Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Christer Nyström"'
Autor:
M Ehrnebo, Jack Spira, Tommy Lewander, Tobias Bäckström, Dag Nyholm, Christer Nyström, C G Trolin, G Panagiotidis, Sten-Magnus Aquilonius
Publikováno v:
Acta Neurologica Scandinavica. 127:124-132
OBJECTIVES:An oral dispersible microtablet formulation of levodopa/carbidopa 5/1.25 mg (LC-5) was developed for individualized repeated dosing. The aim was to compare pharmacokinetic profiles of LC-5 and levodopa/carbidopa/entacapone (LCE).MATERIALS
Autor:
Cecilia Gomes-Trolin, Tommy Lewander, Dag Nyholm, Sten-Magnus Aquilonius, Tobias Bäckström, Georgios Panagiotidis, Christer Nyström, Mats Ehrnebo
Publikováno v:
Clinical Neuropharmacology. 35:111-117
Objectives To compare bioavailability and pharmacokinetics of single doses of 3 different levodopa formulations given orally in healthy volunteers. Two marketed formulations, standard levodopa/carbidopa, 100/25 mg (LC-100), and dispersible levodopa/b
Autor:
Christer Nyström, Sten-Magnus Aquilonius, L.-E. Hansson, Lennart Paalzow, K. Johansson, Dag Nilsson
Publikováno v:
Acta Neurologica Scandinavica. 97:175-183
Objective - To evaluate the effects of continuous duodenal infusion of levodopa over time on the disabling fluctuations in motor performance in advanced parkinsonian patients. It has earlier been demonstrated that these fluctuations can be reduced by
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 67:370-376
The aim of this study was to investigate whether mucoadhesive interactive mixtures can be created using carrier particles in a size range appropriate for nasal administration, i.e. 10-50 microm. We also used theoretical models to investigate if homog
Publikováno v:
Journal of Drug Delivery Science and Technology. 17:267-271
The objective was to investigate the transport of dihydroergotamine (DHE) across porcine nasal respiratory and olfactory mucosa and to evaluate the absorption enhancing effect of a novel dry pow ...
Autor:
Hans Lennernäs, M Holmberg, Bo Lennernäs, Christer Nyström, Thomas Hedner, Susanne Bredenberg
Publikováno v:
British Journal of Clinical Pharmacology. 59:249-253
It is estimated that two-thirds of cancer patients will at some point during their illness experience breakthrough pain. In this study, the pharmacokinetics of a novel sublingual dosage form of fentanyl developed for breakthrough pain was evaluated.E
Autor:
Susanne Bredenberg, Bo Lennernäs, Christer Nyström, Hans Lennernäs, Margareta Duberg, Anders Pettersson, Marie Westerberg
Publikováno v:
European Journal of Pharmaceutical Sciences. 20:327-334
Oromucosal delivery of drugs promotes rapid absorption and high bioavailability, with subsequent almost immediate onset of pharmacological effect. However, many oromucosal delivery systems are compromised by the possibility of the patient swallowing
Autor:
Cecilia Gomes-Trolin, Tina W. Knutson, Sten-Magnus Aquilonius, Dag Nyholm, Hans Lennernäs, Håkan Askmark, Christer Nyström
Publikováno v:
Clinical Neuropharmacology. 26:156-163
Continuous duodenal infusion of carbidopa/levodopa has been shown to control motor fluctuations in advanced Parkinson's disease (PD). The authors compared the pharmacokinetics of levodopa and 3-O-methyldopa in patients with advanced PD after administ
Publikováno v:
Drug Development and Industrial Pharmacy. 29:1095-1107
The particle properties and solid-state characteristics of two celluloses, Avicel PH101 and cellulose obtained from the alga Cladophora sp., were evaluated and related to the compaction behavior and the properties of the tablets made from them. The s
Autor:
Christer Nyström, Sofia Mattsson
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 52:237-247
This study investigated the effect of binders with different deformability characteristics on the pore structure of tablets composed of binary mixtures. The pore structure was evaluated using mercury porosimetry. The pore size distribution in tablets