Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christel Ramirez"'
Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma
Autor:
Anthony Lozano, Francois-Régis Souche, Carine Chavey, Valérie Dardalhon, Christel Ramirez, Serena Vegna, Guillaume Desandre, Anaïs Riviere, Amal Zine El Aabidine, Philippe Fort, Leila Akkari, Urszula Hibner, Damien Grégoire
Publikováno v:
eLife, Vol 12 (2023)
Quantitative differences in signal transduction are to date an understudied feature of tumour heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human tumours, is a prototypic example of distinct cell fates being driven
Externí odkaz:
https://doaj.org/article/a6847e4afd534521b7463f84208c628a
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Tumor-associated macrophages (TAMs) are a major component of the tumor immune microenvironment (TIME) and are associated with a poor prognostic factor in several cancers. TAMs promote tumor growth by facilitating immunosuppression, angiogenesis, and
Externí odkaz:
https://doaj.org/article/b4e7477ff3b7496b8b0c2e3a21ae32a5
Autor:
Anthony Lozano, Francois-Régis Souche, Carine Chavey, Valérie Dardalhon, Christel Ramirez, Serena Vegna, Guillaume Desandre, Anaïs Riviere, Amal Zine El Aabidine, Philippe Fort, Leila Akkari, Urszula Hibner, Damien Grégoire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f697ab367654f5a3200c05ceb299dd9
https://doi.org/10.7554/elife.76294.sa2
https://doi.org/10.7554/elife.76294.sa2
Autor:
Yuchen Guo, Haiqiu Wu, Haojie Jin, Weiping Zhou, Dan Cui, Yangyang Zhou, Shengxian Yuan, Cor Lieftink, Roderick L. Beijersbergen, ReneÌ Bernards, Yaoping Shi, E. Marielle Hijmans, Astrid Bosma, Nikita Isima, Jing Ling, Marnix H. P. de Groot, Yuan Yang, Matheus H. Dias, Xingling Zheng, Bo Zhai, Yuanyuan Lv, Fleur Jochems, Hui Wang, Leila Akkari, Serena Vegna, Christel Ramirez, Wenxin Qin, Siying Wang, Chong Sun, Cun Wang, Liqin Wang
Publikováno v:
Nature. 595:730-734
Hepatocellular carcinoma (HCC)—the most common form of liver cancer—is an aggressive malignancy with few effective treatment options1. Lenvatinib is a small-molecule inhibitor of multiple receptor tyrosine kinases that is used for the treatment o
Autor:
Damien Grégoire, Urszula Hibner, Leila Akkari, Philippe Fort, Amal Zine El Aabidine, Valérie Dardalhon, Anaïs Riviere, Guillaume Desandré, Serena Vegna, Christel Ramirez, François-Régis Souche, Anthony Lozano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e51153f6698db341151792c07953d8cc
https://doi.org/10.15252/rc.2022340572
https://doi.org/10.15252/rc.2022340572
Autor:
Christel Ramirez, Sjoerd Klarenbeek, Niels de Wit, Daniel Taranto, Leila Akkari, Marnix H. P. de Groot, Martijn van Baalen, Serena Vegna
Publikováno v:
Current Protocols. 1
The rising incidence and increasing mortality of hepatocellular carcinoma (HCC), combined with its high tumor heterogeneity, lack of druggable targets, and tendency to develop resistance to chemotherapeutics, make the development of better models for
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
Tumor-associated macrophages (TAMs) are a major component of the tumor immune microenvironment (TIME) and are associated with a poor prognostic factor in several cancers. TAMs promote tumor growth by facilitating immunosuppression, angiogenesis, and
Autor:
Christel Ramirez, Aimee du Chatinier, Wei Wang, Zheng Xue, René Bernards, Fleur Jochems, Sara Mainardi, Liqin Wang, Antonio Mulero Sanchez, Hein te Riele, Ben Morris, Leila Akkari, Wenxin Qin, Cun Wang, Jules Gadiot, Serena Vegna, Dongmei Gao, Rodrigo Leite de Oliveira, Cor Lieftink, Roderick L. Beijersbergen, Bastiaan Evers, Bente Benedict, Arnout Schepers, Guangzhi Jin, Haojie Jin
Publikováno v:
Nature
Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical dependencies1,2; broad-spectrum kinase inhibitors such as sorafenib provide only a modest benefit to patients with hepatocellular carcinoma3. The induction of s