Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes

Autor: Bonnefond Amélie, Witte Daniel, Jørgensen Torben, Sandbæk Anneli, Christensen Cramer, Brandslund Ivan, Nielsen Aneta A, Gjesing Anette P, Froguel Phillippe, Hansen Torben, Pedersen Oluf

Publikováno v: BMC Medical Genetics, Vol 12, Iss 1, p 99 (2011)

Abstract Background Single nucleotide polymorphisms (SNPs) within the gene encoding Hexokinase 1 (HK1) are associated with changes in glycated haemoglobin (HbA1c) levels. Our aim was to investigate the effect of HK1 rs7072268 on measures of glucose-

Externí odkaz: https://doaj.org/article/07441f542bbc42beb36fd2192179260a

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Autor: Kraja, Aldi T. ^{1, 101, ∗}, Liu, Chunyu ^{2, 101}, Fetterman, Jessica L. ^{3, 101}, Graff, Mariaelisa ^{4, 101}, Have, Christian Theil ^{5, 101}, Gu, Charles ^{6, 101}, Yanek, Lisa R. ⁷, Feitosa, Mary F. ¹, Arking, Dan E. ⁸, Chasman, Daniel I. ^{9, 10}, Young, Kristin ⁴, Ligthart, Symen ¹¹, Hill, W. David ¹², Weiss, Stefan ¹³, Luan, Jian’an ¹⁴, Giulianini, Franco ⁹, Li-Gao, Ruifang ¹⁵, Hartwig, Fernando P. ^{16, 17}, Lin, Shiow J. ¹, Wang, Lihua ¹, Richardson, Tom G. ¹⁷, Yao, Jie ¹⁸, Fernandez, Eliana P. ¹¹, Ghanbari, Mohsen ¹¹, Wojczynski, Mary K. ¹, Lee, Wen-Jane ^{19, 20}, Argos, Maria ²¹, Armasu, Sebastian M. ²², Barve, Ruteja A. ²³, Ryan, Kathleen A. ²⁴, An, Ping ¹, Baranski, Thomas J. ²⁵, Bielinski, Suzette J. ²⁶, Bowden, Donald W. ²⁷, Broeckel, Ulrich ²⁸, Christensen, Kaare ²⁹, Chu, Audrey Y. ⁹, Corley, Janie ¹², Cox, Simon R. ¹², Uitterlinden, Andre G. ³⁰, Rivadeneira, Fernando ³⁰, Cropp, Cheryl D. ³¹, Daw, E. Warwick ¹, van Heemst, Diana ³², de las Fuentes, Lisa ³³, Gao, He ³⁴, Tzoulaki, Ioanna ^{34, 35}, Ahluwalia, Tarunveer S. ³⁶, de Mutsert, Renée ¹⁵, Emery, Leslie S. ³⁷, Erzurumluoglu, A. Mesut ³⁸, Perry, James A. ²⁴, Fu, Mao ²⁴, Forouhi, Nita G. ¹⁴, Gu, Zhenglong ³⁹, Hai, Yang ¹⁸, Harris, Sarah E. ⁴⁰, Hemani, Gibran ¹⁷, Hunt, Steven C. ^{41, 42}, Irvin, Marguerite R. ⁴³, Jonsson, Anna E. ⁵, Justice, Anne E. ^{4, 