Výsledky vyhledávání - "Christelle Faveau"

Synthetic studies on a phenyl-laulimalide analogue

Autor: Jean-Pierre Gesson, Ulrich Koert, Christelle Faveau, Sandra Gebhardt, Tobias Mahnke, Martine Mondon

Publikováno v: Tetrahedron Letters. 47:8305-8308

An analogue of the paclitaxel-like antimicrotubule agent laulimalide with a phenyl in place of the dihydropyran has been synthesized. The fragments C 1 –C 14 and C 15 –C 28 were coupled via a stereoselective intermolecular allylboration. Ring clo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7489232edaaf524f2c09369a999fe410
https://doi.org/10.1016/j.tetlet.2006.09.104

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Stimulation of Wild-Type, F508del- and G551D-CFTR Chloride Channels by Non-Toxic Modified pyrrolo[2,3-b]pyrazine Derivatives

Autor: Mathilde Jollivet, Arnaud Billet, Frédéric Becq, Luc Dannhoffer, Christelle Faveau, Patricia Melin-Heschel

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Frontiers, 2011, 2, ⟨10.3389/fphar.2011.00048⟩
Frontiers in Pharmacology, Vol 2 (2011)

International audience; Cystic fibrosis (CF) is a major inherited disorder involving abnormalities of fluid and electrolyte transport in a number of different organs due to abnormal function of cystic fibrosis transmembrane conductance regulator (CFT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff4549110743c334b46b1488c2b0b75

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Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

Autor: Caroline Norez, Yvette Mettey, Frédéric Becq, Christian Rogier, Christelle Faveau, Sabrina Noël

Publikováno v: The Journal of pharmacology and experimental therapeutics. 319(1)

The cystic fibrosis transmembrane conductance regulator (CFTR) represents the main Cl(-) channel in the apical membrane of epithelial cells for cAMP-dependent Cl(-) secretion. Here we report on the synthesis and screening of a small library of 6-phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1898a7601cf0ad43cb35429a9aa0b75
https://pubmed.ncbi.nlm.nih.gov/16829626

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