Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Autor: Christelle David, Nele Vandervoort, Damien Fleury, Denis Annoot, Laëtitia Cherel, Willem Jan Hengeveld, Thierry Christophe, Sameh H. Soror, Agnès Marie Joncour, Christopher Gaëtan Housseman, Alain Monjardet, R Galien, Patrick Mollat, Reginald Brys, Veronique Roncoroni, Luce Lepissier, Natacha Bienvenu, Lionel Vercheval, Alexandre Wohlkonig, Christophe Peixoto, Jörg Heiermann, Katja Conrath, Mia Jans, Sandrine Le Tallec, Bertrand Heckmann, Robert Touitou, Nicolas Desroy, Jan Steyaert, Virginie Labeguere, Gregor Pilzak, Ellen van der Aar, Xavier Marie Bock, Nicolas Triballeau, Emanuelle Wakselman

Publikováno v: Journal of Medicinal Chemistry. 60:7371-7392

Autotaxin (ATX) is a secreted enzyme playing a major role in the production of lysophosphatidic acid (LPA) in blood through hydrolysis of lysophosphatidyl choline (LPC). The ATX-LPA signaling axis arouses a high interest in the drug discovery industr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bab957aedfbab6da364d90d0e33f16
https://doi.org/10.1021/acs.jmedchem.7b00647

Evaluation of Matrix Metalloproteinases in Atherosclerosis Using a Novel Noninvasive Imaging Approach

Autor: Sébastien Ballet, Irène Brigger, Claire Corot, Soizic Le Greneur, Jean-Baptiste Michel, Olivier Rousseaux, Patrick Bruneval, Marc Port, Tanja Ouimet, Christelle David, Bernard P. Roques, Vardan Amirbekian, Eric Lancelot, Juan Gilberto S. Aguinaldo, Jean-Sébastien Raynaud, Zahi A. Fayad, Fabien Hyafil, Esad Vucic, Smbat Amirbekian, Henri R. Lijnen

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 28:425-432

Objective— Despite great advances in our knowledge, atherosclerosis continues to kill more people than any other disease in the Western world. This is because our means of identifying truly vulnerable patients is limited. Prediction of atherosclero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35fe087d7a65d66f8704a218ddae446
https://doi.org/10.1161/atvbaha.107.149666

High-performance liquid chromatographic study of the interactions between immobilized β-cyclodextrin polymers and hydrophobically end-capped polyethylene glycols

Autor: Christelle David, Marie Claude Millot, Bernard Sebille

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 753:93-99

The formation of inclusion complexes between polyethylene glycols (PEGs) bearing hydrophobic ends (naphtyl and phenyladamantyl) and beta-cyclodextrin polymers (poly beta-CD) immobilized onto silica particles was studied by high-performance liquid chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cefc1213d942f9f7fc5a7971f5cabf2
https://doi.org/10.1016/s0378-4347(00)00501-6

Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

Autor: Nadia De Mota, Marie-Claude Fournie-Zaluski, Bernard P. Roques, Sophie Danascimento, Aurélie Mothé, Christelle David, Hervé Meudal, Laurent Bischoff, Catherine Llorens-Cortes

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 1999, 42 (25), pp.5197-5211. ⟨10.1021/jm9903040⟩
Journal of Medicinal Chemistry, 1999, 42 (25), pp.5197-5211. ⟨10.1021/jm9903040⟩

The study of the physiological roles of the membrane-bound zinc-aminopeptidase A (glutamyl aminopeptidase, EC 3.4.11.7) needs the design of efficient and selective inhibitors of this enzyme. An acute exploration of aminopeptidase A active site was pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71576b35e86aacdca946d512ddb43e6
https://doi.org/10.1021/jm9903040

Sleep as an Activity of Daily Living and Improved Outcomes in Acute Care

Autor: Ryan Scott, Julia Meireles, Zainab Rasheed, Bridget Higgy, Melissa Johnson, Peter Farrehi, Giancarlo Vanini, Steven T Heidt, Kristen Clore, Brittany Gappy, Christelle David, Mary Barber

Publikováno v: The American Journal of Occupational Therapy. 70:7011505170p1-7011505170p1

Date Presented 4/9/2016 Occupational therapy sleep tool intervention demonstrates a positive effect on pain reduction associated with sleep deprivation. To improve patient outcomes, hospital-based occupational therapist roles should routinely include

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaa91ac459dd40f12684a54b8b6ef6a6
https://doi.org/10.5014/ajot.2016.70s1-po6112