Výsledky vyhledávání - "Christelle Bonvin"

Apoptosis Stimulated by the 91-kDa Caspase Cleavage MEKK1 Fragment Requires Translocation to Soluble Cellular Compartments

Autor: Matthew B. Jarpe, Gary L. Johnson, Thomas K. Schlesinger, Christian Widmann, Gary R. Fanger, Christelle Bonvin, Jean-René Cardinaux

Publikováno v: Journal of Biological Chemistry. 277:10283-10291

MEKK1, a 196-kDa mitogen-activated protein kinase (MAPK) kinase kinase, generates anti-apoptotic signaling as a full-length protein but induces apoptosis when cleaved by caspases. Here, we show that caspase-dependent cleavage of MEKK1 relocalizes the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2411c2c5fb973c6b553ac1edb5362f75
https://doi.org/10.1074/jbc.m106885200

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Role of the amino-terminal domains of MEKKs in the activation of NFκB and MAPK pathways and in the regulation of cell proliferation and apoptosis

Autor: Pär Gerwins, Gary L. Johnson, Audrey Guillon, Miguel X. van Bemmelen, Christian Widmann, Christelle Bonvin

Publikováno v: Cellular Signalling. 14:123-131

Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) kinases (MEKKs) are serine/threonine kinases that are upstream regulators of MAPKs. Here, the role of the amino-terminal (N-terminal) domain of MEKK1-4 o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0356fe6ae1f58922c8b64734da81c467
https://doi.org/10.1016/s0898-6568(01)00219-4

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