Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christelle Joseph"'
Autor:
Amir T. Fathi, Seth A. Wander, Traci M. Blonquist, Andrew M. Brunner, Philip C. Amrein, Jeffrey Supko, Nicole M. Hermance, Amity L. Manning, Hossein Sadrzadeh, Karen K. Ballen, Eyal C. Attar, Timothy A. Graubert, Gabriela Hobbs, Christelle Joseph, Ashley M. Perry, Meghan Burke, Regina Silver, Julia Foster, Meghan Bergeron, Aura Y. Ramos, Tina T. Som, Kaitlyn M. Fishman, Kristin L. McGregor, Christine Connolly, Donna S. Neuberg, Yi-Bin Chen
Publikováno v:
Haematologica, Vol 102, Iss 4 (2017)
Aberrant expression of aurora kinase A is implicated in the genesis of various neoplasms, including acute myeloid leukemia. Alisertib, an aurora A kinase inhibitor, has demonstrated efficacy as monotherapy in trials of myeloid malignancy, and this ef
Externí odkaz:
https://doaj.org/article/3505135afba4471f95cb8a4b2bb74035
Autor:
Yi-Bin Chen, Gabriela S. Hobbs, Meghan Burke, Philip C. Amrein, Seth A. Wander, Ilene Galinsky, Donna Neuberg, Christelle Joseph, Darrell R. Borger, Kimberly Straley, Aura Y. Ramos, Richard Stone, Hua Yang, Eyal C. Attar, Karen K. Ballen, Hossein Sadrzadeh, Sam Agresta, Ashley M. Perry, Andrew M. Brunner, Katharine E. Yen, Timothy A. Graubert, Anthony J. Iafrate, Amir T. Fathi, Christine Connolly, Sophia Adamia
Publikováno v:
Cancer. 125:541-549
Background Acute myeloid leukemia (AML) cells harboring mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) produce the oncometabolite 2-hydroxyglutarate (2HG). This study prospectively evaluated the 2HG levels, IDH1/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e9a13f69e5723d802788b9dbec963a
https://doi.org/10.1002/cncr.31729
https://doi.org/10.1002/cncr.31729
Autor:
Tina T. Som, Malgorzata McMasters, Philip C. Amrein, Kaitlyn M. Fishman, Daniela Hernandez, Gabriela S. Hobbs, Andrew M. Brunner, Robin Joyce, Kristin McGregor, Karen K. Ballen, Meghan Bergeron, Donna Neuberg, Traci M. Blonquist, Jessica Rae, Ashley M. Perry, David Avigan, Tanya T. Behnan, Mark J. Levis, Jenna A. Moran, Amir T. Fathi, Meghan Burke, Christine Connolly, Aura Y. Ramos, Christelle Joseph, Julia Foster, Emma Logan
Publikováno v:
Cancer. 124:306-314
BACKGROUND Cabozantinib, a tyrosine kinase inhibitor of FMS-like tyrosine kinase 3 (FLT3), MET, AXL, vascular endothelial growth factor receptor, and KIT, is approved for use in multiple malignancies. We assessed the safety and tolerability of caboza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65f71b564f4aebcc1cba78f2d092bb55
https://doi.org/10.1002/cncr.31038
https://doi.org/10.1002/cncr.31038
Autor:
Christelle Joseph, Karen K. Ballen, Amir T. Fathi, Ashley M. Perry, Marla M. Jalbut, Gabriela S. Hobbs, Philip C. Amrein, Andrew M. Brunner
The lethality of acute myeloid leukemia (AML) is often associated with infectious complications, caused either by direct disruption of normal hematopoiesis by the disease or by marrow suppression d...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390f543168b17b58b2e8d06875b35a03
https://europepmc.org/articles/PMC6197051/
https://europepmc.org/articles/PMC6197051/
Autor:
Tina T. Som, Gabriela S. Hobbs, Meghan Bergeron, Traci M. Blonquist, Yi Bin Chen, Meghan Burke, Regina Silver, Eyal C. Attar, Kristin McGregor, Hossein Sadrzadeh, Philip C. Amrein, Ashley M. Perry, Christelle Joseph, Julia Foster, Kaitlyn M. Fishman, Nicole M. Hermance, Jeffrey G. Supko, Donna Neuberg, Karen K. Ballen, Timothy A. Graubert, Aura Y. Ramos, Seth A. Wander, Andrew M. Brunner, Christine Connolly, Amir T. Fathi, Amity L. Manning
