Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Christelle, Douillet"'
Autor:
Christelle Douillet, Madison Miller, Peter H. Cable, Qing Shi, Hisham El-Masri, Tomáš Matoušek, Beverly H. Koller, David J. Thomas, Miroslav Stýblo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Although mice are widely used to study adverse effects of inorganic arsenic (iAs), higher rates of iAs methylation in mice than in humans may limit their utility as a model organism. A recently created 129S6 mouse strain in which the Borcs7/
Externí odkaz:
https://doaj.org/article/95a8b550989e4ae5bfc2097fe9026ca2
Autor:
James G. Xenakis, Christelle Douillet, Timothy A. Bell, Pablo Hock, Joseph Farrington, Tianyi Liu, Caroline E. Y. Murphy, Avani Saraswatula, Ginger D. Shaw, Gustavo Nativio, Qing Shi, Abhishek Venkatratnam, Fei Zou, Rebecca C. Fry, Miroslav Stýblo, Fernando Pardo-Manuel de Villena
Publikováno v:
Mamm Genome
Type 2 diabetes (T2D) is a complex metabolic disorder with no cure and high morbidity. Exposure to inorganic arsenic (iAs), a ubiquitous environmental contaminant, is associated with increased T2D risk. Despite growing evidence linking iAs exposure t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a92e308d995843203ddd9f4dcd9def
https://europepmc.org/articles/PMC9761582/
https://europepmc.org/articles/PMC9761582/
Publikováno v:
Chem Res Toxicol
To investigate the role of glutathione transferases (GSTs) in the metabolism of inorganic arsenic (iAs), we compared the disposition of iAs and its metabolites in wild-type mice and mice lacking genes encoding GST-P, -M and -T after exposure to 100 p
Autor:
Miroslav Styblo, Yuanyuan Li, Susan Sumner, Rowan Beck, Christelle Douillet, Madelyn C. Huang
Publikováno v:
Arch Toxicol
Inorganic arsenic (iAs) is an environmental diabetogen, but mechanisms underlying its diabetogenic effects are poorly understood. Exposures to arsenite (iAs(III)) and its methylated metabolites, methylarsonite (MAs(III)) and dimethylarsinite (DMAs(II
Autor:
Sofiane Y. Mersaoui, Cynthia Guilbert, Hsiang Chou, Christelle Douillet, D. Scott Bohle, Miroslav Stýblo, Stéphane Richard, Koren K. Mann
Publikováno v:
Archives of toxicology. 96(5)
Arsenic toxicity is a global concern to human health causing increased incidences of cancer, bronchopulmonary, and cardiovascular diseases. In human and mouse, inorganic arsenic (iAs) is metabolized in a series of methylation steps catalyzed by arsen
Autor:
Jacqueline T. Bangma, Rebecca C. Fry, Miroslav Stýblo, Lauren A. Eaves, Christelle Douillet, Fernando Pardo-Manuel de Villena
Publikováno v:
Arch Toxicol
Mice have been frequently used to study the adverse effects of inorganic arsenic (iAs) exposure in laboratory settings. Like humans, mice metabolize iAs to monomethyl-As (MAs) and dimethyl-As (DMAs) metabolites. However, mice metabolize iAs more effi
Autor:
Luz M. Del Razo, Christelle Douillet, Paige A. Bommarito, Rowan Beck, Olga L. Valenzuela, Rebecca C. Fry, G. G. García-Vargas, Mirek Styblo, Luz C. Sánchez-Peña
Publikováno v:
Journal of exposure science & environmental epidemiology
Exposure to inorganic arsenic (iAs) remains a global public health problem. Urinary arsenicals are the current gold-standard for estimating both iAs exposure and iAs metabolism. However, the distribution of these arsenicals may differ between the uri
Autor:
Beverly H, Koller, John N, Snouwaert, Christelle, Douillet, Leigh A, Jania, Hisham, El-Masri, David J, Thomas, Miroslav, Stýblo
Publikováno v:
Environmental Health Perspectives
Chronic exposure to inorganic arsenic (iAs) is a significant public health problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification and modifies risks of iAs-induced diseases. Mechanisms underlying these diseases h
Autor:
John N. Snouwaert, Miroslav Stýblo, Beverly H. Koller, David J. Thomas, Christelle Douillet, Leigh A. Jania, Hisham A. El-Masri
Publikováno v:
Environmental Health Perspectives. 128
Background: Chronic exposure to inorganic arsenic (iAs) is a significant public health problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification and modifies risk...
Autor:
Qing Shi, Kezia A. Addo, Brent C. Topping, Miroslav Styblo, Folami Y. Ideraabdullah, Rebecca C. Fry, Abhishek Venkatratnam, Christelle Douillet
Publikováno v:
Arch Toxicol
Chronic exposure to inorganic arsenic (iAs) has been linked to diabetic phenotypes in both humans and mice. However, diabetogenic effects of iAs exposure during specific developmental windows have never been systematically studied. We have previously