor:
Christer Tannergren, Anders Lundqvist, David Dahlgren, Markus Sjöblom, Hans Lennernäs, Erik Sjögren, Carl Roos
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 132:19-28
The relevance of the rat single-pass intestinal perfusion model for investigating in vivo time-dependent effects of absorption-modifying excipients (AMEs) is not fully established. Therefore, the dynamic effect and recovery of the intestinal mucosa w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bacd8a2a86bbda8fa12f33060ef1cc
https://doi.org/10.1016/j.ejpb.2018.09.001
https://doi.org/10.1016/j.ejpb.2018.09.001
Autor:
Richard Lloyd, Leon Aarons, Mark McAllister, Amitava Mitra, Chester Costales, Timo Korjamo, Maria Hammarberg, Helena Thörn, Carole Shardlow, Jussi Malkki, Adam S. Darwich, Tycho Heimbach, Achiel Van Peer, James M. Mullin, Jennifer B. Dressman, Johanna Laru, Dónal Murphy, Handan He, Jian Lin, Irina Mishenzon, Ke X. Szeto, Mei Wong, Peter Langguth, Bertil Abrahamsson, Carolin Hoft, Fan Wu, Mohammed Yasin, Olivier Nicolas, Manthena V.S. Varma, Alison Margolskee, Christer Tannergren, Edmund Kostewicz, Yan Pang, Shriram M. Pathak, Johanna Tuunainen, Constanze Hilgendorf, Sari Pappinen, Viera Lukacova, Charles J. Rotter, Jan Bevernage, Sweta Modi, Sergej Ramusovic, Simone Hansmann, Mai Anh Nguyen, Amin Rostami-Hodjegan, Eva Huehn, Michael B. Bolger, Jonathan Brown, Loic Laplanche, Christine Xu, Eva Karlsson, Sara Carlert, Pernilla Johansson, Florent Mazuir, Jeike Biewenga, Xavier Pepin, Hans Lennernäs, Aleksandra Galetin
Publikováno v:
Margolskee, A, Darwich, A, Aarons, L, Galetin, A, Rostami-Hochaghan, A, Carlert, S, Hammarberg, M, Hilgendorf, C, Johansson, P, Karlsson, E, Murphy, D, Tannergren, C, Thorn, H, Yasin, M, Mazuir, F, Nicolas, O, Ramusovic, S, Xu, C, Pathak, S, Korjamo, T, Laru, J, Malkki, J, Pappinen, S, Tuunainen, J, Dressman, J, Hansmann, S, Kostewicz, E, He, H, Heimbach, T, Wu, F, Hoft, C, Laplanche, L, Pang, Y, Bolger, M B, Huehn, E, Lukacova, V, Mullin, J M, Szeto, K X, Costales, C, Lin, J, McAllister, M, Modi, S, Rotter, C, Varma, M, Wong, M, Mitra, A, Bevernage, J, Biewenga, J, Van Peer, A, Lloyd, R, Shardlow, C, Langguth, P, Mishenzon, I, Nguyen, M A, Brown, J, Lennernas, H & Abrahamsson, B 2016, ' IMI – Oral Biopharmaceutics Tools project – Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results ', European Journal of Pharmaceutical Sciences . https://doi.org/10.1016/j.ejps.2016.10.036
Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6089d0117fb2833be9097c7fcd93759e
https://doi.org/10.1016/j.ejps.2016.10.036
https://doi.org/10.1016/j.ejps.2016.10.036
Autor:
Franziska Graf, Wolfgang Mück, Dominique Swerts, Kerstin J. Frank, Dorina van der Mey, Joanne Bennett, Marta Venczel, Thomas Müller, Uwe Muenster, Hans Lennernäs, Florent Mazuir, Jan Bevernage, Mei Wong, Mark McAllister, Stéphane Beilles, Loic Laplanche, Alison Margolskee, Stefania Beato, Lieve Adriaenssen, Loeckie de Zwart, Jonas Angstenberger, Xavier Pepin, Anh-Thu Nguyen-Trung, Alexander Marker, Amin Rostami-Hodjegan, P. Zane, Céline Ollier, An Van Den Bergh, Adam S. Darwich, Shriram M. Pathak, Dónal Murphy, Markus Kolhmann, Pankaj Daga, Susanne Greschat-Schade, Michael B. Bolger, Achiel Van Peer, Christer Tannergren, Priscilla Brun, Mohammed Yasin, Bertil Abrahamsson, Sara Carlert, Richard Lloyd, Christophe Tistaert, Leon Aarons, Petra Loos, Xavier Boulenc, Pascale Vicat
Publikováno v:
Margolskee, A, Darwich, A, Pepin, X, Pathak, S M, Bolger et al, M B, Aarons, L, Rostami-Hochaghan, A, Angstenberger, J, Graf, F, Laplanche, L, Muller, T, Carlert, S, Daga, P, Murphy, D, Tannergren, C, Yasin, M, Greschat-Schade, S, Muck, W, Muenster, U, van der Mey, D, Frank, K, Lloyd, R, Adriaenssen, L, Bevernage, J, De Zwart, L, Swerts, D, Tistaert, C, Van Den Bergh, A, Van Peer, A, Beato, S, Nguyen-Trung, A-T, Bennett, J, McAllister, M, Wong, M, Zane, P, Ollier, C, Vicat, P, Kolhmann, M, Marker, A, Brun, P, Mazuir, F, Beilles, S, Venczel, M, Boulenc, X, Loos, P, Lennernas, H & Abrahamsson, B 2016, ' IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds ', European Journal of Pharmaceutical Sciences . https://doi.org/10.1016/j.ejps.2016.09.027
Predicting oral bioavailability (Foral) is of importance for estimating systemic exposure of orally administered drugs. Physiologically-based pharmacokinetic (PBPK) modelling and simulation have been applied extensively in biopharmaceutics recently.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb52ebb9ed35fea70aa7eb44eca0076
https://doi.org/10.1016/j.ejps.2016.09.027
https://doi.org/10.1016/j.ejps.2016.09.027
Autor:
Kate Harris, Christer Tannergren, Philip M. Williams, Hadi Hajiali, Jamie Patient, Felicity R. A. J. Rose, Bertil Abrahamsson, Clive J. Roberts, Lisa J. White, Amir M. Ghaemmaghami
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology, Vol 10 (2019)
Advances in drug research not only depend on high throughput screening to evaluate large numbers of lead compounds but also on the development of in vitro models which can simulate human tissues in terms of drug permeability and functions. Potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f8464989aa8ef349656e742dcdeb03
http://europepmc.org/articles/PMC6524416
http://europepmc.org/articles/PMC6524416