Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christel Valencia"'
Autor:
Timothé Maujean, Patrick Wagner, Christel Valencia, Stéphanie Riché, Xavier Iturrioz, Pascal Villa, Nicolas Girard, Julie Karpenko, Mihaela Gulea, Dominique Bonnet
Publikováno v:
Bioconjugate chemistry.
Herein, we describe a catalyst-free thia-Diels-Alder cycloaddition for the chemoselective labeling of fully deprotected phosphonodithioester-peptides in solution with fluorophores functionalized with an exocyclic diene. The reaction was optimized on
Autor:
Claire Marsol, Christel Valencia, Thierry Durroux, Marcel Hibert, Dominique Bonnet, Julie Le Merrer, Pascal Villa, Marie-Céline Frantz, Jérôme A.J. Becker, Stéphanie Loison, Elsa Pflimlin, Bernard Mouillac, Lucie P. Pellissier, Jorge Gandía
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (19), pp.8670-8692. ⟨10.1021/ACS.JMEDCHEM.8B00697⟩
Journal of Medicinal Chemistry, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (19), pp.8670-8692. ⟨10.1021/ACS.JMEDCHEM.8B00697⟩
Journal of Medicinal Chemistry, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩
International audience; Oxytocin (OT) and its receptor (OT-R) are implicated in the etiology of autism spectrum disorders (ASD), and OT-R is a potential target for therapeutic intervention. Very few nonpeptide oxytocin agonists have currently been re
Autor:
Christel Valencia, Catherine Llorens-Cortes, Céline Dujet, Pascal Villa, Thomas Roux, Dominique Bonnet, Elodie Dupuis, Marcel Hibert, Eric Trinquet, Jean-François Margathe, Xavier Iturrioz
Publikováno v:
ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2017, 12 (12), pp.925-931. ⟨10.1002/cmdc.201700106⟩
ChemMedChem, Wiley-VCH Verlag, 2017, 12 (12), pp.925-931. ⟨10.1002/cmdc.201700106⟩
Analogues of apelin-13 carrying diverse spacers and an ad hoc DY647-derived fluorophore were designed and synthesized by chemoselective acylation of α-hydrazinopeptides. The resulting probes retain very high affinity and efficacy for both the wild-t
Autor:
Iuliia A. Karpenko, Christel Valencia, Dominique Bonnet, Bernard Mouillac, Yves Mély, Marcel Hibert, Rémy Kreder, Andrey S. Klymchenko, Christiane Mendre, Pascal Villa
Publikováno v:
ChemBioChem. 15:359-363
Classical fluorescence-based approaches to monitor ligand-protein interactions are generally hampered by the background signal of unbound ligand, which must be removed by tedious washing steps. To overcome this major limitation, we report here the fi
Autor:
Christel Valencia, Pascal Villa, Didier Rognan, Marcel Hibert, Nathanael Weill, Sophie Gioria
Publikováno v:
Molecular Informatics. 30:521-526
Oxytocin (OT) is a peptide hormone secreted by the pituitary gland that binds to a specific G protein-coupled receptor (OTR) to mediate both peripheral and central actions. It notably induces uterine contraction during labor and stimulates lactation
Autor:
Yves Mély, Mayeul Collot, Christel Valencia, Pascal Villa, Ludovic Richert, Andrey S. Klymchenko, Dominique Bonnet, Marcel Hibert, Iuliia A. Karpenko
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2015, 137, pp.405-412
Journal of the American Chemical Society, American Chemical Society, 2015, 137, pp.405-412
Polarity-sensitive fluorogenic dyes raised considerable attention because they can turn on their fluorescence after binding to biological targets, allowing background-free imaging. However, their brightness is limited, and they do not operate in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59f2a6432269b65a46869ded279eac0
https://hal.archives-ouvertes.fr/hal-01141604
https://hal.archives-ouvertes.fr/hal-01141604
Autor:
Christian Cambillau, Valérie Campanacci, Véronique Roig-Zamboni, Arnaud Gruez, Christel Valencia
Publikováno v:
Journal of Biological Chemistry. 278:34582-34586
Because of its toxicity, oxalate accumulation from amino acid catabolism leads to acute disorders in mammals. Gut microflora are therefore pivotal in maintaining a safe intestinal oxalate balance through oxalate degradation. Oxalate catabolism was fi
Autor:
Christel Valencia, Damien Maurin, Loréna Scappucini-Calvo, Valérie Campanacci, Renaud Vincentelli, Christophe Bignon, Yves Bourne, Christian Cambillau, Frédéric Frassinetti, Stéphane Canaan
Publikováno v:
Protein science : a publication of the Protein Society. 13(10)
One of the main stumbling blocks encountered when attempting to express foreign proteins in Escherichia coli is the occurrence of amorphous aggregates of misfolded proteins, called inclusion bodies (IB). Developing efficient protein native structure
Autor:
Sacha Grisel, Christel Valencia, Christian Cambillau, Valérie Campanacci, Véronique Roig-Zamboni, Aurelia Salomoni, Mariella Tegoni, Arnaud Gruez
Publikováno v:
Journal of molecular biology. 343(1)
In the context of a medium-scaled structural genomics program aiming at solving the structures of as many as possible bacterial unknown open reading frame products from Escherichia coli (Y prefix), we have solved the structure of YdcW at 2.1 A resolu
Autor:
Didier Nurizzo, Mariella Tegoni, Christian Cambillau, Valérie Campanacci, Silvia Spinelli, Christel Valencia
Publikováno v:
FEBS letters. 562(1-3)
Lipocalins form a large multifunctional family of small proteins (15–25 kDa) first discovered in eukaryotes. More recently, several types of bacterial lipocalins have been reported, among which Blc from Escherichia coli is an outer membrane lipopro