Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christelle Vachoux"'
Autor:
Maud Maillard, Cécile Arellano, Christelle Vachoux, Christine Chevreau, Nicolas J. Cabaton, Frédéric Pont, Nathalie Saint-Laurent, Thierry Lafont, Etienne Chatelut, Fabienne Thomas
Publikováno v:
Metabolites, Vol 12, Iss 9, p 852 (2022)
Tyrosine kinase inhibitors pazopanib and sunitinib are both used to treat advanced renal cell carcinoma but expose patients to an increased risk of hepatotoxicity. We have previously identified two aldehyde derivatives for pazopanib and sunitinib (P-
Externí odkaz:
https://doaj.org/article/23cee1aa9b5b4384baac2abc171b2232
Autor:
Thi-Mai Anh Dao, Aurélie Waget, Pascale Klopp, Matteo Serino, Christelle Vachoux, Laurent Pechere, Daniel J Drucker, Serge Champion, Sylvain Barthélemy, Yves Barra, Rémy Burcelin, Eric Sérée
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20700 (2011)
Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear. We used a formulation that increases oral bioavailability to assess the mec
Externí odkaz:
https://doaj.org/article/8b96eb10e8834befa95800ee2058fc4c
Autor:
Laurence Venat-Bouvet, Melanie White-Koning, William Jacot, Alicja Puszkiel, Jacques Robert, Etienne Chatelut, Hortense Laharie-Mineur, Thomas Filleron, Valérie Le Morvan, N. Dohollou, Marc Debled, Florence Dalenc, Chantal Bernard-Marty, Alexandre Evrard, Caroline Delmas, Fabienne Thomas, Henri Roché, Jean-Christophe Boyer, Cécile Arellano, Christelle Vachoux
Publikováno v:
Clinical Pharmacology & Therapeutics. 109:1244-1255
Variations in clinical response to tamoxifen (TAM) may be related to polymorphic cytochromes P450 (CYPs) involved in forming its active metabolite endoxifen (ENDO). We developed a population pharmacokinetic (PopPK) model for tamoxifen and six metabol
Autor:
Cécile Arellano, J-C Boyer, Fabienne Thomas, Jacques Robert, Alexandre Evrard, Melanie White-Koning, H. Roche, P Houyau, A Puzskiel, J Dauba, Christelle Vachoux, M Poublanc, Etienne Chatelut, V Le Morvan
Publikováno v:
Cancer Research. 78:P3-12
Supported by a PHRC grant (#09-18-005) Background: The role of CYP2D6 genetic polymorphisms and plasma levels of active metabolites of tamoxifen (TAM) on clinical response and occurrence of side effects remains controversial. We conducted a prospecti
Autor:
Jacques Robert, Alicja Puszkiel, Alexandre Evrard, Etienne Chatelut, Florence Dalenc, Marc Debled, Fabienne Thomas, Caroline Delmas, Laurence Venat-Bouvet, Isabelle Sillet-Bach, Henri Roché, Thomas Filleron, Christelle Vachoux, Etienne Suc, Cécile Arellano, Jean-Christophe Boyer, Valérie Le Morvan, Melanie White-Koning, William Jacot
Publikováno v:
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, American Society for Clinical Pharmacology and Therapeutics, 2019, 106 (3), pp.585-595. ⟨10.1002/cpt.1404⟩
Clinical Pharmacology and Therapeutics, American Society for Clinical Pharmacology and Therapeutics, 2019, 106 (3), pp.585-595. ⟨10.1002/cpt.1404⟩
International audience; In addition to the effect of cytochrome P450 (CYP) 2D6 genetic polymorphisms, the metabolism of tamoxifen may be impacted by other factors with possible consequences on therapeutic outcome (efficacy and toxicity). This analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274f222ae7ab868875ee69e1de41fb8f
https://hal.umontpellier.fr/hal-02420919
https://hal.umontpellier.fr/hal-02420919
Autor:
Mathieu Bergé, Aurélie Waget, Philippe J. Sansonetti, Natalia F. Smirnova, Thierry Sulpice, Rémy Burcelin, Philippe Langella, Luis G. Bermúdez-Humarán, Nina Rautonen, Christelle Vachoux, Jacques Amar, Pascale Klopp, Chantal Chabo, Arthur C. Ouwehand, Sampo J. Lahtinen
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, 2011, 3 (9), pp.559-72. ⟨10.1002/emmm.201100159⟩
