Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christelle Serba"'
Autor:
Roman Lagoutte, Christelle Serba, Daniel Abegg, Dominic G. Hoch, Alexander Adibekian, Nicolas Winssinger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Deoxyelephantopin is a naturally occurring sesquiterpene lactone with known anticancer properties. Here, the authors synthesize deoxyelephantopins and a range of analogues including alkyne-tagged probes, using them to identify its cellular targets.
Externí odkaz:
https://doaj.org/article/1ed6d7b632384db6874986b87650499b
Autor:
Andrea Sala, Chantal Andraud, Fabio A. Facchini, Francesco Peri, Flaviana Di Lorenzo, Thomas R Huser, Olivier Maury, Tung Cheng Wang, Simon Pascal, Lenny Zaffaroni, Florent Cochet, Christelle Serba
Publikováno v:
Bioconjugate Chemistry
Bioconjugate Chemistry, 2019, ⟨10.1021/acs.bioconjchem.9b00044⟩
Bioconjugate Chemistry, American Chemical Society, 2019, ⟨10.1021/acs.bioconjchem.9b00044⟩
Bioconjugate Chemistry, 2019, ⟨10.1021/acs.bioconjchem.9b00044⟩
Bioconjugate Chemistry, American Chemical Society, 2019, ⟨10.1021/acs.bioconjchem.9b00044⟩
Endotoxin (lipooligosaccharide, LOS, and lipopolysaccharide, LPS) is the major molecular component of Gram-negative bacteria outer membrane, and very potent pro-inflammatory substance. Visualizing and tracking the distribution of the circulating endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cae9768fdc43f76222d50fe0a758017
https://pub.uni-bielefeld.de/record/2936627
https://pub.uni-bielefeld.de/record/2936627
Publikováno v:
European Journal of Organic Chemistry
European Journal of Organic Chemistry, Vol. 2016, No 4 (2016) pp. 644-646
European Journal of Organic Chemistry, Vol. 2016, No 4 (2016) pp. 644-646
Sesquiterpenes have been a rich source of bioactive compounds and have inspired innovative methodological developments. Herein we report a rapid and scalable synthesis of a substrate for a 4+3 cycloaddition in order to access the cis-fused bicyclic s
Publikováno v:
Journal of Antibiotics, Vol. 71, No 2 (2018) pp. 248-256
Deoxyelephantopin is a sesquiterpene lactone that was reported to be as effective in the treatment of mammary tumours and lung metastasis as taxol based on a murine orthotopic cancer model. Its germacrene skeleton harbours three Michael acceptors tha
Autor:
Christelle Serba, Nicolas Winssinger
Publikováno v:
European Journal of Organic Chemistry. 2013:4195-4214
This microreview discusses recent efforts in chemical synthesis to design divergent pathways either to access diverse natural products from a common intermediate or to produce diverse libraries of compounds reminiscent of natural products. These effo
Publikováno v:
ChemInform. 47
Sesquiterpenes have been a rich source of bioactive compounds and have inspired innovative methodological developments. Herein we report a rapid and scalable synthesis of a substrate for a 4+3 cycloaddition in order to access the cis-fused bicyclic s
Autor:
José Garcia, Christelle Serba, Nicolas Winssinger, Vincent Duplan, Sofia Barluenga, Gaëlle Valot
Publikováno v:
Angewandte Chemie: International Edition, Vol. 51, No 22 (2012) pp. 5391-5394
Natural selection: An acyclic chain containing an ene-yne-ene motif, in analogy to farnesyl diphosphate, was cyclized to obtain six distinct scaffolds using different transition-metal catalysts (see scheme). Notably, the guaianolide framework was acc
Autor:
Christelle Serba, Mélanie Hoerlé, Nicolas Winssinger, Gaëlle Valot, José Garcia, Sofia Barluenga, Muriel Cuendet, Vincent Duplan
Publikováno v:
Organic and Biomolecular Chemistry, Vol. 12, No 2 (2014) pp. 370-375
A significant portion of bioactive secondary metabolites are endowed with reactive functionalities that can engage in covalent interactions with their target. Sesquiterpene lactones in particular are rich in Michael acceptors that react with cysteine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f405463b66caf5c365143ea33853b383
https://archive-ouverte.unige.ch/unige:32027
https://archive-ouverte.unige.ch/unige:32027
Autor:
Nicolas Winssinger, Christelle Serba
Publikováno v:
ChemInform. 44
This microreview discusses recent efforts in chemical synthesis to design divergent pathways either to access diverse natural products from a common intermediate or to produce diverse libraries of compounds reminiscent of natural products. These effo
Publikováno v:
Chemical Communications, Vol. 49, No 69 (2013) pp. 7608-7610
An expedient and simple protocol to access S-linked glycopeptides by Fmoc SPPS using unprotected carbohydrates is reported. The utility of the method was demonstrated with the solid phase synthesis of a MUC1 fragment (20 mer) containing two glycosyla