Zobrazeno 1 - 10 of 217 pro vyhledávání: '"Christer Owman"'
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Akademický článek
Fluorescent leukotriene B4: potential applications
Autor: Alan Sabirsh, Anders Wetterholm, Jesper Bristulf, Hakon Leffler, Jesper Z. Haeggström, Christer Owman
Publikováno v: Journal of Lipid Research, Vol 46, Iss 6, Pp 1339-1346 (2005)
Leukotriene B4 (LTB4) is a potent lipid mediator of inflammation that acts primarily via a seven-transmembrane-spanning, G-protein-coupled receptor denoted BLT1. Here, we describe the synthesis and characterization of fluorescent analogs of LTB4 that
Externí odkaz: https://doaj.org/article/34688e58d34849408d808b5139cfdf5b
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Perivascular cholinesterase and morphological blood-brain barrier function
Autor: Jan Erik Hardebo, Christer Owman
Publikováno v: Acta Neurologica Scandinavica. 70:438-442
– Little is known about the function of cholinesterase activity present in the walls of cerebral microvessels. It has been shown that systemically administered physostigmine, a cholinesterase inhibitor that penetrates the blood-brain barrier, cause
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b374eab0dbf5a077313f256c06c0f24
https://doi.org/10.1111/j.1600-0404.1984.tb00849.x
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8
Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes
Autor: Rannar Sillard, Åke Boketoft, Åke Norberg, Björn Olde, Stefan R. Hansson, Niclas E. Nilsson, L. M. Fredrik Leeb-Lundberg, Christer Owman, Jesper Bristulf, Knut Kotarsky
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 318:619-628
Here, the ligand binding, activation, and tissue distribution of the orphan G protein-coupled receptor (GPCR) GPR92 were studied. GPR92 binds and is activated by compounds based on the lysophosphatidic acid (LPA) backbone. The binding of LPA to GPR92
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263d4cbc2295c2b551f5a3428b6e42af
https://doi.org/10.1124/jpet.105.098848
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Residues from Transmembrane Helices 3 and 5 Participate in Leukotriene B4 Binding to BLT1
Autor: Robert P. Bywater, Christer Owman, Jesper Bristulf, Alan Sabirsh, Jesper Z Haeggström
Publikováno v: Biochemistry. 45:5733-5744
Leukotrienes are inflammatory mediators that bind to seven transmembrane, G-protein-coupled receptors (GPCRs). Here we examine residues from transmembrane helices 3 and 5 of the leukotriene B4 (LTB4) receptor BLT1 to elucidate how these residues are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3b7cb08b738f51357d9a7f27cd6eb0
https://doi.org/10.1021/bi060076t
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Non-specific effects of leukotriene synthesis inhibitors on HeLa cell physiology
Autor: Ulf O. Karlsson, Jesper Bristulf, Christer Owman, Alan Sabirsh, Jesper Z. Haeggström
Publikováno v: Prostaglandins, Leukotrienes and Essential Fatty Acids. 73:431-440
We examined the effects of various leukotriene synthesis inhibitors on calcium signalling in HeLa cells, before and after transfection with BLT(1). All of the inhibitors studied were found to reduce increases in intracellular calcium concentration in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ddc8b7e0e86d5137e8b2ef78ac777c
https://doi.org/10.1016/j.plefa.2005.08.004
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