Publikováno v:
Haematologica
Aberrant expression of aurora kinase A is implicated in the genesis of various neoplasms, including acute myeloid leukemia. Alisertib, an aurora A kinase inhibitor, has demonstrated efficacy as monotherapy in trials of myeloid malignancy, and this ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1838aaf46a04d8c3badd2e238da6be65
https://pubmed.ncbi.nlm.nih.gov/28034990
https://pubmed.ncbi.nlm.nih.gov/28034990
Autor:
Daniela Hernandez, Emma Logan, Aura Y. Ramos, Donna Neuberg, Andrew M. Brunner, Christine Connolly, David Avigan, Christelle Joseph, Malgorzata McMasters, Philip C. Amrein, Karen K. Ballen, Tina T. Som, Traci M. Blonquist, Gabriela S. Hobbs, Mark J. Levis, Ashley M. Perry, Robin Joyce, Amir T. Fathi
Publikováno v:
Blood. 128:5218-5218
Cabozantinib is a multi-targeted tyrosine kinase inhibitor (TKI) of FLT3, MET, AXL, VEGFR, and KIT, all of which are implicated in the pathogenesis of acute myeloid leukemia (AML). Cabozantinib has been studied in clinical trials of solid tumors, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a1fd9fb0d257b68ff3774dfcdf395de
https://doi.org/10.1182/blood.v128.22.5218.5218
https://doi.org/10.1182/blood.v128.22.5218.5218
Autor:
Donna Neuberg, Gabriela S. Hobbs, Richard Stone, Karen K. Ballen, Aura Y. Ramos, Amir T. Fathi, Seth A. Wander, Hossein Sadrzadeh, Christelle Joseph, Sophia Adamia, Yi-Bin Chen, Meghan Burke, Anthony J. Iafrate, Ilene Galinsky, Ashley M. Perry, Philip C. Amrein, Andrew M. Brunner, Darrell R. Borger, Regina Silver
Publikováno v:
Blood. 126:2597-2597
Mutations in genes encoding the isocitrate dehydrogenase 1/2 (IDH 1/2) enzymes increase production of the oncometabolite 2-hydroxyglutarate (2HG), resulting in elevated 2HG in patients with IDH-mutant AML. This may allow for non-invasive diagnostic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5f5a4c79502307f0dc8c98fd5f7b4a6
https://doi.org/10.1182/blood.v126.23.2597.2597
https://doi.org/10.1182/blood.v126.23.2597.2597
Autor:
Donna Neuberg, Amir T. Fathi, Gabriela S. Hobbs, Eyal C. Attar, Ashley M. Perry, Philip C. Amrein, Andrew M. Brunner, Christelle Joseph, Karen K. Ballen, Marla M. Jalbut
Publikováno v:
Journal of Clinical Oncology. 33:7065-7065
7065 Background: Infectious complications are common during AML treatment, partly related to cytopenias during standard induction. It is less clear whether the same degree of infectious complicatio...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df643adbf7b2e22a7f2751aea333e491
https://doi.org/10.1200/jco.2015.33.15_suppl.7065
https://doi.org/10.1200/jco.2015.33.15_suppl.7065
Autor:
Timothy A. Graubert, Traci M. Blonquist, Donna Neuberg, Andrew M. Brunner, Regina Silver, Steven L. McAfee, Yi-Bin Chen, Christelle Joseph, Karen K. Ballen, Eyal C. Attar, Ashley M. Perry, Meghan Burke, Seth A. Wander, Philip C. Amrein, Aura Y. Ramos, Amir T. Fathi, Christine Connolly
Publikováno v:
Blood. 124:119-119
The aurora kinases play an essential role in regulating mitosis and cell division. Over-expression of aurora kinases A and B has been associated with poor-risk features in acute myeloid leukemia (AML). Preclinical studies suggest that small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8618eb7295e0d8b4e32d094ccde861f2
https://doi.org/10.1182/blood.v124.21.119.119
https://doi.org/10.1182/blood.v124.21.119.119