Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christelle Gasser"'
Autor:
Lukas-Adrian Gurzeler, Marion Link, Yvonne Ibig, Isabel Schmidt, Olaf Galuba, Julian Schoenbett, Christelle Gasser-Didierlaurant, Christian N. Parker, Xiaohong Mao, Francis Bitsch, Markus Schirle, Philipp Couttet, Frederic Sigoillot, Jana Ziegelmüller, Anne-Christine Uldry, Wojciech Teodorowicz, Niko Schmiedeberg, Oliver Mühlemann, Jürgen Reinhardt
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113159- (2023)
Externí odkaz:
https://doaj.org/article/a17f69f34eb64c599e2fdcd86f226d38
Autor:
Juerg Schwaller, Stefan Knapp, Sandrine Meyer-Monard, Andrea Biondi, Christelle Gasser, Panagis Filippakopoulos, Oleg Fedorov, Alex N. Bullock, Vanda Pogacic
Supplementary Figure 1 from Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0bdb35e928fcf24388acd07b8b81ac
https://doi.org/10.1158/0008-5472.22367984
https://doi.org/10.1158/0008-5472.22367984
Autor:
Juerg Schwaller, Stefan Knapp, Sandrine Meyer-Monard, Andrea Biondi, Christelle Gasser, Panagis Filippakopoulos, Oleg Fedorov, Alex N. Bullock, Vanda Pogacic
Supplementary Table 1 from Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c894b65e42f8081e7f01e99a16e4a4
https://doi.org/10.1158/0008-5472.22367978.v1
https://doi.org/10.1158/0008-5472.22367978.v1
Autor:
Juerg Schwaller, Stefan Knapp, Sandrine Meyer-Monard, Andrea Biondi, Christelle Gasser, Panagis Filippakopoulos, Oleg Fedorov, Alex N. Bullock, Vanda Pogacic
Supplementary Legends from Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b841feeb69084c3d13888dd2cac165a
https://doi.org/10.1158/0008-5472.22367981
https://doi.org/10.1158/0008-5472.22367981
Autor:
Juerg Schwaller, Stefan Knapp, Sandrine Meyer-Monard, Andrea Biondi, Christelle Gasser, Panagis Filippakopoulos, Oleg Fedorov, Alex N. Bullock, Vanda Pogacic
Much attention has recently been focused on PIM kinases as potential targets for the treatment of hematopoietic malignancies and some solid cancers. Using protein stability shift assays, we identified a family of imidazo[1,2-b]pyridazines to specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6ca27e1243214b78aaa1124a18f116
https://doi.org/10.1158/0008-5472.c.6495761.v1
https://doi.org/10.1158/0008-5472.c.6495761.v1
Publikováno v:
Haematologica, Vol 95, Iss 6 (2010)
The identification as cooperating targets of Proviral Integrations of Moloney virus in murine lymphomas suggested early on that PIM serine/threonine kinases play an important role in cancer biology. Whereas elevated levels of PIM1 and PIM2 were mostl
Externí odkaz:
https://doaj.org/article/e779135f862f4e7d8b9fe09cb0beb315
Publikováno v:
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
The identification as cooperating targets of Proviral Integrations of Moloney virus in murine lymphomas suggested early on that PIM serine/threonine kinases play an important role in cancer biology. Whereas elevated levels of PIM1 and PIM2 were mostl
Autor:
Stefan Knapp, Panagis Filippakopoulos, Laurent Brault, Franz Bracher, Jürg Schwaller, Alex N. Bullock, Christelle Gasser, Kilian Huber, Jörg Trappe, Doriano Fabbro, Oleg Fedorov
Publikováno v:
Journal of Medicinal Chemistry
JOURNAL OF MEDICINAL CHEMISTRY
JOURNAL OF MEDICINAL CHEMISTRY
Development of both potent and selective kinase inhibitors is a challenging task in modern drug discovery. The innate promiscuity of kinase inhibitors largely results from ATP mimetic binding to the kinase hinge region. We present a novel class of su
Autor:
Laurent Brault, Rebekka Grundler, Vanda Pogacic, Juerg Schwaller, Justus Duyster, G. Berridge, Christelle Gasser, Antonello Villa, Christine Dierks, Stefan Knapp, Tobias Dechow, Sabine Woetzel, Anke Spoo, Andrea Biondi, Alex N. Bullock, Sabine Ehret
Publikováno v:
The Journal of Experimental Medicine
FLT3-ITD–mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD–mediated transformation, we performed bone marrow reconstitution assays. Unexpectedly, FLT3-ITD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d43b6e0eb2aef17a5b7dc88a50d2fa
http://hdl.handle.net/10281/18542
http://hdl.handle.net/10281/18542
Autor:
Rebekka Grundler, Anke Spoo, Alec Bullock, Laurent Brault, Sabine Woetzel, Sabine Ehret, Tobias Dechow, Stefan Knapp, Martjin Nawijn, Andrea Biondi, Juerg Schwaller, Justus Duyster, G. Berridge, Christelle Gasser, Christine Dierks
Publikováno v:
BLOOD. 112(11)
Previous work has shown that FLT3-ITD mediated leukemogenesis is associated with increased expression of PIM1 and PIM2 serine/threonine kinases. Here we show that retroviral expression of FLT3-ITD could not compensate impaired clonogenic in vitro gro