44}, Kerrison, Nicola D. ¹⁴, Larson, Nicholas B. ²⁶, Lin, Keng-Hung ⁴⁵, Love-Gregory, Latisha D. ⁴⁶, Mathias, Rasika A. ^{7, 47}, Lee, Joseph H. ⁴⁸, Nauck, Matthias ⁴⁹, Noordam, Raymond ³², Ong, Ken K. ¹⁴, Pankow, James ⁵⁰, Patki, Amit ⁵¹, Pattie, Alison ¹², Petersmann, Astrid ⁴⁹, Qi, Qibin ⁵², Ribel-Madsen, Rasmus ^{5, 53, 54}, Rohde, Rebecca ⁴, Sandow, Kevin ¹⁸, Schnurr, Theresia M. ⁵, Sofer, Tamar ^{37, 55}, Starr, John M. ^{12, 56}, Taylor, Adele M. ¹², Teumer, Alexander ⁵⁷, Timpson, Nicholas J. ¹⁷, de Haan, Hugoline G. ¹⁵, Wang, Yujie ⁴, Weeke, Peter E. ⁵⁸, Williams, Christine ¹, Wu, Hongsheng ⁵⁹, Yang, Wei ⁶⁰, Zeng, Donglin ⁶¹, Witte, Daniel R. ⁶², Weir, Bruce S. ³⁷, Wareham, Nicholas J. ¹⁴, Vestergaard, Henrik ^{5, 36}, Turner, Stephen T. ⁶³, Torp-Pedersen, Christian ⁶⁴, Stergiakouli, Evie ¹⁷, Sheu, Wayne Huey-Herng ^{65, 66, 67, 68}, Rosendaal, Frits R. ¹⁵, Ikram, M. Arfan ¹¹, Franco, Oscar H. ^{11, 69}, Ridker, Paul M. ^{9, 10}, Perls, Thomas T. ⁷⁰, Pedersen, Oluf ⁵, Nohr, Ellen A. ⁷¹, Newman, Anne B. ⁷², Linneberg, Allan ^{73, 74, 75}, Langenberg, Claudia ¹⁴, Kilpeläinen, Tuomas O. ⁵, Kardia, Sharon L.R. ⁷⁶, Jørgensen, Marit E. ³⁶, Jørgensen, Torben ^{77, 78, 79}, Sørensen, Thorkild I.A. ⁸⁰, Homuth, Georg ¹³, Hansen, Torben ⁵, Goodarzi, Mark O. ⁸¹, Deary, Ian J. ¹², Christensen, Cramer ⁸², Chen, Yii-Der Ida ¹⁸, Chakravarti, Aravinda ⁸³, Brandslund, Ivan ^{84, 85}, Bonnelykke, Klaus ^{86, 87}, Taylor, Kent D. ¹⁸, Wilson, James G. ⁸⁸, Rodriguez, Santiago ¹⁷, Davies, Gail ¹², Horta, Bernardo L. ¹⁶, Thyagarajan, Bharat ⁸⁹, Rao, D.C. ⁶, Grarup, Niels ⁵, Davila-Roman, Victor G. ³³, Hudson, Gavin ⁹⁰, Guo, Xiuqing ¹⁸, Arnett, Donna K. ⁹¹, Hayward, Caroline ⁹², Vaidya, Dhananjay ⁷, Mook-Kanamori, Dennis O. ^{15, 93}, Tiwari, Hemant K. ⁵¹, Levy, Daniel ⁹⁴, Loos, Ruth J.F. ^{95, 96, 97}, Dehghan, Abbas ³⁴, Elliott, Paul ³⁴, Malik, Afshan N. ⁹⁸, Scott, Robert A. ¹⁴, Becker, Diane M. ⁷, de Andrade, Mariza ²², Province, Michael A. ^{1, 102}, Meigs, James B. ^{55, 99, 100, 102}, Rotter, Jerome I. ^{18, 102}, North, Kari E. ^{4, 102, ∗∗}