EMBO Molecular Medicine; Vol 3
EMBO Molecular Medicine, Wiley Open Access, 2011, 3 (9), pp.559-72. ⟨10.1002/emmm.201100159⟩
EMBO Molecular Medicine 9 (3), 559-572. (2011)
EMBO Molecular Medicine, 2011, 3 (9), pp.559-72. ⟨10.1002/emmm.201100159⟩
EMBO Molecular Medicine; Vol 3
EMBO Molecular Medicine, Wiley Open Access, 2011, 3 (9), pp.559-72. ⟨10.1002/emmm.201100159⟩
EMBO Molecular Medicine 9 (3), 559-572. (2011)
International audience; A fat-enriched diet modifies intestinal microbiota and initiates a low-grade inflammation, insulin resistance and type-2 diabetes. Here, we demonstrate that before the onset of diabetes, after only one week of a high-fat diet
Autor:
Karine Bouyer, Christelle Vachoux, Céline Pomié, Bruno Vergès, Laurence Duvillard, Michael Courtney, Laurent Lagrost, Rémy Burcelin, Céline Garret
Publikováno v:
The Journal of clinical endocrinology and metabolism. 99(7)
Context:Lipopolysaccharides (LPSs) are inflammatory components of the outer membrane of Gram-negative bacteria and, in plasma, are mostly associated with lipoproteins. This association is thought to promote their catabolism while reducing their proin
Autor:
Laurent Pechere, Aurélie Waget, Rémy Burcelin, Yves Barra, Serge Champion, Eric Seree, Matteo Serino, Christelle Vachoux, Thi-Mai Anh Dao, Pascale Klopp, Sylvain Barthélemy, Daniel J. Drucker
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2011, 6 (6), pp.e20700. ⟨10.1371/journal.pone.0020700⟩
Plos One 6 (6), . (2011)
PLoS ONE, 2011, 6 (6), pp.e20700. ⟨10.1371/journal.pone.0020700⟩
PLoS ONE, Vol 6, Iss 6, p e20700 (2011)
PLoS ONE, Public Library of Science, 2011, 6 (6), pp.e20700. ⟨10.1371/journal.pone.0020700⟩
Plos One 6 (6), . (2011)
PLoS ONE, 2011, 6 (6), pp.e20700. ⟨10.1371/journal.pone.0020700⟩
PLoS ONE, Vol 6, Iss 6, p e20700 (2011)
International audience; Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear. We used a formulation that increases oral bioavaila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3585660f67e1f3ba382098cabf4859a
https://www.hal.inserm.fr/inserm-00615233/document
https://www.hal.inserm.fr/inserm-00615233/document
Publikováno v:
Diabetes
Diabetes, 2011, epub ahead of print. ⟨10.2337/db11-0464⟩
Diabetes, American Diabetes Association, 2011, epub ahead of print. ⟨10.2337/db11-0464⟩
Diabetes, 2011, epub ahead of print. ⟨10.2337/db11-0464⟩
Diabetes, American Diabetes Association, 2011, epub ahead of print. ⟨10.2337/db11-0464⟩
OBJECTIVE Glucagon-like peptide 1 (GLP-1) is a gut-brain hormone that regulates food intake, energy metabolism, and cardiovascular functions. In the brain, through a currently unknown molecular mechanism, it simultaneously reduces femoral artery bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a11f999f0cbb2af2820dd5e9e831d36
https://doi.org/10.2337/db11-0464
https://doi.org/10.2337/db11-0464
Autor:
Cécile Arellano, Véronique Dupouy, Georges Houin, John F. Woodley, Alain Bousquet-Mélou, Christelle Vachoux, Peggy Gandia, Guylène Lafforgue, Claude Philibert
Publikováno v:
Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2008, 22 (2), pp.189-201. ⟨10.1111/j.1472-8206.2008.00572.x⟩
Fundamental and Clinical Pharmacology, Wiley, 2008, 22 (2), pp.189-201. ⟨10.1111/j.1472-8206.2008.00572.x⟩
International audience; The beta-lactam antibiotic ampicillin has a relatively poor oral bioavailability in animals and man (30-40%), and its widespread agricultural use in livestock may be contributing to the emergence of antibiotic resistance in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6c40211e1a57b10c2a549dc7b30226
https://hal.archives-ouvertes.fr/hal-00517537
https://hal.archives-ouvertes.fr/hal-00517537