Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing

Autor: Françoise Debart, Christelle Dupouy, Jean-Jacques Vasseur

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 436-469 (2018)

Oligonucleotides (ONs) have been envisaged for therapeutic applications for more than thirty years. However, their broad use requires overcoming several hurdles such as instability in biological fluids, low cell penetration, limited tissue distributi

Externí odkaz: https://doaj.org/article/940694118b764537a14dbeff710a2beb

Synthesis and properties of RNA constrained by a 2’‐O‐disulfide bridge

Autor: Diallo Traoré, Elisa Biecher, Manon Mallet, Sonia Rouanet, Dr. Jean‐Jacques Vasseur, Prof. Michael Smietana, Dr. Christelle Dupouy

Publikováno v: ChemistryOpen, Vol 13, Iss 8, Pp n/a-n/a (2024)

Abstract We recently reported the properties of RNA hairpins constrained by a dimethylene (DME) disulfide (S−S) linker incorporated between two adjacent nucleosides in the loop and showed that this linker locked the hairpin conformation thus distur

Externí odkaz: https://doaj.org/article/bb0e8db1315b4704969c64fe26eb9c19

Difluorophosphonylated Allylic Ether Moiety as a 2′-Modification of RNA-Type Molecules: Synthesis, Thermal, and Metabolic Studies

Autor: Jean-Jacques Vasseur, Sonia Rouanet, Christelle Dupouy, Emmanuel Pfund, Rémi Legay, Thierry Lequeux, Cyril Lebargy

Publikováno v: Organic Letters
Organic Letters, American Chemical Society, 2019, 21 (12), pp.4803-4807. ⟨10.1021/acs.orglett.9b01689⟩

The first synthesis of oligonucleotides incorporating URF, a uridine modified with a difluorophosphonylated allylic ether onto the 2'-position, is described. Fluorinated homouridylates and miR-342-3p analogues are efficiently prepared. UV-melting exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3032e109ac977bfd1015c3e8aa14371
https://doi.org/10.1021/acs.orglett.9b01689

Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing

Autor: Jean-Jacques Vasseur, Françoise Debart, Christelle Dupouy

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 436-469 (2018)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2018, 14 (26), pp.436-469. ⟨10.3762/bjoc.14.32⟩

Oligonucleotides (ONs) have been envisaged for therapeutic applications for more than thirty years. However, their broad use requires overcoming several hurdles such as instability in biological fluids, low cell penetration, limited tissue distributi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93967b9516c1e8fb811d6da5180cd0f3
https://doi.org/10.3762/bjoc.14.32

A 2',2'-disulfide-bridged dinucleotide conformationally locks RNA hairpins

Autor: Frédéric Beltran, Christelle Dupouy, Annabelle Biscans, Jean-Jacques Vasseur, Florian Gauthier, Françoise Debart

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (17), pp.3181-3188. ⟨10.1039/c8ob00328a⟩

International audience; The synthesis and the impact of a disulfide bridge between 2'-O-positions of two adjacent nucleotides in an RNA duplex and in the loop of RNA hairpins are reported. The incorporation of this 2',2'-disulfide (S-S) bridge enable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5286befd42855135c5e9c6540f4fd7e5
https://pubmed.ncbi.nlm.nih.gov/29645048