Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Christelle Bolea"'
1
Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders
Autor: Jacob Raber, Matthew J. Davis, Isabelle Royer-Urios, Christelle Bolea, Simon T. Bate, Susan E. Browne, Brice Campo, Francoise Girard, Massimiliano Fonsi, Sylvain Celanire, Jason M. Uslaner, Robert M. Duvoisin, Mikhail Kalinichev, Ian J. Reynolds, Sonia Poli, Emmanuel Le Poul
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 350:495-505
There is growing evidence that activation of metabotropic glutamate receptor 4 (mGlu4) leads to anxiolytic- and antipsychotic-like efficacy in rodent models, yet its relevance to depression-like reactivity remains unclear. Here, we present the pharma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f714df4a874e499ee5550929871e889
https://doi.org/10.1124/jpet.114.214437
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2
mGluR5 Negative Allosteric Modulators Overview: A Medicinal Chemistry Approach Towards a Series of Novel Therapeutic Agents
Autor: Robert Johannes Lütjens, Vincent Mutel, Bernard Ludwig, Beatrice Bonnet, Jean-Philippe Rocher, Emmanuel Le Poul, Christelle Bolea, Mark Epping-Jordan, Bessis Anne-Sophie, Sonia Poli
Publikováno v: Current Topics in Medicinal Chemistry. 11:680-695
Allosteric modulators of metabotropic glutamate receptors (mGluR) subtypes 1-8 have been shown to offer a valid way to develop small molecule non aminoacid-like therapeutics that can be administered orally and that readily cross the blood-brain barri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb97f5662dfd1f5a23e7f8eed1404b9d
https://doi.org/10.2174/1568026611109060680
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5
Akademický článek
Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson’s Disease
Autor: Mark P. Epping-Jordan, Françoise Girard, Anne-Sophie Bessis, Vincent Mutel, Christelle Boléa, Francis Derouet, Abdelhak Bessif, Brice Mingard, Stéphanie Barbier, Justine S. Paradis, Jean-Philippe Rocher, Robert Lütjens, Mikhail Kalinichev, Sonia Poli
Publikováno v: Cells, Vol 12, Iss 7, p 1004 (2023)
Parkinson’s disease (PD) patients suffer not only from the primary motor symptoms of the disease but also from a range of non-motor symptoms (NMS) that cause disability and low quality of life. Excessive glutamate activity in the basal ganglia resu
Externí odkaz: https://doaj.org/article/ac27149e13ab4f06962a2c0891cfc4ae
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7
Development of new camphor based N,S chiral ligands and their application in transfer hydrogenation
Autor: Arnaud, Gayet, Christelle, Bolea, Pher G, Andersson
Publikováno v: Organicbiomolecular chemistry. 2(13)
A new class of N,S-containing chiral compounds based on the camphor scaffold have been synthesised and evaluated as chiral catalysts in the transfer hydrogenation of acetophenone. The best results were achieved using compound 6a as the ligand and [Ir
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e58cbc4476f49b352b7d835b1f4f6c1
https://pubmed.ncbi.nlm.nih.gov/15227541
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