Publikováno v: In The American Journal of Human Genetics 3 January 2019 104(1):112-138

Rhodopsin in plasma from patients with diabetic retinopathy – development and validation of digital ELISA by Single Molecule Array (Simoa) technology

Autor: Petersen, Eva Rabing Brix ^{a, b, ⁎}, Olsen, Dorte Aalund ^a, Christensen, Henry ^a, Hansen, Søren Berndt ^c, Christensen, Cramer ^d, Brandslund, Ivan ^{a, b}

Publikováno v: In Journal of Immunological Methods July 2017 446:60-69

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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Autor: Mahajan, Anubha, Taliun, Daniel, Thurner, Matthias, Robertson, Neil R, Torres, Jason M, Rayner, N William, Payne, Anthony J, Steinthorsdottir, Valgerdur, Scott, Robert A, Grarup, Niels, Cook, James P, Schmidt, Ellen M, Wuttke, Matthias, Sarnowski, Chloé, Mägi, Reedik, Nano, Jana, Gieger, Christian, Trompet, Stella, Lecoeur, Cécile, Preuss, Michael H, Prins, Bram Peter, Guo, Xiuqing, Bielak, Lawrence F, Below, Jennifer E, Bowden, Donald W, Chambers, John Campbell, Kim, Young Jin, Ng, Maggie C Y, Petty, Lauren E, Sim, Xueling, Zhang, Weihua, Bennett, Amanda J, Bork-Jensen, Jette, Brummett, Chad M, Canouil, Mickaël, Ec Kardt, Kai-Uwe, Fischer, Krista, Kardia, Sharon L R, Kronenberg, Florian, Läll, Kristi, Liu, Ching-Ti, Locke, Adam E, Luan, Jian'an, Ntalla, Ioanna, Nylander, Vibe, Schönherr, Sebastian, Schurmann, Claudia, Yengo, Loïc, Bottinger, Erwin P, Brandslund, Ivan, Christensen, Cramer, Dedoussis, George, Florez, Jose C, Ford, Ian, Franco, Oscar H, Frayling, Timothy M, Giedraitis, Vilmantas, Hackinger, Sophie, Hattersley, Andrew T, Herder, Christian, Ikram, M Arfan, Ingelsson, Martin, Jørgensen, Marit E, Jørgensen, Torben, Kriebel, Jennifer, Kuusisto, Johanna, Ligthart, Symen, Lindgren, Cecilia M, Linneberg, Allan, Lyssenko, Valeriya, Mamakou, Vasiliki, Meitinger, Thomas, Mohlke, Karen L, Morris, Andrew D, Nadkarni, Girish, Pankow, James S, Peters, Annette, Sattar, Naveed, Stančáková, Alena, Strauch, Konstantin, Taylor, Kent D, Thorand, Barbara, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tuomilehto, Jaakko, Witte, Daniel R, Dupuis, Josée, Peyser, Patricia A, Zeggini, Eleftheria, Loos, Ruth J F, Froguel, Philippe, Ingelsson, Erik, Lind, Lars, Groop, Leif, Laakso, Markku, Collins, Francis S, Jukema, J Wouter, Palmer, Colin N A, Grallert, Harald, Metspalu, Andres, Dehghan, Abbas, Köttgen, Anna, Abecasis, Goncalo R, Meigs, James B, Rotter, Jerome I, Marchini, Jonathan, Pedersen, Oluf, Hansen, Torben, Langenberg, Claudia, Wareham, Nicholas J, Stefansson, Kari, Gloyn, Anna L, Morris, Andrew P, Boehnke, Michael, McCarthy, Mark I

Publikováno v: Mahajan, A, Taliun, D, Thurner, M, Robertson, N R, Torres, J M, Rayner, N W, Payne, A J, Steinthorsdottir, V, Scott, R A, Grarup, N, Cook, J P, Schmidt, E M, Wuttke, M, Sarnowski, C, Mägi, R, Nano, J, Gieger, C, Trompet, S, Lecoeur, C, Preuss, M H, Prins, B P, Guo, X, Bielak, L F, Below, J E, Bowden, D W, Chambers, J C, Kim, Y J, Ng, M C Y, Petty, L E, Sim, X, Zhang, W, Bennett, A J, Bork-Jensen, J, Brummett, C M, Canouil, M, Ec Kardt, K-U, Fischer, K, Kardia, S L R, Kronenberg, F, Läll, K, Liu, C-T, Locke, A E, Luan, J, Ntalla, I, Nylander, V, Schönherr, S, Schurmann, C, Yengo, L, Bottinger, E P, Brandslund, I, Christensen, C, Dedoussis, G, Florez, J C, Ford, I, Franco, O H, Frayling, T M, Giedraitis, V, Hackinger, S, Hattersley, A T, Herder, C, Ikram, M A, Ingelsson, M, Jørgensen, M E, Jørgensen, T, Kriebel, J, Kuusisto, J, Ligthart, S, Lindgren, C M, Linneberg, A, Lyssenko, V, Mamakou, V, Meitinger, T, Mohlke, K L, Morris, A D, Nadkarni, G, Pankow, J S, Peters, A, Sattar, N, Stančáková, A, Strauch, K, Taylor, K D, Thorand, B, Thorleifsson, G, Thorsteinsdottir, U, Tuomilehto, J, Witte, D R, Dupuis, J, Peyser, P A, Zeggini, E, Loos, R J F, Froguel, P, Ingelsson, E, Lind, L, Groop, L, Laakso, M, Collins, F S, Jukema, J W, Palmer, C N A, Grallert, H, Metspalu, A, Dehghan, A, Köttgen, A, Abecasis, G R, Meigs, J B, Rotter, J I, Marchini, J, Pedersen, O, Hansen, T, Langenberg, C, Wareham, N J, Stefansson, K, Gloyn, A L, Morris, A P, Boehnke, M & McCarthy, M I 2018, ' Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps ', Nature Genetics, vol. 50, no. 11, pp. 1505-1513 . https://doi.org/10.1038/s41588-018-0241-6

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::4c8292b6070f0d4db60865ff05bcd506
https://pure.au.dk/portal/da/publications/finemapping-of-an-expanded-set-of-type-2-diabetes-loci-to-singlevariant-resolution-using-highdensity-imputation-and-isletspecific-epigenome-maps(a2fda98a-525b-4713-9fb3-6aa4ffd22cb1).html