Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christel Menet"'
Autor:
Thomas Fontaine, Andreas Busch, Toon Laeremans, Stéphane De Cesco, Yi-Lynn Liang, Veli-Pekka Jaakola, Zara Sands, Sarah Triest, Simonas Masiulis, Lies Dekeyzer, Noor Samyn, Nicolas Loeys, Lisa Perneel, Melanie Debaere, Murielle Martini, Charlotte Vantieghem, Richa Virmani, Kamila Skieterska, Stephanie Staelens, Rosa Barroco, Maarten Van Roy, Christel Menet
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety. Brain-produced hormones such as α-
Externí odkaz:
https://doaj.org/article/f05dbb65117040f98bbf56edfbe2bf19
Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor
Autor:
Marie Pardon, Pieter Claes, Sarah Druwé, Murielle Martini, Aleksandra Siekierska, Christel Menet, Peter A. M. de Witte, Daniëlle Copmans
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
New pharmacological approaches that target orexin receptors (OXRs) are being developed to treat sleep disorders such as insomnia and narcolepsy, with fewer side effects than existing treatments. Orexins are neuropeptides that exert excitatory effects
Externí odkaz:
https://doaj.org/article/30dde744214246fa83c94fa1c4cdc927
Autor:
Toon Laeremans, Zara A. Sands, Pieter Claes, Ann De Blieck, Stephane De Cesco, Sarah Triest, Andreas Busch, David Felix, Abhinav Kumar, Veli-Pekka Jaakola, Christel Menet
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The human genome encodes 850 G protein-coupled receptors (GPCRs), half of which are considered potential drug targets. GPCRs transduce extracellular stimuli into a plethora of vital physiological processes. Consequently, GPCRs are an attractive drug
Externí odkaz:
https://doaj.org/article/ea4599d8f7de44b08618672b548d1833
Autor:
Stéphanie Lavazais, Manja Jargosch, Sonia Dupont, Frédéric Labéguère, Christel Menet, Catherine Jagerschmidt, Frenz Ohm, Laszlo Kupcsik, Isabelle Parent, Céline Cottereaux, Florence Marsais, Line Oste, An Van de Water, Thierry Christophe, Steve De Vos, Padraic Fallon, Felix Lauffer, Philippe Clément-Lacroix, Kilian Eyerich, Reginald Brys
Publikováno v:
Science Translational Medicine. 15
Innate immunity not only shapes the way epithelial barriers interpret environmental cues but also drives adaptive responses. Therefore, modulators of innate immune responses are expected to have high therapeutic potential across immune-mediated infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d1ddc3b64e21e46fda5864368a152e3
https://doi.org/10.1126/scitranslmed.abj3289
https://doi.org/10.1126/scitranslmed.abj3289
Publikováno v:
Current opinion in drug discoverydevelopment. 9(4)
This article reviews the literature from January 2004 to January 2006 relating to the use of parallel chemistry compound libraries in drug discovery. Examples of libraries that have yielded active compounds across a range of biological targets are pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::833c534fb809bd751937e8b7c7a42de6
https://pubmed.ncbi.nlm.nih.gov/16889227
https://pubmed.ncbi.nlm.nih.gov/16889227