Enantioselective Synthesis of Sealutomicin C.

Autor: Astle SM; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Guggiari S; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Frost JR; UCB Pharma, 216 Bath Road, Slough, Berkshire SL1 3WE, U.K., Hepburn HB; Vertex Pharmaceuticals, 86-88 Jubilee Avenue Milton Park, Abingdon OX14 4RW, U.K., Klauber DJ; Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, U.K., Christensen KE; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Burton JW; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2024 Jul 03; Vol. 146 (26), pp. 17757-17764. Date of Electronic Publication: 2024 Jun 17.

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation.

Autor: Martínez Duncker Rebolledo E; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Chan D; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada., Christensen KE; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada., Reagan AM; The Jackson Laboratory, Bar Harbor, ME, USA., Howell GR; The Jackson Laboratory, Bar Harbor, ME, USA.; Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA., Rozen R; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Department of Pediatrics, McGill University, Montreal, QC, Canada., Trasler J; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Department of Pediatrics, McGill University, Montreal, QC, Canada.; Department of Pharmacology & Therapeutics, Montreal, QC, Canada.

Publikováno v: Molecular human reproduction [Mol Hum Reprod] 2024 Mar 28; Vol. 30 (4).

Folate Deficiency and/or the Genetic Variant Mthfr ^{677C >T} Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner.

Autor: Leclerc D; Departments of Human Genetics and Pediatrics, McGill University, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Christensen KE; Departments of Human Genetics and Pediatrics, McGill University, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Reagan AM; The Jackson Laboratory, Bar Harbor, ME, USA., Keser V; Departments of Human Genetics and Pediatrics, McGill University, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Luan Y; Departments of Human Genetics and Pediatrics, McGill University, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Malysheva OV; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, USA., Wasek B; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX, USA., Bottiglieri T; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX, USA., Caudill MA; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, USA., Howell GR; The Jackson Laboratory, Bar Harbor, ME, USA., Rozen R; Departments of Human Genetics and Pediatrics, McGill University, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.

Publikováno v: Molecular nutrition & food research [Mol Nutr Food Res] 2024 Mar; Vol. 68 (5), pp. e2300355. Date of Electronic Publication: 2024 Feb 07.

Taming nonclassical carbocations to control small ring reactivity.

Autor: McNamee RE; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Frank N; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Christensen KE; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Duarte F; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Anderson EA; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.

Publikováno v: Science advances [Sci Adv] 2024 Jan 12; Vol. 10 (2), pp. eadj9695. Date of Electronic Publication: 2024 Jan 12.

Stereoselective Alder-Ene Reactions of Bicyclo[1.1.0]butanes: Facile Synthesis of Cyclopropyl- and Aryl-Substituted Cyclobutenes.

Autor: Dasgupta A; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Bhattacharjee S; Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India., Tong Z; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Guin A; Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India., McNamee RE; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Christensen KE; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K., Biju AT; Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India., Anderson EA; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2024 Jan 10; Vol. 146 (1), pp. 1196-1203. Date of Electronic Publication: 2023 Dec 29.