Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Christer S Ejsing"'
Autor:
Bianca M Esch, Sergej Limar, André Bogdanowski, Christos Gournas, Tushar More, Celine Sundag, Stefan Walter, Jürgen J Heinisch, Christer S Ejsing, Bruno André, Florian Fröhlich
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008745 (2020)
Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoy
Externí odkaz:
https://doaj.org/article/f15f92c4af7244398daf7ac4bcf75b8e
Autor:
Josch K Pauling, Martin Hermansson, Jürgen Hartler, Klaus Christiansen, Sandra F Gallego, Bing Peng, Robert Ahrends, Christer S Ejsing
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188394 (2017)
Advances in mass spectrometry-based lipidomics have in recent years prompted efforts to standardize the annotation of the vast number of lipid molecules that can be detected in biological systems. These efforts have focused on cataloguing, naming and
Externí odkaz:
https://doaj.org/article/116b0c47a2a54f21b3dcbca12c694c4e
Autor:
Huajin Wang, Michel Becuwe, Benjamin E Housden, Chandramohan Chitraju, Ashley J Porras, Morven M Graham, Xinran N Liu, Abdou Rachid Thiam, David B Savage, Anil K Agarwal, Abhimanyu Garg, Maria-Jesus Olarte, Qingqing Lin, Florian Fröhlich, Hans Kristian Hannibal-Bach, Srigokul Upadhyayula, Norbert Perrimon, Tomas Kirchhausen, Christer S Ejsing, Tobias C Walther, Robert V Farese Jr
Publikováno v:
eLife, Vol 5 (2016)
How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood. Using Drosophila and human cells, we show here that seipin, an ER protein implicated in LD biology, mediates a discrete step in LD formation—the conversion o
Externí odkaz:
https://doaj.org/article/883e847c4c0c4cafacec7a73841c1ae8
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145831 (2016)
Ceramide is synthesized in yeast by two redundant acyl-CoA dependent synthases, Lag1 and Lac1. In lag1∆ lac1∆ cells, free fatty acids and sphingoid bases are elevated, and ceramides are produced through the redundant alkaline ceramidases Ypc1 and
Externí odkaz:
https://doaj.org/article/1988e9e70c824d738d333ea716728094
Autor:
Florian Fröhlich, Constance Petit, Nora Kory, Romain Christiano, Hans-Kristian Hannibal-Bach, Morven Graham, Xinran Liu, Christer S Ejsing, Robert V Farese Jr, Tobias C Walther
Publikováno v:
eLife, Vol 4 (2015)
Sphingolipids are abundant membrane components and important signaling molecules in eukaryotic cells. Their levels and localization are tightly regulated. However, the mechanisms underlying this regulation remain largely unknown. In this study, we id
Externí odkaz:
https://doaj.org/article/0230e65b8c7b4312b88ff014183e4da8
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144817 (2015)
Long-chain bases (LCBs) are both intermediates in sphingolipid metabolism and potent signaling molecules that control cellular processes. To understand how regulation of sphingolipid metabolism and levels of individual LCB species impinge upon physio
Externí odkaz:
https://doaj.org/article/6fee27c82bf94bd5a00d1caab5335051
Autor:
Ombretta Foresti, Annamaria Ruggiano, Hans K Hannibal-Bach, Christer S Ejsing, Pedro Carvalho
Publikováno v:
eLife, Vol 2 (2013)
Sterol homeostasis is essential for the function of cellular membranes and requires feedback inhibition of HMGR, a rate-limiting enzyme of the mevalonate pathway. As HMGR acts at the beginning of the pathway, its regulation affects the synthesis of s
Externí odkaz:
https://doaj.org/article/75c34d82ec6c42e88f63c8417bb5a661
Autor:
Mai-Britt Mosbech, Rikke Kruse, Eva Bang Harvald, Anne Sofie Braun Olsen, Sandra Fernandez Gallego, Hans Kristian Hannibal-Bach, Christer S Ejsing, Nils J Færgeman
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70087 (2013)
Ceramide and its metabolites constitute a diverse group of lipids, which play important roles as structural entities of biological membranes as well as regulators of cellular growth, differentiation, and development. The C. elegans genome comprises t
Externí odkaz:
https://doaj.org/article/123aa8c456f54949a4d4d820ae3406a6
Autor:
Peter Husen, Kirill Tarasov, Maciej Katafiasz, Elena Sokol, Johannes Vogt, Jan Baumgart, Robert Nitsch, Kim Ekroos, Christer S Ejsing
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79736 (2013)
Global lipidomics analysis across large sample sizes produces high-content datasets that require dedicated software tools supporting lipid identification and quantification, efficient data management and lipidome visualization. Here we present a nove
Externí odkaz:
https://doaj.org/article/2875d08594fa440a9aac72465e73e8ef
Autor:
Lars Kuerschner, Doris Richter, Hans Kristian Hannibal-Bach, Anne Gaebler, Andrej Shevchenko, Christer S Ejsing, Christoph Thiele
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31342 (2012)
Ether lipids are ubiquitous constituents of cellular membranes with no discrete cell biological function assigned yet. Using fluorescent polyene-ether lipids we analyzed their intracellular distribution in living cells by microscopy. Mitochondria and
Externí odkaz:
https://doaj.org/article/f9db9821ef1d40f6903a035a58fd357f