Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Christelle Doebelin"'
Autor:
Mohammed Amir, Sweena Chaudhari, Ran Wang, Sean Campbell, Sarah A. Mosure, Laura B. Chopp, Qun Lu, Jinsai Shang, Oliver B. Pelletier, Yuanjun He, Christelle Doebelin, Michael D. Cameron, Douglas J. Kojetin, Theodore M. Kamenecka, Laura A. Solt
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3733-3749.e8 (2018)
Summary: RORγt is well recognized as the lineage-defining transcription factor for T helper 17 (TH17) cell development. However, the cell-intrinsic mechanisms that negatively regulate TH17 cell development and autoimmunity remain poorly understood.
Externí odkaz:
https://doaj.org/article/5543335c68ab4cb7b10b6c0611e56c76
Autor:
Jing Zhao, Lei Zhang, Xiaodong Mu, Christelle Doebelin, William Nguyen, Callen Wallace, Daniel P Reay, Sara J McGowan, Lana Corbo, Paula R Clemens, Gabriela Mustata Wilson, Simon C Watkins, Laura A Solt, Michael D Cameron, Johnny Huard, Laura J Niedernhofer, Theodore M Kamenecka, Paul D Robbins
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2004663 (2018)
Nuclear factor κB (NF-κB) is a transcription factor important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, and senescence. Dysregulation of NF-κB and its upstream regulator IκB kinase (IKK) contributes to the pa
Externí odkaz:
https://doaj.org/article/67ff24f19cc84f6982b4b66d85ad2d8d
Autor:
Timothy S. Strutzenberg, Ruben D. Garcia-Ordonez, Dean P. Edwards, Theodore M. Kamenecka, Mi Ra Chang, Patrick R. Griffin, Scott J. Novick, Christelle Doebelin, Yuanjun He, Yingmin Zhu
Publikováno v:
J Mol Biol
The retinoic acid receptor-related orphan receptor γ (RORγ) is a ligand-dependent transcription factor of the nuclear receptor super family that underpins metabolic activity, immune function, and cancer progression. Despite being a valuable drug ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b73eb4a71cc9b37805f02c70183195
https://pubmed.ncbi.nlm.nih.gov/34547329
https://pubmed.ncbi.nlm.nih.gov/34547329
Autor:
Theodore M. Kamenecka, Angelo Blasio, Simone M. Giovanetti, Michael D. Cameron, Robert O. Messing, Matthew B. Pomrenze, Jingyi Wang, Christelle Doebelin, Jon Lindstrom, Holly L. Chapman, Victor Liaw, Alexander Kuryatov, Li Lin
Publikováno v:
Neuropsychopharmacology
There is increasing interest in developing drugs that act at α4β2 nicotinic acetylcholine receptors (nAChRs) to treat alcohol use disorder. The smoking cessation agent varenicline, a partial agonist of α4β2 nAChRs, reduces alcohol intake, but its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea2407be6ea72e8212bc31f113908ff
https://europepmc.org/articles/PMC6901472/
https://europepmc.org/articles/PMC6901472/
Autor:
Michael D. Cameron, Theodore M. Kamenecka, Ruben D. Garcia-Ordonez, Venkatasubramanian Dharmarajan, Mi Ra Chang, Li Lin, Christelle Doebelin, Dana S. Kuruvilla, Rémi Patouret, Scott J. Novick, Patrick R. Griffin
Publikováno v:
ChemMedChem. 11:2607-2620
The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-molecule repressors (inverse agonists) targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a329b89d72ab44a740ec75f0d1b3b9a
https://doi.org/10.1002/cmdc.201600491
https://doi.org/10.1002/cmdc.201600491
Autor:
Abba E. Leffler, Jingyi Wang, Theodore M. Kamenecka, Alexander Kuryatov, Jon Lindstrom, Christelle Doebelin, Jack Norleans
Publikováno v:
J Biol Chem
Nicotinic acetylcholine receptor (nAChR) ligands that lack agonist activity but enhance activation in the presence of an agonist are called positive allosteric modulators (PAMs). nAChR PAMs have therapeutic potential for the treatment of nicotine add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e8f4a8f34afa413d37f28e4a3bba33
https://pubmed.ncbi.nlm.nih.gov/31221718
https://pubmed.ncbi.nlm.nih.gov/31221718
Autor:
Michael D. Cameron, William R. Roush, Laura A. Solt, Theodore M. Kamenecka, Marcel Koenig, Susan Kahn, Sean Campbell, Li Lin, Ruben D. Garcia-Ordonez, Mi Ra Chang, Philippe Nuhant, Naresh Kumar, Yuanjun He, Christelle Doebelin, Patrick R. Griffin
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 15(6)
Background: Despite a massive industry endeavor to develop RORγ-modulators for autoimmune disorders, there has been no indication of efforts to target the close family member RORα for similar indications. This may be due to the misconception that R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6308426c3777c262b337eb68e69a9a1d
https://pubmed.ncbi.nlm.nih.gov/30799793
https://pubmed.ncbi.nlm.nih.gov/30799793
Autor:
Scott J. Novick, Ruben D. Garcia-Ordonez, Mi Ra Chang, Venkatasubramanian Dharmarajan, Sean Campbell, Rémi Patouret, Anthony Ciesla, Theodore M. Kamenecka, Laura A. Solt, Patrick R. Griffin, Christelle Doebelin
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(19)
We sought to develop RORβ-selective probe molecules in order to investigate the function of the receptor in vitro and in vivo and its role in the pathophysiology of disease. To accomplish this, we modified a potent dual RORβ/RORγ inverse agonist f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95debe5d3c8c2418a75e2024fc194c33
https://pubmed.ncbi.nlm.nih.gov/30143422
https://pubmed.ncbi.nlm.nih.gov/30143422
Autor:
Lana Corbo, Michael D. Cameron, Lei Zhang, Johnny Huard, Sara J. McGowan, Xiaodong Mu, Jing Zhao, William Nguyen, Daniel P. Reay, Callen T. Wallace, Paul D. Robbins, Gabriela Mustata Wilson, Paula R. Clemens, Theodore M. Kamenecka, Simon C. Watkins, Laura A. Solt, Christelle Doebelin, Laura J. Niedernhofer
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2004663 (2018)
PLoS Biology
PLoS Biology
Nuclear factor κB (NF-κB) is a transcription factor important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, and senescence. Dysregulation of NF-κB and its upstream regulator IκB kinase (IKK) contributes to the pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4e9e79f8c2408a7869c05a1a87ab68
https://doaj.org/article/67ff24f19cc84f6982b4b66d85ad2d8d
https://doaj.org/article/67ff24f19cc84f6982b4b66d85ad2d8d
Autor:
Ruben D. Garcia-Ordonez, Dana S. Kuruvilla, Mi Ra Chang, Christelle Doebelin, Theodore M. Kamenecka, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Scott J. Novick
Publikováno v:
ACS Chemical Biology. 11:1012-1018
The T cell specific RORγ isoform RORγt has been shown to be the key lineage-defining transcription factor to initiate the differentiation program of TH17 and Tc17 cells, cells that have demonstrated anti-tumor efficacy. RORγt controls gene network
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b1dd2cf17d7e4614bf177ba6c49be0
https://doi.org/10.1021/acschembio.5b00899
https://doi.org/10.1021/acschembio.5b00899