New imidazo[1,2-b]pyrazoles as anticancer agents: Synthesis, biological evaluation and structure activity relationship analysis

Autor: Christelle Pillard, Gérald Guillaumet, Philippe Bernard, Robert Kiss, Mathieu Marchivie, Stéphane Massip, Christian Jarry, Sandrine Grosse, Véronique Mathieu

Publikováno v: European Journal of Medicinal Chemistry. 84:718-730

Synthesis and functionalization strategies of the imidazo[1,2-b]pyrazole core were developed giving a rapid access to three series of novel imidazo[1,2-b]pyrazole type derivatives: C-2/C-6/C-7 trisubstituted, C-2/C-3/C-6 tri(hetero)arylated and C-2/C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ac5db9b860d065b798371dc7cc9355
https://doi.org/10.1016/j.ejmech.2014.07.057

Access to Imidazo[1,2-a]imidazolin-2-ones and Functionalization through Suzuki-­Miyaura Cross-Coupling Reactions

Autor: Stéphane Massip, Sandrine Grosse, Gérald Guillaumet, Christian Jarry, Jean-Michel Léger, Philippe Bernard, Christelle Pillard, Franck Himbert

Publikováno v: European Journal of Organic Chemistry. 2013:4146-4155

We report herein a synthetic pathway to new 6(5)-bromo-5(6)-methylimidazo[1,2-a]imidazolin-2-ones. The synthetic potential of these scaffolds was demonstrated by displacing bromine by Suzuki–Miyaura cross-coupling reactions. A large panel of boroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b20eb2729e4e9f886e1c13ad8372b9ca
https://doi.org/10.1002/ejoc.201300268

ChemInform Abstract: Ligandless Palladium-Catalyzed Regioselective Direct C-H Arylation of Imidazo[1,2-a]imidazole Derivatives

Autor: Stéphane Massip, Mathieu Marchivie, Christelle Pillard, Gérald Guillaumet, Philippe Bernard, Christian Jarry, Sandrine Grosse

Publikováno v: ChemInform. 47

A wide range of 3,6-di(hetero) arylated title imidazole derivatives are obtained with good functional group tolerance by C-3 pallado-catalyzed functionalization performed with low catalyst loading.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63ce430f749295c347ea8e81cd835ecd
https://doi.org/10.1002/chin.201602118

Synthesis of Nitro N,N′-Dipyridinylamines via Oxidative Nucleophilic Substitution of Hydrogen

Autor: Adriana-Luminita Finaru, Gérald Guillaumet, Christelle Pillard, Oana-Irina Patriciu, Ioan Sandulescu

Publikováno v: Synthesis. 2007:3868-3876

The amination of 3-nitropyridines with aromatic amides generated from various aminopyridine derivatives proceeded unexpectedly in the position PARA to the nitro group, giving the oxidative nucleophilic substitution of hydrogen (ONSH) derived compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25f6e371f0c99a5155d228706e7575ee
https://doi.org/10.1055/s-2007-990896

Ligandless Palladium-Catalyzed Regioselective Direct C-H Arylation of Imidazo[1,2-a]imidazole Derivatives

Autor: Gérald Guillaumet, Mathieu Marchivie, Sandrine Grosse, Stéphane Massip, Philippe Bernard, Christelle Pillard, Christian Jarry

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, 2015, 80 (17), pp.8539-8551. ⟨10.1021/acs.joc.5b00534⟩
Journal of Organic Chemistry, American Chemical Society, 2015, 80 (17), pp.8539-8551. ⟨10.1021/acs.joc.5b00534⟩

International audience; Herein a novel access to functionalizable 6-substituted imidazo[1,2-a]imidazole scaffolds is described. The reactivity of this heterobicyclic unit toward direct C-H arylation was studied, and conditions allowing regioselective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f378e61100416fd45eacc25e0c6247c4
https://hal.science/hal-01204848