Overexpression of active Aurora-C kinase results in cell transformation and tumour formation.

Autor: Jabbar Khan, Frédéric Ezan, Jean-Yves Crémet, Alain Fautrel, David Gilot, Marine Lambert, Christelle Benaud, Marie-Bérengère Troadec, Claude Prigent

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26512 (2011)

Aurora kinases belong to a conserved family of serine/threonine kinases key regulators of cell cycle progression. Aurora-A and Aurora-B are expressed in somatic cells and involved mainly in mitosis while Aurora-C is expressed during spermatogenesis a

Externí odkaz: https://doaj.org/article/dedfd6933cda4aa382289b011f5ee607

A novel benzodiazepine derivative that suppresses microtubule dynamics and impairs mitotic progression

Autor: Siou Ku, Mathieu Métivier, Emmanuel Gallaud, Vittoria Pirani, Alexandre Thomas, Denis Chrétien, Lorenzo Corsi, Christelle Benaud, Régis Giet, Roberta Ettari

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2020, 133 (7), pp.jcs239244. ⟨10.1242/jcs.239244⟩
Journal of Cell Science, 2020, 133 (7), pp.jcs239244. ⟨10.1242/jcs.239244⟩

International audience; A novel 2,3-benzodiazepine-4 derivative, named 1g, has recently been shown to function as an anti-proliferative compound. We now show that it perturbs the formation of a functional mitotic spindle, inducing a spindle assembly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0440ebddcc53d74dfe2ba665936dd3ba
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02543756

Drosophila Tubulin-Specific Chaperone E Recruits Tubulin around Chromatin to Promote Mitotic Spindle Assembly

Autor: Romain Gibeaux, Jean-Philippe Gagné, Laurent Richard-Parpaillon, Emmanuel Gallaud, Régis Giet, Mathieu Métivier, Christelle Benaud, Guy G. Poirier, Alexandre Thomas, Denis Chrétien, Aude Pascal

Publikováno v: Current Biology-CB
Current Biology-CB, Elsevier, 2020, ⟨10.1016/j.cub.2020.11.009⟩
Current Biology-CB, Elsevier, 2021, 31 (4), pp.684-695.e6. ⟨10.1016/j.cub.2020.11.009⟩
Current Biology-CB, 2021, 31 (4), pp.684-695.e6. ⟨10.1016/j.cub.2020.11.009⟩

International audience; Proper assembly of mitotic spindles requires microtubule nucleation not only at the centrosomes but also around chromatin. In this study, we found that the Drosophila tubulin-specific chaperone dTBCE is required for the enrich

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea72db98bb999c46a34233b4cea8da1
https://pubmed.ncbi.nlm.nih.gov/33259793

Annexin A2 is required for the early steps of cytokinesis

Autor: Claude Prigent, Svetlana Mironov, Christelle Benaud, Gaëlle Le Dez, Federico Galli, David Reboutier

Publikováno v: EMBO Reports
EMBO Reports, EMBO Press, 2015, 16 (4), pp.481-9. ⟨10.15252/embr.201440015⟩
EMBO Reports, 2015, 16 (4), pp.481-9. ⟨10.15252/embr.201440015⟩

Cytokinesis requires the formation of an actomyosin contractile ring between the two sets of sister chromatids. Annexin A2 is a calcium- and phospholipid-binding protein implicated in cortical actin remodeling. We report that annexin A2 accumulates a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a9e31f7ffecd1fb1d21d1785985e82
https://doi.org/10.15252/embr.201440015

The Drosophila Ubiquitin-Specific Protease dUSP36/Scny Targets IMD to Prevent Constitutive Immune Signaling

Autor: Jacques Baudier, Elodie Engel, Amélie Avet-Rochex, Marie Gottar, Marie-Odile Fauvarque, Emmanuel Taillebourg, Hervé Tricoire, Evelyne Bergeret, Christelle Benaud, Dominique Thevenon

Publikováno v: Cell Host & Microbe. 6(4):309-320

Summary Ubiquitin proteases remove ubiquitin monomers or polymers to modify the stability or activity of proteins and thereby serve as key regulators of signal transduction. Here, we describe the function of the Drosophila ubiquitin-specific protease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe283efb28b26326b7206832db372b5